ChemicalBook > CAS DataBase List > 4-(Chloromethyl)pyridine hydrochloride

4-(Chloromethyl)pyridine hydrochloride

Product Name
4-(Chloromethyl)pyridine hydrochloride
CAS No.
1822-51-1
Chemical Name
4-(Chloromethyl)pyridine hydrochloride
Synonyms
4-PICOLYL CHLORIDE HYDROCHLORIDE;4-Picolyl chloride;TIMTEC-BB SBB003917;4-Picolyl chloride h;4-(Chloromethyl)pyridine HCL;4-Plcolyl Chloride Hydrochloride;4-(Chloromethyl) Pyridine HCL 99%;4-(Chloromethyl)pyridine hydrochl;4-(CHLOROMETHYL)PYRIDINIUM CHLORIDE;4-Picolyl chloride hydrochloride,97%
CBNumber
CB8380214
Molecular Formula
C6H6ClN.ClH
Formula Weight
164.03
MOL File
1822-51-1.mol
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4-(Chloromethyl)pyridine hydrochloride Property

Melting point:
166-173 °C(lit.)
storage temp. 
Inert atmosphere,2-8°C
solubility 
soluble in DMSO, Methanol
form 
Fine Crystalline Powder
color 
Yellow to orange
Water Solubility 
750 g/L (20 ºC)
Sensitive 
Hygroscopic
BRN 
3689154
CAS DataBase Reference
1822-51-1(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-4-22-36/37/38
Safety Statements 
26-36/37/39-45-36
RIDADR 
UN 3261 8/PG 3
WGK Germany 
3
F 
3-10
Hazard Note 
Corrosive
HazardClass 
8
PackingGroup 
III
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P43807
Product name
4-(Chloromethyl)pyridine hydrochloride
Purity
97%
Packaging
10g
Price
$24.8
Updated
2024/03/01
Sigma-Aldrich
Product number
P43807
Product name
4-(Chloromethyl)pyridine hydrochloride
Purity
97%
Packaging
100g
Price
$160
Updated
2024/03/01
TCI Chemical
Product number
C0805
Product name
4-(Chloromethyl)pyridine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$113
Updated
2024/03/01
TCI Chemical
Product number
C0805
Product name
4-(Chloromethyl)pyridine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
250g
Price
$675
Updated
2024/03/01
Alfa Aesar
Product number
A12859
Product name
4-(Chloromethyl)pyridine hydrochloride, 98%
Packaging
5g
Price
$31.65
Updated
2024/03/01
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4-(Chloromethyl)pyridine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

YELLOW TO ORANGE FINE CRYSTALLINE POWDER

Uses

It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar 'handle' which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst?15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Purification Methods

Purify it by recrystallisation from EtOH or EtOH/dry Et2O. It melts between 171o and 175o, and the clear melt resolidifies on further heating at 190o and turns red to black at 280o but does not melt again. The picrate-hydrochloride (prepared in EtOH) has m 146-147o. The free base is an oil. [Mosher & Tessieri J Am Chem Soc 73 4925 1951, Beilstein 20 III/IV 2752.]

4-(Chloromethyl)pyridine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

3-(AMINOMETHYL)PYRIDINE N-Methyl-1-(pyridin-4-yl)methanamine
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4-(Chloromethyl)pyridine hydrochloride Suppliers

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View Lastest Price from 4-(Chloromethyl)pyridine hydrochloride manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
4-(Chloromethyl)pyridine hydrochloride 1822-51-1
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05
Hebei Yanxi Chemical Co., Ltd.
Product
4-(Chloromethyl)pyridine hydrochloride 1822-51-1
Price
US $15.00-6.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-24
Hebei Mojin Biotechnology Co., Ltd
Product
4-(Chloromethyl)pyridine hydrochloride 1822-51-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-11

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