Triethylene glycol monobenzyl ether
- Product Name
- Triethylene glycol monobenzyl ether
- CAS No.
- 55489-58-2
- Chemical Name
- Triethylene glycol monobenzyl ether
- Synonyms
- BnO-PEG3-OH;CAS_55489-58-2;Benzyl-PEG3-OH;HO-(CH2CH2O)3-Bn;TEGmonobenzylether;RARECHEM AH CK 0201;TRIETHYLENEGLYKOLMONOBENZYLETHER;Triethyleneglykolmonobenzyl ethe;TRIETHYLENEGLYCOLMONOBENZYL ETHER;Triehylene glycol monobenzyl ether
- CBNumber
- CB8371935
- Molecular Formula
- C13H20O4
- Formula Weight
- 240.3
- MOL File
- 55489-58-2.mol
Triethylene glycol monobenzyl ether Property
- Boiling point:
- 131 °C
- Density
- 1.09
- refractive index
- 1.5050 to 1.5080
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- 14.36±0.10(Predicted)
- color
- Colorless to Light yellow to Light orange
- InChI
- InChI=1S/C13H20O4/c14-6-7-15-8-9-16-10-11-17-12-13-4-2-1-3-5-13/h1-5,14H,6-12H2
- InChIKey
- KVPHZILZNXDCNH-UHFFFAOYSA-N
- SMILES
- C(O)COCCOCCOCC1=CC=CC=C1
- CAS DataBase Reference
- 55489-58-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2909199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T1996
- Product name
- Triethylene Glycol Monobenzyl Ether
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $169
- Updated
- 2025/07/31
- Product number
- T1996
- Product name
- Triethylene Glycol Monobenzyl Ether
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $672
- Updated
- 2025/07/31
- Product number
- T776515
- Product name
- Triethylene Glycol Monobenzyl Ether
- Packaging
- 10g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- BP-24386
- Product name
- Benzyl-PEG4-alcohol
- Purity
- 98%
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 2708-1-09
- Product name
- 2-{2-[2-(Benzyloxy)ethoxy]ethoxy}ethan-1-ol
- Purity
- 98.0%
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
Triethylene glycol monobenzyl ether Chemical Properties,Usage,Production
Description
Benzyl-PEG4-alcohol is a PEG linker with an acid labile, benzyl protecting group and a reactive primary alcohol. The primary alcohol can react and further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Uses
Triethylene Glycol Monobenzyl Ether is used in the preparation of self-assembled monolayers with multiple binding sites and biocompatible imprinted cavities for biosensor application. Also used in the synthesis of novel ethoxylated inositol surfactants.
Synthesis
100-44-7
112-27-6
55489-58-2
Triethylene glycol (30 g, 0.2 mol) was dissolved in aqueous sodium hydroxide solution (8 g NaOH dissolved in 8 mL H2O) and stirred for 10 minutes. Subsequently, benzyl chloride (7 mL, 0.062 mol) was slowly added to the reaction system, and the reaction mixture was heated to 100 °C and stirred continuously overnight. Upon completion of the reaction, the crude product was diluted with saturated sodium chloride solution (500 mL) and subsequently extracted with dichloromethane (2 x 400 mL). The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. Purification by column chromatography (silica gel as stationary phase, eluent ethyl acetate to ethyl acetate/methanol, 10:1, v/v/v) afforded the light yellow oily target product triglyceride monobenzyl ether (9.87 g, 67% yield).
IC 50
PEGs
References
[1] European Journal of Organic Chemistry, 2008, # 17, p. 2900 - 2914
[2] Journal of the American Chemical Society, 2013, vol. 135, # 25, p. 9248 - 9251
[3] Synthetic Communications, 1986, vol. 16, # 1, p. 19 - 26
[4] Tetrahedron Letters, 2001, vol. 42, # 23, p. 3819 - 3822
[5] Patent: US2008/207505, 2008, A1. Location in patent: Page/Page column 31
Triethylene glycol monobenzyl ether Preparation Products And Raw materials
Raw materials
Preparation Products
Triethylene glycol monobenzyl ether Suppliers
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- Country
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View Lastest Price from Triethylene glycol monobenzyl ether manufacturers
- Product
- BnO-PEG3-OH 55489-58-2
- Price
- US $3192.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 300kg
- Release date
- 2025-11-15
- Product
- 2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethanol 55489-58-2
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2025-09-24
- Product
- Triethylene glycol monobenzyl ether 55489-58-2
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-30