2-Amino-5-bromine-2'-chloro benzophenone

Product Name: 2-Amino-5-bromine-2'-chloro benzophenone
CAS No.: 60773-49-1
Chemical Name: 2-Amino-5-bromine-2'-chloro benzophenone
Synonyms: IFLAB-BB F1386-0356;2-Amino-5-Bromine-2-Chloro;5-Bromo-2'-chloro-2-aminobenzophenone;2-Amino-5-bromo-2'-Chlorobenzophenone;2-Amino-5-bromo-2'-Chlorobenzophenone;2-Amino-5-bromine-2'-chlorobenzophenone;2-AMINO-5-BROMINE-2'-CHLORO BENZOPHENONE;Methanone,(2-aMino-5-broMophenyl)(2-chlorophenyl)-;(2-AMINO-5-BROMO-PHENYL)-(2-CHLORO-PHENYL)-METHANONE;(E)-1,5-diphenyl-3-(2-phenylethynyl)-3-pent-1-en-4-ynol
CBNumber: CB8379335
Molecular Formula: C13H9BrClNO
Formula Weight: 310.57
MOL File: 60773-49-1.mol

More

Less

2-Amino-5-bromine-2'-chloro benzophenone Property

Melting point:: 85-87°C
Boiling point:: 456.2±40.0 °C(Predicted)
Density: 1.568±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: -1.03±0.10(Predicted)
color: Yellow
InChI: InChI=1S/C13H9BrClNO/c14-8-5-6-12(16)10(7-8)13(17)9-3-1-2-4-11(9)15/h1-7H,16H2
InChIKey: GTLLBGFJGUJABH-UHFFFAOYSA-N
SMILES: C(C1=CC(Br)=CC=C1N)(C1=CC=CC=C1Cl)=O
CAS DataBase Reference: 60773-49-1(CAS DataBase Reference)

More

Less

Safety

HS Code: 29223990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: A601600
Product name: 2-Amino-5-bromo-2''-chlorobenzophenone
Packaging: 5g
Price: $135
Updated: 2021/12/16

TRC

Product number: A601600
Product name: 2-Amino-5-bromo-2''-chlorobenzophenone
Packaging: 10g
Price: $150
Updated: 2021/12/16

Usbiological

Product number: 001970
Product name: 2-Amino-5-bromo-2'-chlorobenzophenone
Packaging: 1g
Price: $403
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 19531
Product name: 2-Amino-5-bromo-2?-chlorobenzophenone
Packaging: 1g
Price: $560
Updated: 2021/12/16

Matrix Scientific

Product number: 092381
Product name: 2-Amino-5-bromo-2'-chlorobenzophenone
Purity: 95+%
Packaging: 1g
Price: $284
Updated: 2021/12/16

More

Less

2-Amino-5-bromine-2'-chloro benzophenone Chemical Properties,Usage,Production

Chemical Properties

yellow crystal powder

Uses

Phenazepam metabolite.

Synthesis

609-65-4

106-40-1

60773-49-1

General procedure for the synthesis of 2-amino-5-bromo-2'-chlorobenzophenone from o-chlorobenzoyl chloride and 4-bromoaniline: 1. o-Chlorobenzoyl chloride (177 mL, 1.4 mol) was cooled to 0°C in an ice-water bath in a 2L flask equipped with a condenser and thermometer. 2. 4-Bromoaniline (100 g, 0.58 mol) was added to the cooled solution. 3. The mixture was heated to 120 °C and held at this temperature for 1 hour until complete consumption of 4-bromoaniline was confirmed by TLC analysis (Expanding Agent: EtOAc:Hexane = 1:4). 4. The solution was heated to 160 °C and anhydrous ZnCl2 (95 g, 0.70 mol, pre-flame-dried) was added all at once. 5. Increase the temperature to 195 °C and stir at this temperature for 3 hours until no more bubbles are produced. 6. cooled the mixture to 120 °C and slowly added 12% HCl aqueous solution (350 mL) dropwise. 7. After maintaining reflux for 20 minutes, pour off the aqueous layer. Repeat this process 4 times. 8. Add water (350mL), keep refluxing for 20 minutes and pour out the water. Repeat until solids are no longer lumpy. 9. Add 72% H2SO4 (700mL) to the residue and heat and reflux for approximately 1 hour until the reaction mixture becomes a homogeneous dark colored solution. 10. The hot acidic solution was poured into the ice-water mixture with stirring, and the resulting precipitate was filtered and washed with plenty of cold water until the pH of the solid was about 6. 11. the solid was suspended in ice water, 40% aqueous NaOH solution (290 mL) was carefully added, stirred for 2 hours and the solid was filtered and washed with ice water. 12. Suspend the solid again in ice water, adjust dropwise with 40% H2SO4 to pH ≈ 3, filter the remaining solid and wash with water to neutral. 13. The yellow solid product (66.1 g, 37.0% yield) was dried and used in the next step without further purification. Product characterization: 1H NMR (300MHz, CDCl3) δ 6.49 (s, br, 2H), 6.65 (d, 1H, J=8.82Hz), 7.26-7.8 (m, 6H).

References

[1] Patent: WO2003/82832, 2003, A2. Location in patent: Page/Page column 49; 50-51
[2] Pharmaceutical Chemistry Journal, 1977, vol. 11, # 11, p. 1520 - 1525
[3] Khimiko-Farmatsevticheskii Zhurnal, 1977, vol. 11, # 11, p. 85 - 91

2-Amino-5-bromine-2'-chloro benzophenone Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-Amino-5-bromine-2'-chloro benzophenone Suppliers

Canada 2 China 104 Europe 2 Germany 1 India 2 Slovakia 1 United Kingdom 9 United States 22 Global 143

Jiangsu Jingye Pharmaceutical

Tel: 0519-82765788 18001496617
Email: 2807841045@qq.com
Country: China
ProdList: 108
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768836
Email: 1791901229@qq.com
Country: China
ProdList: 6950
Advantage: 52

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

More

Less

View Lastest Price from 2-Amino-5-bromine-2'-chloro benzophenone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Amino-5-bromo-2’-chlorobenzophenone 60773-49-1
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 50kg/month
Release date: 2021-06-03

Wuhan Boyuan Import & Export Co., LTD

Product: 2-Amino-5-bromine-2'-chloro benzophenone 60773-49-1
Price: US $12.00/mg
Min. Order: 1mg
Purity: 99.96%
Supply Ability: 500ton
Release date: 2023-06-27

Career Henan Chemical Co

Product: 2-Amino-5-bromine-2'-chloro benzophenone 60773-49-1
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 85.0-99.8%
Supply Ability: 20tons
Release date: 2020-01-08

60773-49-1, 2-Amino-5-bromine-2'-chloro benzophenoneRelated Search:

2-Aminobenzophenone ALTRENOGEST 4-Chlorobenzophenone Glycine 3-Aminophenol Benzophenone 6-Aminocaproic acid 2-Amino-5-chlorobenzophenone Tris(hydroxymethyl)aminomethane 3'-Bromoacetophenone 4-BROMO-2-METHYLANILINE HYDROCHLORIDE 2-AMINO-5-BROMOBENZOPHENONE 1-(2-amino-5-bromophenyl)ethanone 4-BROMO-2-ETHYLANILINE HYDROCHLORIDE Esculetin N-[4-Bromo-2-(2-chlorobenzoyl)phenyl]-2-chloroacetamide Bromine 2-Aminobenzylchloride

2-AMINO-5-BROMINE-2'-CHLORO BENZOPHENONE

(2-AMINO-5-BROMO-PHENYL)-(2-CHLORO-PHENYL)-METHANONE

5-Bromo-2'-chloro-2-aminobenzophenone

2-Amino-5-Bromine-2-Chloro

IFLAB-BB F1386-0356

(E)-1,5-diphenyl-3-(2-phenylethynyl)-3-pent-1-en-4-ynol

Methanone,(2-aMino-5-broMophenyl)(2-chlorophenyl)-

2-Amino-5-bromine-2'-chlorobenzophenone

2-Amino-5-bromo-2'-Chlorobenzophenone

60773-49-1

C13H9NOBrCl

C13H9BrClNO

Aromatic Benzophenones & Derivatives (substituted)

Amines

Aromatics

Metabolites & Impurities