ChemicalBook > CAS DataBase List > 4-METHYLINDOLE-3-CARBOXALDEHYDE
4-METHYLINDOLE-3-CARBOXALDEHYDE
- Product Name
- 4-METHYLINDOLE-3-CARBOXALDEHYDE
- CAS No.
- 4771-48-6
- Chemical Name
- 4-METHYLINDOLE-3-CARBOXALDEHYDE
- Synonyms
- 4-METHYLINDOLE-3-ALDEHYDE;4-Methyl-3-carboxaldehyde;4-METHYLINDOLE-3-CARBALDEHYDE;4-Methylindole-3-caboxaldehyde;4-METHYLINDOLE-3-CARBOXALDEHYDE;4-Methyl-3-indolecarboxaldehyde;4-METHYL-1H-INDOLE-3-CARBALDEHYDE;4-Methyl-1H-indole-3-carboxaldehyde;1H-Indole-3-carboxaldehyde, 4-Methyl-;1H-Indole-3-carboxaldehyde, 4-methyl- (9CI)
- CBNumber
- CB8375524
- Molecular Formula
- C10H9NO
- Formula Weight
- 159.18
- MOL File
- 4771-48-6.mol
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4-METHYLINDOLE-3-CARBOXALDEHYDE Property
- Melting point:
- 192-194℃
- Boiling point:
- 347.0±22.0 °C(Predicted)
- Density
- 1.226
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 15.86±0.30(Predicted)
- Appearance
- Yellow to brown Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SYX00293
- Product name
- 3-Formyl-4-methylindole
- Packaging
- 1g
- Price
- $107
- Updated
- 2025/07/31
TRC
- Product number
- F701230
- Product name
- 3-Formyl-4-methylindole
- Packaging
- 500mg
- Price
- $145
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 036846
- Product name
- 4-Methyl-1H-indole-3-carbaldehyde
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR960850
- Product name
- 3-Formyl-4-methylindole
- Purity
- 95%
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 036846
- Product name
- 4-Methyl-1H-indole-3-carbaldehyde
- Packaging
- 500mg
- Price
- $126
- Updated
- 2021/12/16
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4-METHYLINDOLE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production
Synthesis
16096-32-5
68-12-2
4771-48-6
GENERAL STEPS: The Vilsmeier-Haack reagent was prepared by slowly adding POCl3 (60 mmol, 6 mL) dropwise to dry DMF (30 mL) pre-cooled to 0 °C under stirring conditions. Subsequently, the reaction mixture was continued to be stirred at 0 °C for 10-15 min. 4-Methylindole (10 mmol) was dissolved in DMF (5 mL) and the resulting solution was added within the Vilsmeier-Haack reagent prepared above. The reaction mixture was warmed to 35 °C with continuous stirring for 1 hour. After completion of the reaction, it was cooled to room temperature and ice water (6 mL) and 30% NaOH aqueous solution (13 mL) were added sequentially, followed by heating the mixture to reflux for 20 min and then cooled to room temperature. The reaction mixture was extracted with dichloromethane (20 mL x 3), the organic phases were combined and dried with anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by fast column chromatography using 15-25% acetone/petroleum ether (boiling range 60-90 °C) as eluent to afford the target product 4-methylindole-3-carbaldehyde.
References
[1] Chemical Biology and Drug Design, 2011, vol. 78, # 5, p. 864 - 868
[2] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 776 - 783
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 7, p. 1301 - 1305
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 6, p. 1793 - 1798
[5] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 7, p. 3780 - 3790
4-METHYLINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
N,N-Dimethylformamide
Nickel
Phosphorus oxitrichloride
N,N-Dimethyformamide diethy acetal
3-Nitro-o-xylene
Preparation Products
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View Lastest Price from 4-METHYLINDOLE-3-CARBOXALDEHYDE manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- 4-Methylindole-3-caboxaldehyde 4771-48-6
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
Shaanxi Dideu Medichem Co. Ltd
- Product
- 4-methyl-1H-indole-3-carbaldehyde 4771-48-6
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-07-17
Career Henan Chemical Co
- Product
- 4-METHYLINDOLE-3-CARBOXALDEHYDE 4771-48-6
- Price
- US $1.00/g
- Min. Order
- 100EA
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20
4771-48-6, 4-METHYLINDOLE-3-CARBOXALDEHYDERelated Search:
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