ChemicalBook > CAS DataBase List > 5-Isoquinolinesulfonic acid

5-Isoquinolinesulfonic acid

Product Name
5-Isoquinolinesulfonic acid
CAS No.
27655-40-9
Chemical Name
5-Isoquinolinesulfonic acid
Synonyms
0.99;5-SULFOISOQUINOLINE;Fasudil Impurity 35;Isoquinoline-5-sulfo;5-Sulphoisoquinoline;-5- isoquinolineacid;Isoquinoline-5-sulfonic;Isoquinolinesulfonic acid;isoquinoline-5-sulfonicaci;5-ISOQUINOLINESULFONIC ACID
CBNumber
CB8395126
Molecular Formula
C9H7NO3S
Formula Weight
209.22
MOL File
27655-40-9.mol
More
Less

5-Isoquinolinesulfonic acid Property

Melting point:
>300 °C (lit.)
Density 
1.4048 (rough estimate)
refractive index 
1.5364 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
-0.98±0.40(Predicted)
form 
Solid
color 
White to Almost white
InChI
InChI=1S/C9H7NO3S/c11-14(12,13)9-3-1-2-7-6-10-5-4-8(7)9/h1-6H,(H,11,12,13)
InChIKey
YFMJTLUPSMCTOQ-UHFFFAOYSA-N
SMILES
C1C2=C(C(S(O)(=O)=O)=CC=C2)C=CN=1
CAS DataBase Reference
27655-40-9(CAS DataBase Reference)
EPA Substance Registry System
5-Isoquinolinesulfonic acid (27655-40-9)
More
Less

Safety

Hazard Codes 
T,C,Xi
Risk Statements 
49-23-34-24-36/38
Safety Statements 
53-26-27-36/37/39-45
RIDADR 
UN 2585 8/PG 3
WGK Germany 
1
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29334900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
246123
Product name
5-Isoquinolinesulfonic acid
Purity
95%
Packaging
5g
Price
$55.3
Updated
2023/06/20
Sigma-Aldrich
Product number
246123
Product name
5-Isoquinolinesulfonic acid
Purity
95%
Packaging
25g
Price
$90
Updated
2023/06/20
TCI Chemical
Product number
I0470
Product name
Isoquinoline-5-sulfonic Acid
Purity
>96.0%(HPLC)(T)
Packaging
25g
Price
$53
Updated
2025/07/31
TCI Chemical
Product number
I0470
Product name
Isoquinoline-5-sulfonic Acid
Purity
>96.0%(HPLC)(T)
Packaging
250g
Price
$318
Updated
2025/07/31
TRC
Product number
I875000
Product name
Isoquinoline-5-sulfonic Acid
Packaging
50g
Price
$165
Updated
2021/12/16
More
Less

5-Isoquinolinesulfonic acid Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

5-Isoquinolinesulfonic acid was used in the synthesis of conjugates of oligoarginine peptides.

Synthesis

105627-79-0

27655-40-9

The general procedure for the synthesis of 5-isoquinolinesulfonic acid from isoquinoline-5-sulfonyl chloride hydrochloride was as follows: the synthesis of compound 3i was carried out according to the method reported in the literature [56,57]. The procedure was as follows: 5-isoquinolinesulfonic acid (2.10 g, 10 mmol), 25 mL of thionyl chloride, and 1 mL of dimethylformamide were added to a 100 mL round-bottomed flask, and the mixture was refluxed for 1 hour. Upon completion of the reaction, the remaining thionyl chloride was removed by rotary evaporation, and the residue was suspended in dichloromethane, filtered, and washed with dichloromethane (2 x 25 mL). The precipitate was collected and dried under vacuum to give the crude isoquinoline-5-sulfinyl chloride hydrochloride in 85% yield (2.25 g). Next, isoquinoline-5-sulfonyl chloride hydrochloride (2.0 g, 7.6 mmol) and 20 mL of ice-cold deionized water were added to another 100 mL round bottom flask. The mixture was slowly added to an equimolar amount of sodium bicarbonate (0.64 g) and the resulting solution was extracted twice with dichloromethane (2 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate, and then added dropwise to 25 mL of dichloromethane solution containing ethylenediamine (1.37 g, 22.8 mmol) at 0°C. The reaction was continued with stirring at room temperature for 1 h. The reaction was subsequently washed with deionized water to remove excess ethylenediamine and finally the solvent was evaporated. The residue was recrystallized from ethanol to give pure compound 3i in 55% yield.

References

[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 18, p. 5694 - 5706

5-Isoquinolinesulfonic acid Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID Isoquinoline Sodium hydroxide Sulfuric acid

Preparation Products

More
Less

5-Isoquinolinesulfonic acid Suppliers

Americas 1 Belgium 1 Canada 1 China 307 Europe 3 Germany 3 India 9 Japan 7 Slovakia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 11 United States 26 Global 374
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892 13376080562
Fax
025-85766769
Email
sales@habotech.com
Country
China
ProdList
884
Advantage
60
Tocopharm Co., Ltd.
Tel
+86-021-69895597 13776836200 +86-13776836200
Fax
021-61292409
Email
tocopharm@gmail.com
Country
China
ProdList
196
Advantage
55
New Energy Chemicals
Tel
0515-82159099 13770142076
Fax
86-0515-8215909
Email
info@njuchem.com
Country
China
ProdList
242
Advantage
65
Shangqiu Huakang Zhongbang Biotechnology Co., Ltd
Tel
13011705167
Email
3838015797@qq.com
Country
China
ProdList
154
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
ITIC MEDCHEM(SUZHOU) CO.,LTD.
Tel
0512-68323967 18015559028
Fax
+86-512-69200360
Email
sales@iticmedchem.com
Country
China
ProdList
506
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9309
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
3997
Advantage
55
Suzhou Guide Fine Material Co.Ltd.
Tel
0512-66627360 13914021065
Fax
0512-66627360
Email
706938434@qq.com
Country
China
ProdList
239
Advantage
60
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5645
Advantage
65
Chengdu Forest Science and Technology Development Co., Ltd.
Tel
18030648795
Fax
028-61777050
Email
sales@cdforestchem.com
Country
China
ProdList
2000
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
RiZhao LiDeShi Chemical Co., Ltd.
Tel
010-51268198
Fax
010-63833209
Email
leadershipchem@126.com
Country
China
ProdList
2546
Advantage
58
Zhengzhou HongSheng Pharmaceutical Co., Ltd.
Tel
0371-0371-13526885213 15637198702
Fax
0371-63709726
Email
hsyykjchem@163.com
Country
China
ProdList
3852
Advantage
58
Mei Lan Industrial (Shanghai) Co., Ltd.
Tel
021-58958189
Fax
021-58957967
Email
wouchina@126.com
Country
China
ProdList
2666
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Chengdu Firster Pharmaceutical Co., Ltd.
Tel
028-87078428 028-87074958
Fax
8772-8116
Email
chengzhenyong@cdfirster.com
Country
China
ProdList
2598
Advantage
60
Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
3027
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
GuangTuo Chemical (Shanghai) Co., Ltd.
Tel
021-60899189-8001 18918189673
Fax
021-60899304
Email
gtchem@126.com
Country
China
ProdList
2656
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
More
Less

View Lastest Price from 5-Isoquinolinesulfonic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Isoquinolinesulfonic acid 27655-40-9
Price
US $19.90/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-14
Henan Aochuang Chemical Co.,Ltd.
Product
5-Isoquinolinesulfonic acid 27655-40-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-12
Baoji Guokang Healthchem co.,ltd
Product
5-Isoquinolinesulfonic acid 27655-40-9
Price
US $476.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KG
Release date
2021-06-04

27655-40-9, 5-Isoquinolinesulfonic acidRelated Search:

Taurine Ethyl 2-(Chlorosulfonyl)acetate 5,6,7,8-TETRAHYDROISOQUINOLINE 1-DODECANESULFONIC ACID SODIUM SALT Sulfamic acid Isoquinoline p-Toluenesulfonic acid Folic acid Glycine QUINOLINE-8-SULFONIC ACID Isomalt ISOQUINOLINE-5-SULFONYL CHLORIDE Fasudil Impurity 21 1-(p-Toluenesulfonyl)hoMopiperazine, 95% 1,4-ditosyl-1,4-diazepane Fasudil Impurity 24 Fasudil Impurity 10 Fasudil diMer

  • 5-SULFOISOQUINOLINE
  • ISOQUINOLINE-5-SULFONIC ACID
  • ISOQUINOLINE-5-SULFONIC ACID FOR SINTESIS
  • ISOQUINOLINE-5-SULPHONIC ACID
  • 5-ISOQUINOLINESULFONIC ACID
  • 5-ISOQUINOLINESULFONIC ACID MONOHYDRATE
  • 5-ISOQUINOLINESULPHONIC ACID
  • Fasudil Impurity 35
  • Isoquinoline-5-SulphonicAcid99%
  • Isoquinoline-5-Sulphonic Acid 99%
  • Isoquinoline-5-sulfonic
  • 5-ISOQUINOLINESULFONIC ACID 98+%
  • 5-Isoquinolinesulfonic acid ,95%
  • Isoquinolinesulfonic acid
  • 5-Isoquinolinesulfonic acid ,99%
  • Isoquinoline-5-sulfo
  • 5-Sulphoisoquinoline
  • 5-Isoquinolinesulfonic acid, 95% 5GR
  • ISOQUINOLINE-5-SULFONIC ACID FOR SYNTHES
  • -5- isoquinolineacid
  • 5-Isoquinolinesulfonic acid 95%
  • 5-Isoquinolinesulfonic acid, 99.9%
  • 0.99
  • Isoquinoline-5-sulfonic acid for synthesis
  • Isoquinoline-5-sulfonicAcid&gt
  • isoquinoline-5-sulfonicaci
  • 5-Isoquinolinesulfonic acid ISO 9001：2015 REACH
  • 5-Isoquinolinesulfonic acid (7CI, 8CI, 9CI, ACI)
  • 27655-40-9
  • 27655-40-6
  • C9H7NO3S
  • Isoquinolines
  • Heterocyclic Building Blocks
  • Building Blocks
  • Building Blocks
  • Heterocyclic Building Blocks
  • Isoquinolines
  • Aromatics
  • Sulfur & Selenium Compounds
  • Quinolines, Isoquinolines & Quinoxalines
  • Quinolines, Isoquinolines & Quinoxalines
  • Organic acids
  • Aromatics Compounds