ChemicalBook > CAS DataBase List > 4-Hydroxy-D-(-)-2-phenylglycine

4-Hydroxy-D-(-)-2-phenylglycine

Product Name
4-Hydroxy-D-(-)-2-phenylglycine
CAS No.
22818-40-2
Chemical Name
4-Hydroxy-D-(-)-2-phenylglycine
Synonyms
(R)-2-AMino-2-(4-hydroxyphenyl)acetic acid;H-D-PHG(4-OH)-OH;D-4-HYDROXYPHENYLGLYCINE;4-HYDROXY-D-PHENYLGLYCINE;(R)-(-)-2-Phenylglycine amide;AMoxicillin Related CoMpound I;(2R)-2-amino-2-(4-hydroxyphenyl)acetic acid;B8372699;H-D-HPG-OH;D-4-OH-Phg-OH
CBNumber
CB8372699
Molecular Formula
C8H9NO3
Formula Weight
167.16
MOL File
22818-40-2.mol
More
Less

4-Hydroxy-D-(-)-2-phenylglycine Property

Melting point:
240 °C (dec.)(lit.)
alpha 
-156 º (c=1, 1 N HCl)
Boiling point:
295.73°C (rough estimate)
Density 
1.396
vapor pressure 
0Pa at 25℃
refractive index 
-158 ° (C=1, 1mol/L HCl)
storage temp. 
2-8°C
solubility 
5g/l
form 
Liquid
pka
2.15±0.10(Predicted)
color 
Clear colorless to yellow
optical activity
[α]23/D 158±3°, c = 1 in 1 M HCl
Water Solubility 
5 g/L (20 ºC)
BRN 
2210998
LogP
-2.25
CAS DataBase Reference
22818-40-2(CAS DataBase Reference)
EPA Substance Registry System
Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (22818-40-2)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
TSCA 
Yes
HS Code 
29225000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2196
Product name
Amoxicillin Related Compound I
Packaging
50MG
Price
$485
Updated
2024/03/01
Sigma-Aldrich
Product number
215333
Product name
4-Hydroxy-D-phenylglycine
Purity
≥98%
Packaging
25g
Price
$50.1
Updated
2023/06/20
Sigma-Aldrich
Product number
1031591
Product name
Amoxicillin Related Compound I
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1310
Updated
2022/05/15
TCI Chemical
Product number
H0758
Product name
4-Hydroxy-D-(-)-2-phenylglycine
Purity
>99.0%(HPLC)(T)
Packaging
25g
Price
$40
Updated
2024/03/01
TCI Chemical
Product number
H0758
Product name
4-Hydroxy-D-(-)-2-phenylglycine
Purity
>99.0%(HPLC)(T)
Packaging
100g
Price
$77
Updated
2024/03/01
More
Less

4-Hydroxy-D-(-)-2-phenylglycine Chemical Properties,Usage,Production

Description

d-(p-Hydroxyphenyl)glycine (d-HPG) is widely used in large amounts as an important intermediate for the synthesis of amoxicillin and several other semisynthetic β-lactam antibiotics.

Chemical Properties

off-white powder

Uses

4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.

Uses

4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.

Definition

ChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise it from water and dry it in vacuo. [Beilstein 14 I 659.]

4-Hydroxy-D-(-)-2-phenylglycine Preparation Products And Raw materials

Raw materials

DL-P-Hydroxyphenylglycine Glyoxal Phenol DL-Tartaric acid D(-)-Tartaric acid p-Anisaldehyde Glyoxylic acid

Preparation Products

D-(-)-A-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM (2R)-2-[(4-Ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-(4-hydroxyphenyl)acetic acid
More
Less

4-Hydroxy-D-(-)-2-phenylglycine Suppliers

Americas 1 Belgium 2 Canada 4 China 370 Europe 3 France 1 Germany 9 India 32 Japan 6 Slovakia 1 South Korea 1 Spain 2 Switzerland 5 The Netherlands 1 Ukraine 1 United Kingdom 23 United States 54 Global 516
Chemtour Biotech Co., Ltd
Tel
+8617327281506
Email
market@chemtour.com
Country
China
ProdList
1472
Advantage
58
Shanghai Chang-Gen Chemical Technology Co., Ltd.
Tel
021-69106814 13917161715
Email
3007500651@qq.com
Country
China
ProdList
79
Advantage
60
Hubei Enxing Biotechnology Co., Ltd
Tel
16621771607
Email
exbio_tech@163.com
Country
China
ProdList
8359
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2210
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1998
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Yangzhou Aoxin Chemical Co., Ltd
Tel
0514-87754778 13901446058
Fax
+86-514-87752291
Email
sales@aochem.com
Country
China
ProdList
73
Advantage
66
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12458
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9551
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11660
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3296
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
13355009207 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18739
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4550
Advantage
62
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 15343847665
Fax
QQ：3470079902
Email
huawenchem@163.com
Country
China
ProdList
3206
Advantage
55
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2893
Advantage
58
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
4974
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Wuhan TCASChem Technology Co., Ltd.
Tel
027-86697669 13986148687
Fax
86-027-86697669
Email
sales@tcaschem.com
Country
China
ProdList
4089
Advantage
55
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9442
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4576
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9906
Advantage
55
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3933
Advantage
58
Shanghai Hongbang Pharmaceutical Co., Ltd.
Tel
021-64975436 18917636693
Fax
021-24280809
Email
1377976036@qq.com
Country
China
ProdList
297
Advantage
55
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1958
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9908
Advantage
55
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3123
Advantage
55
More
Less

View Lastest Price from 4-Hydroxy-D-(-)-2-phenylglycine manufacturers

Hebei Dangtong Import and export Co LTD
Product
4-Hydroxy-D-(-)-2-phenylglycine 22818-40-2
Price
US $72.00-60.00/kilograms
Min. Order
10kilograms
Purity
99%
Supply Ability
100tons
Release date
2023-02-22
Apeloa production Co.,Limited
Product
D(-)-4-Hydroxyphenylglycine 22818-40-2
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
1000
Release date
2024-04-30
Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
4-Hydroxy-D-(-)-2-phenylglycine 22818-40-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
10000ton
Release date
2024-04-24

22818-40-2, 4-Hydroxy-D-(-)-2-phenylglycineRelated Search:

4-Hydroxybenzoic acid 4-Aminophenylacetic acid 6-Aminocaproic acid D-2-Phenylglycine Glycine CHLOROPHOSPHONAZO III Methylparaben Betaine 4-Hydroxyphenylacetic acid Anilinoacetic acid α-Lipoic Acid D-(-)-A-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM,D-(-)-ALPHA-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM L-Phenylglycine 4-Hydroxybenzaldehyde D-4-Hydroxyphenylglycine methyl ester D(+)-Trehalose dihydrate D(+)-Malic acid (S)-Amlodipine

  • 4-HYDROXY-D-PHENYLGLYCINE
  • (R)-(-)-AMINO(4-HYDROXYPHENYL)ACETIC ACID
  • (R)-AMINO-(4-HYDROXY-PHENYL)-ACETIC ACID
  • (r)-alpha-amino-4-hydroxybenzeneacetic acid
  • (R)-ALPHA-AMINO-4-HYDROXYPHENYLACETIC ACID
  • (R)-4-HYDROXYPHENYLGLYCINE
  • (R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE
  • D-(-)-2-(4-HYDROXYPHENYL)GLYCINE
  • D(-)-2-(P-HYDROXYPHENYL)GLYCINE
  • D-(-)-A-4-HYDROXYPHENYLGLYCINE
  • D-4-HYDROXYPHENYLGLICYNE
  • D-(-)-4-HYDROXYPHENYLGLYCINE
  • D-4-HYDROXYPHENYLGLYCINE
  • D-ALPHA-PARA-HYDROXYPHENYLGLYCINE
  • (D)-(-)-ALFA-4-HYDROXYPHENYL GLYCINE
  • D-(-)-P-HYDROXYPHENYLGLYCINE
  • D-P-HYDROXYPHENYLGLYCINE
  • D(-)PARA-HYDROXY-PHENYLGLYCINE
  • HYDROXY PHENYL GLYCINE
  • H-D-HPG-OH
  • H-D-PHG(4-OH)-OH
  • H-D-PHG(4-HYDROXY)-OH
  • Cefoperazone Impurity 3
  • Amoxicillin Impurity 8（EP Impurity I）
  • Cefprozil Impurity 1（Cefprozil EP Impurity A）
  • Cefadroxil Impurity 7（Cefadroxil EP Impurity A）
  • D-(-)Pare Hydroxyphenylglycine
  • (theta)-benzeneaceticaci
  • .alpha.-amino-4-hydroxy-,(R)-Benzeneaceticacid
  • a-Amino-p-hydroxyphenylaceticacid
  • Benzeneaceticacid,alpha.-amino-4-hydroxy-,(R)-
  • Benzeneaceticacid,-amino-4-hydroxy-,(R)-
  • L-(-)-4-Hydroxy-α-aminophenylacetic acid
  • D(-)-P-Hydroxyphenylglycine, 98+%
  • (2R)-2-(4-Hydroxyphenyl)glycine
  • (R)-2-(p-Hydroxyphenyl)glycine
  • p-Hydroxy-D-phenylglycine
  • α-(4-Hydroxyphenyl)-D-glycine
  • (2R)-2-Amino-2-(4-hydroxyphenyl)ethanoic acid, (R)-Amino(4-hydroxyphenyl)acetic acid
  • Amoxicillin Related Compound I (15 mg) ((R)-2-Amino-2-(4-hydroxyphenyl)acetic acid)
  • D(-)-4-Hydroxyphenylglycine, 98+% 100GR
  • D(-)-4-Hydroxyphenylglycine, 98+% 25GR
  • D(-)-4-Hydroxyphenylglycine ,99%
  • D(-)-alpha-para-Hydroxyphenylglycine base
  • (R)-(-)-2-Amino-2-(4-hydroxyphenyl)acetic Acid 4-Hydroxy-D-phenylglycine
  • Benzeneacetic acid, a-aMino-4-hydroxy-, (aR)-
  • 4-Hydroxy-D-(-)-2-phenylglycine
  • (R)-2-AMino-2-(4-hydroxyphenyl)acetic acid
  • AMoxicillin EP IMpurity I
  • (-)-4-Hydroxy-D-phenylglycine, 98+%
  • D-(-)p-hydroxyphenylgcine Dane salt
  • AMoxicillin Related CoMpound I
  • 4-Hydroxy-D-(-)-2-phenylglycine, 99.0%(LC&T
  • D(-)-4-Hydroxyphenylglycine 4-Hydroxy-D-phenylglycine
  • Cefprozil impurity A
  • Cefadroxyl impurity A
  • Cefprozil Monohydrate EP Impurity A
  • (2R)-2-ammonio-2-(4-hydroxyphenyl)acetate