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BLASTICIDIN S HYDROCHLORIDE

Product Name
BLASTICIDIN S HYDROCHLORIDE
CAS No.
3513-03-9
Chemical Name
BLASTICIDIN S HYDROCHLORIDE
Synonyms
BLASTICIDIN S HCL;Blasticidine S HCl;BLASTICIDIN S 50MG;Miewen S hydrochloride;Blasticidin S (10 mg/ml);BLASTICIDIN S HYDROCHLORIDE;BLASTICIDINE S HYDROCHLORIDE;Blasticidin S (10 mg/mL in Solution);Blasticidine S hydrochloride solution;BLASTICIDIN S HYDROCHLORIDE USP/EP/BP
CBNumber
CB8383972
Molecular Formula
C17H27ClN8O5
Formula Weight
458.9
MOL File
3513-03-9.mol
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BLASTICIDIN S HYDROCHLORIDE Property

Melting point:
224-225 °C (decomp)
storage temp. 
−20°C
solubility 
Soluble in Water (greater than 25 mg/ml)
form 
Liquid
color 
White
Water Solubility 
Soluble in water. Insoluble in organic solvents.
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
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Safety

Hazard Codes 
T+
Risk Statements 
28
Safety Statements 
28-36/37-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
F 
1-10
HazardClass 
6.1
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
203350
Product name
Blasticidin S, Hydrochloride, Streptomyces griseochromogenes - CAS 589205 - Calbiochem
Packaging
25mg
Price
$216
Updated
2024/03/01
Sigma-Aldrich
Product number
203351-M
Product name
Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem
Purity
sterile; sterile-filtered, suitable for cell culture
Packaging
10ml
Price
$583
Updated
2022/05/15
Sigma-Aldrich
Product number
203351-M
Product name
Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem
Purity
sterile; sterile-filtered, suitable for cell culture
Packaging
203351-10ML
Price
$583
Updated
2022/05/15
Sigma-Aldrich
Product number
15205
Product name
Blasticidine S hydrochloride
Packaging
25MG
Price
$173
Updated
2022/05/15
Sigma-Aldrich
Product number
15205
Product name
Blasticidine S hydrochloride
Packaging
100MG
Price
$476
Updated
2022/05/15
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BLASTICIDIN S HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1?Inhibits translation by trapping deformed tRNA on the ribosome.1?The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in?Pseudomonas aeruginosa?PA14.2?Selection agent for bis, bsr and bsd transformed cells.3,4

Chemical Properties

White powder

Uses

Inhibits protein synthesis and induces apoptosis. Used to study protein synthesis at the level of peptide bond formation.

Uses

Blasticidin S hydrochloride is used to inhibit protein synthesis in prokaryotic and eukaryotic organisms. It also induces apoptosis.

Uses

Blasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations.

General Description

Nucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase gene (bsr) that converts blastisidin S to a nontoxic deaminohydroxy derivative.

storage

Store at -20°C

References

1) Svidritskiy?et al., (2013),?Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome;?Proc. Natl. Acad. Sci. USA?110?12283 2) Pletzer?et al.?(2015),?The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD is Required for Uptake of Peptidyl Nucleoside Antibiotics; J. Bacteriol.?197?2217 3) Asada?et al.?(2015),?Transfection of Babesia bovis by Double Selection with WR99210 and Blasticidin-S and Its Application for Functional Analysis of Thioredoxin Peroxidase-1; PLoS One,?10?e0125993 4) Garg and Qadri (2010),?Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist; J. Immunol.?184?5980

BLASTICIDIN S HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BLASTICIDIN S HYDROCHLORIDE Suppliers

China 96 France 1 Germany 4 India 4 Japan 1 Switzerland 3 United Kingdom 8 United States 24 Global 141
Novachemistry
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44-20819178-90 02081917890
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Carbosynth
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Tocris Bioscience
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Apollo Scientific Ltd.
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Leancare Ltd.
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MOLEKULA Ltd.
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Melford Laboratories Ltd.
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VWR International
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3513-03-9, BLASTICIDIN S HYDROCHLORIDERelated Search:

Clindamycin hydrochloride Cefotaxime sodium MALFORMINC PHLEOMYCIN Geneticin Hygromycin B Ketanserin 5-Azacytidine WAY100635 CHIR-99021 Barasertib (AZD1152-HQPA) BLASTICIDIN S (S)-2-AMINO-BUT-3-EN-1-OL HYDROCHLORIDE L-ALLOISOTHREONINE HCL H-BETA-ALA-BETA-ALA-OH Demethylblasticidin S BLASTICIDIN S HYDROCHLORIDE BLASTICIDIN S HYDROCHLORIDE,BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES

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  • BLASTICIDIN S HYDROCHLORIDE
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  • Blasticidine S HCl
  • Blasticidine S hydrochloride solution
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  • Blasticidin S hydrochloride≥ 98% (HPLC)
  • Blasticidine S hydrochloride Solution, 100ppm
  • (2S,3S,6R)-3-[[(3R)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid,hydrochloride
  • Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem
  • (S)-4-[[3-Amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-hex-2-enopyranuronic acid hydrochloride
  • BLASTICIDIN S 50MG
  • BLASTICIDIN S HYDROCHLORIDE USP/EP/BP
  • Blasticidin S Hydrochloride for cell culture, 98%, Endotoxin (BET) 0.05EU/mg
  • Blasticidin S (10 mg/ml)
  • (2S,3S,6R)-6-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3-((S)-3-amino-5-(1-methylguanidino)pentanamido)-3,6-dihydro-2H-pyran-2-carboxylic acid hydrochloride
  • Blasticidin S (10 mg/mL in Solution)
  • Miewen S hydrochloride
  • BlasticidineSHCl in Acetonitrile:Water=1:1
  • 3513-03-9
  • C17H26N8O5HCl
  • C17H27ClN8O5
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