Meisoindigo

Product Name: Meisoindigo
CAS No.: 97207-47-1
Chemical Name: Meisoindigo
Synonyms: CS-1454;Natura-α;Dian III;MEISOINDIGO;3'-digallate;Theaflavine-3;Meisoindigo, >96%;Methylisoindigotin;Meisoindigo, >=98%;Meisoindigo(Natura-
CBNumber: CB8394558
Molecular Formula: C17H12N2O2
Formula Weight: 276.29
MOL File: 97207-47-1.mol

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Meisoindigo Property

Melting point:: 236-237°C
Boiling point:: 482.0±45.0 °C(Predicted)
Density: 1.381±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: insoluble in H2O; insoluble in EtOH; ≥25.85 mg/mL in DMSO with ultrasonic
form: powder to crystal
pka: 11.62±0.20(Predicted)
color: Orange to Brown to Dark red
InChI: InChI=1S/C17H12N2O2/c1-19-13-9-5-3-7-11(13)15(17(19)21)14-10-6-2-4-8-12(10)18-16(14)20/h2-9H,1H3,(H,18,20)
InChIKey: QNOCRUSVMMAKSC-UHFFFAOYSA-N
SMILES: N1(C)C2=C(C=CC=C2)C(=C2C3=C(NC2=O)C=CC=C3)C1=O

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Safety

HS Code: 2933.79.1500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3082
Product name: Meisoindigo
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $135
Updated: 2025/07/31

TCI Chemical

Product number: M3082
Product name: Meisoindigo
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $369
Updated: 2025/07/31

Cayman Chemical

Product number: 18007
Product name: Meisoindigo
Purity: ≥95%
Packaging: 500μg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18007
Product name: Meisoindigo
Purity: ≥95%
Packaging: 1mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 18007
Product name: Meisoindigo
Purity: ≥95%
Packaging: 5mg
Price: $341
Updated: 2024/03/01

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Meisoindigo Chemical Properties,Usage,Production

Description

Meisoindigo is a derivative of indirubin that has anticancer activity. It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 μM. It also halts the cell cycle at the G₀/G₁ phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine and idarubicin . Meisoindigo (10 μM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells. Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.

Chemical Properties

mp 236-237°C

Uses

Meisoindigo is a 5-HT3 receptor antagonist prevents acute nausea and vomiting associated with emetogenic cancer chemotherapy

Uses

Meisoindigo shows strong anti-proliferation effect against gemcitabine-resistant Pancreatic ductal adenocarcinoma (PDACs).

Synthesis

59-48-3

2058-74-4

97207-47-1

GENERAL METHOD: A mixture of 1-methylisatin (1, 1.0 mmol), 2-indolone (2, 1.0 mmol) and zirconium tetrachloride (ZrCl4, 23 mg, 0.1 mmol) in anhydrous ethanol (5 mL) was heated under reflux conditions. The progress of the reaction was monitored by thin layer chromatography (TLC) and after complete disappearance of the reactants, which usually takes 8-12 h, the reaction mixture was slowly cooled to room temperature. The precipitated red solid was collected by filtration and washed with a small amount of anhydrous ethanol to give pure 1-methyl-[3,3'-bi-indolinylidene]-2,2'-dione (3).

in vivo

Meisoindigo (Dian III; 50-150?mg/kg; IP; daily; for 14 days) has anti-leukemic activity in?vivo^[1].
Meisoindigo (2, 4, 8, 12 mg/kg; IP; before MCAO and 2 h after reperfusion) significantly reduces infarct volume, ameliorates neurological deficits 3 days after middle cerebral artery occlusion (MCAO) in Wild-type C57BL/6J mice (25-30 g). Meisoindigo reduces edema and lowers AQP4 expression in the brain^[2].

Animal Model:	NOD/SCID mice, 6-8 weeks old, with HL-60 leukemic cells^[1]
Dosage:	50, 100, 150?mg/kg
Administration:	IP; daily; for 14 days
Result:	Had anti-leukemic activity in?vivo.

References

[1] lee cc, lin cp, lee yl, wang gc, cheng yc, liu he. meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. leuk lymphoma. 2010 may;51(5):897-905.

Meisoindigo Preparation Products And Raw materials

Raw materials

Preparation Products

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Meisoindigo Suppliers

Americas 1 China 135 Europe 1 Finland 1 Germany 1 India 2 Japan 1 United States 21 Global 163

Target molecule Corp.

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View Lastest Price from Meisoindigo manufacturers

Dideu Industries Group Limited

Product: Meisoindigo 97207-47-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-01

Shaanxi Dideu Medichem Co. Ltd

Product: Meisoindigo 97207-47-1
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 800 tons
Release date: 2020-04-29

Career Henan Chemical Co

Product: Meisoindigo 97207-47-1
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

97207-47-1, MeisoindigoRelated Search:

Methyl acrylate Acetonitrile cis-Octahydro-isoindole 1-(2,6-Dichlorophenyl)-2-hydroindole 4-Methyl-2-pentanone Dihydromyrcenol Basic Violet 1 Methyl tetrahydrophthalic anhydride Methanol Mesotrione Paraquat dichloride Methylparaben Tetramethylammonium hydroxide Kresoxim-methyl Methyl 2-Butanone Indole Meisoindigo

1-METHYL-3,3'-BIINDOLE-2,2'(1H,1'H)-DIONE

3-(1,2-dihydro-2-oxo-3h-indol-3-ylidene)-1,3-dihydro-1-methyl-2h-indol-2-one

MEISOINDIGO

N-methylisoindigotin

Dian III

Methylisoindigotin

Natura-α

Meisoindigo 3-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-2H-indol-2-one

Methylisoindigotin Meisoindigo

Meisoindigo, >=98%

Meisoindigo, >96%

CS-1454

Meisoindigo(Natura-

DIAN III; N-METHYLISOINDIGOTIN; NATURA-Α

2H-Indol-2-one, 3-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-

(3E)-1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one

Meisoindigo USP/EP/BP

1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one

3'-digallate

Theaflavine-3

(E)-1-methyl-[3,3'-biindolinylidene]-2,2'-dione

1-Methyl-[3,3'-biindolinylidene]-2,2'-dione

Meisoindigo, 10 mM in DMSO

(e)-[3,3'-biindolinylidene]-2,2'-dione compound with methyl-l2-stannane (1:1)

97207-47-1

97207-41-1

Inhibitors