6-Nitroindazole

Product Name: 6-Nitroindazole
CAS No.: 7597-18-4
Chemical Name: 6-Nitroindazole
Synonyms: 6-NITRO-1H-INDAZOLE;6-Nitrobrazol;6-NITROINDAZOLE;6-Nitroindazoles;6-Nitroisoindazole;6-nitro-1h-indazol;6-Nitroindazole>6-Nitroindazole 97%;6-Nitroindazole,98%;6-Nitroindazole ,97%
CBNumber: CB8358413
Molecular Formula: C7H5N3O2
Formula Weight: 163.13
MOL File: 7597-18-4.mol

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6-Nitroindazole Property

Melting point:: 180-182 °C (lit.)
Boiling point:: 290.19°C (rough estimate)
Density: 1.4141 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: very faint turbidity in hot Methanol
pka: 11.08±0.40(Predicted)
form: Powder
color: Light Yellow
BRN: 7812
CAS DataBase Reference: 7597-18-4(CAS DataBase Reference)
NIST Chemistry Reference: 6-Nitroindazole(7597-18-4)
EPA Substance Registry System: 1H-Indazole, 6-nitro- (7597-18-4)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38-40-68-36
Safety Statements: 26-27-36/37/39
WGK Germany: 3
RTECS: NK7962100
TSCA: Yes
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N17513
Product name: 6-Nitroindazole
Purity: 97%
Packaging: 100g
Price: $254
Updated: 2023/06/20

TCI Chemical

Product number: N0399
Product name: 6-Nitroindazole
Purity: >98.0%(GC)
Packaging: 25g
Price: $34
Updated: 2024/03/01

TCI Chemical

Product number: N0399
Product name: 6-Nitroindazole
Purity: >98.0%(GC)
Packaging: 250g
Price: $167
Updated: 2024/03/01

Alfa Aesar

Product number: A16213
Product name: 6-Nitro-1H-indazole, 97%
Packaging: 100g
Price: $88
Updated: 2021/12/16

Alfa Aesar

Product number: A16213
Product name: 6-Nitro-1H-indazole, 97%
Packaging: 25g
Price: $35.8
Updated: 2021/12/16

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6-Nitroindazole Chemical Properties,Usage,Production

Description

6-Nitroindazole is a competitive and reversible Monoamine oxidase(MAO)inhibitor. It can inhibit MAO-A and MAO-B (IC50= 2.5 μM). Monoamine oxidase (MAO) B is a mitochondrial enzyme selectively involved in the oxidative activation of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to toxic pyridinium cations producing Parkinsonism in animal models. In addition, it is an nNOS inhibitor, which has neuroprotective effects^[1].

Chemical Properties

yellow powder

Uses

Anticonvulsant.

Synthesis

6-Nitroindazole is prepared by (2-methyl-5-nitrophenyl)azo phenyl sulfide and 1,8-diazabicyclo[5.4.0]undec-7-ene in the presence of concentrated acetonitrile.

References

[1] HERRAIZTOMAS GuillénHugo AránVicente J. Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).[J]. Free Radical Research, 2009: 975-984. DOI:10.1080/10715760903159170.

6-Nitroindazole Preparation Products And Raw materials

Raw materials

Sodium nitrite 2-Methyl-5-nitroaniline Acetic acid

Preparation Products

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6-Nitroindazole Suppliers

Americas 1 Belgium 3 Canada 1 China 230 Europe 4 Germany 6 India 17 Japan 4 Russia 1 Switzerland 4 The Netherlands 1 Ukraine 1 United Kingdom 11 United States 37 Global 321

GLR Innovations

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CHEMSWORTH

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View Lastest Price from 6-Nitroindazole manufacturers

Nanjing Fred Technology Co., Ltd

Product: 6-Nitroindazole 7597-18-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-27

Shaanxi Dideu Medichem Co. Ltd

Product: 6-Nitroindazole 7597-18-4
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-31

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: 6-Nitro-1H-indazole 7597-18-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ≥98% by HPLC
Supply Ability: 100kg/month
Release date: 2023-01-05

7597-18-4, 6-NitroindazoleRelated Search:

3-Methyl-6-nitroindazole 3-Nitroacetophenone Sodium 3-nitrobenzenesulphonate 2-Ethyl-5-nitrobenzenamine ,98% 5-Amino-2-methylbenzenesulfonamide N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine Pazopanib Impurity 48 3-methyl-1H-indazol-6-amine 5-Amino-2,3-dimethyl-2H-indazole Pazopanib Impurity 32 2,4-Dichloropyrimidine Benzenamine, 2-ethyl-4-nitro- 3-AMINO-4-METHYLBENZENESULFONAMIDE 2-amino-5-methylbenzenesulfonamide Pazopanib-d6 2H-Indazol-4-amine, 2,3-dimethyl- 1H-Indazol-6-amine, N-(2-chloro-4-pyrimidinyl)-3-methyl- Pazopanib Impurity 47

1H-Indazole, 6-nitro-

6-nitro-1h-indazol

6-Nitroisoindazole

6-NITRO-1H-INDAZOLE

6-NITROINDAZOLE

6-Nitro-1(2)H-indazole

6-Nitroindazole ,97%

6-Nitroindazole,98%

6-Nitroindazoles

6-Nitro-1H-indazole,97%

6-Nitroindazole 97%

6-Nitroindazole&gt

6-Nitrobrazol

Pazopanib Impurity 59

Axitinib Impurity N22

7597-18-4

9597-18-4

Building Blocks

Heterocyclic Building Blocks

Indazoles

Inhibitors

Nitric Oxide Reagents

Building Blocks

Heterocyclic Building Blocks

Heterocyclic Compounds

All Inhibitors

Indazoles

Intermediate