5-Isoquinolinesulfonic acid
- Product Name
- 5-Isoquinolinesulfonic acid
- CAS No.
- 27655-40-9
- Chemical Name
- 5-Isoquinolinesulfonic acid
- Synonyms
- 0.99;5-SULFOISOQUINOLINE;Fasudil Impurity 35;Isoquinoline-5-sulfo;5-Sulphoisoquinoline;-5- isoquinolineacid;Isoquinoline-5-sulfonic;Isoquinolinesulfonic acid;isoquinoline-5-sulfonicaci;5-ISOQUINOLINESULFONIC ACID
- CBNumber
- CB8395126
- Molecular Formula
- C9H7NO3S
- Formula Weight
- 209.22
- MOL File
- 27655-40-9.mol
5-Isoquinolinesulfonic acid Property
- Melting point:
- >300 °C (lit.)
- Density
- 1.4048 (rough estimate)
- refractive index
- 1.5364 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- -0.98±0.40(Predicted)
- form
- Solid
- color
- White to Almost white
- InChI
- InChI=1S/C9H7NO3S/c11-14(12,13)9-3-1-2-7-6-10-5-4-8(7)9/h1-6H,(H,11,12,13)
- InChIKey
- YFMJTLUPSMCTOQ-UHFFFAOYSA-N
- SMILES
- C1C2=C(C(S(O)(=O)=O)=CC=C2)C=CN=1
- CAS DataBase Reference
- 27655-40-9(CAS DataBase Reference)
- EPA Substance Registry System
- 5-Isoquinolinesulfonic acid (27655-40-9)
Safety
- Hazard Codes
- T,C,Xi
- Risk Statements
- 49-23-34-24-36/38
- Safety Statements
- 53-26-27-36/37/39-45
- RIDADR
- UN 2585 8/PG 3
- WGK Germany
- 1
- Hazard Note
- Toxic
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29334900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H290May be corrosive to metals
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P234Keep only in original container.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 246123
- Product name
- 5-Isoquinolinesulfonic acid
- Purity
- 95%
- Packaging
- 5g
- Price
- $55.3
- Updated
- 2023/06/20
- Product number
- 246123
- Product name
- 5-Isoquinolinesulfonic acid
- Purity
- 95%
- Packaging
- 25g
- Price
- $90
- Updated
- 2023/06/20
- Product number
- I0470
- Product name
- Isoquinoline-5-sulfonic Acid
- Purity
- >96.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $53
- Updated
- 2025/07/31
- Product number
- I0470
- Product name
- Isoquinoline-5-sulfonic Acid
- Purity
- >96.0%(HPLC)(T)
- Packaging
- 250g
- Price
- $318
- Updated
- 2025/07/31
- Product number
- I875000
- Product name
- Isoquinoline-5-sulfonic Acid
- Packaging
- 50g
- Price
- $165
- Updated
- 2021/12/16
5-Isoquinolinesulfonic acid Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Solid
Uses
5-Isoquinolinesulfonic acid was used in the synthesis of conjugates of oligoarginine peptides.
Synthesis
105627-79-0
27655-40-9
The general procedure for the synthesis of 5-isoquinolinesulfonic acid from isoquinoline-5-sulfonyl chloride hydrochloride was as follows: the synthesis of compound 3i was carried out according to the method reported in the literature [56,57]. The procedure was as follows: 5-isoquinolinesulfonic acid (2.10 g, 10 mmol), 25 mL of thionyl chloride, and 1 mL of dimethylformamide were added to a 100 mL round-bottomed flask, and the mixture was refluxed for 1 hour. Upon completion of the reaction, the remaining thionyl chloride was removed by rotary evaporation, and the residue was suspended in dichloromethane, filtered, and washed with dichloromethane (2 x 25 mL). The precipitate was collected and dried under vacuum to give the crude isoquinoline-5-sulfinyl chloride hydrochloride in 85% yield (2.25 g). Next, isoquinoline-5-sulfonyl chloride hydrochloride (2.0 g, 7.6 mmol) and 20 mL of ice-cold deionized water were added to another 100 mL round bottom flask. The mixture was slowly added to an equimolar amount of sodium bicarbonate (0.64 g) and the resulting solution was extracted twice with dichloromethane (2 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate, and then added dropwise to 25 mL of dichloromethane solution containing ethylenediamine (1.37 g, 22.8 mmol) at 0°C. The reaction was continued with stirring at room temperature for 1 h. The reaction was subsequently washed with deionized water to remove excess ethylenediamine and finally the solvent was evaporated. The residue was recrystallized from ethanol to give pure compound 3i in 55% yield.
References
[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 18, p. 5694 - 5706
5-Isoquinolinesulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Isoquinolinesulfonic acid Suppliers
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View Lastest Price from 5-Isoquinolinesulfonic acid manufacturers
- Product
- 5-Isoquinolinesulfonic acid 27655-40-9
- Price
- US $19.90/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-14
- Product
- 5-Isoquinolinesulfonic acid 27655-40-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12
- Product
- 5-Isoquinolinesulfonic acid 27655-40-9
- Price
- US $476.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KG
- Release date
- 2021-06-04