ChemicalBook > CAS DataBase List > 2'-O-Methyluridine

2'-O-Methyluridine

Product Name
2'-O-Methyluridine
CAS No.
2140-76-3
Chemical Name
2'-O-Methyluridine
Synonyms
1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxyMethyl)-3-Methoxytetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione;OMe-rU;2'-OMe-Ur;2'-OMe-rU;2'-O-Me-U;2'-OMe-Ur;2'-OMe Uridine;2-Methyoxy uridine;2'-O-METHYLURIDINE;2'-O-Methyluridine
CBNumber
CB8397539
Molecular Formula
C10H14N2O6
Formula Weight
258.23
MOL File
2140-76-3.mol
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2'-O-Methyluridine Property

Melting point:
154-156°C
Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.39±0.10(Predicted)
form 
Powder
color 
White to Off-white
PH
～9.3
λmax
261nm(MeOH)(lit.)
InChI
InChI=1S/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1
InChIKey
SXUXMRMBWZCMEN-ZOQUXTDFSA-N
SMILES
OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1O
CAS DataBase Reference
2140-76-3(CAS DataBase Reference)
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
24/25
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2290
Product name
2'-O-Methyluridine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$65
Updated
2024/03/01
TCI Chemical
Product number
M2290
Product name
2'-O-Methyluridine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$195
Updated
2024/03/01
Alfa Aesar
Product number
J64897
Product name
2'-O-Methyluridine, 99%
Packaging
1g
Price
$33.3
Updated
2023/06/20
TRC
Product number
M338200
Product name
2''-O-MethylUridine
Packaging
50g
Price
$1245
Updated
2021/12/16
AK Scientific
Product number
AMTA036
Product name
2'-Methoxy-2'-deoxyuridine
Packaging
250mg
Price
$25
Updated
2021/12/16
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2'-O-Methyluridine Chemical Properties,Usage,Production

Description

2'-O-Methyluridine is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. This compound also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands.

Chemical Properties

White Solid

Uses

Uridine analog. Used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.

Uses

Uridine analog. 2'-O-Methyluridine is used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.

Definition

ChEBI: A methyluridine that consists of uridine bearing a single methyl substituent located at position O-2' on the ribose ring.

Source

2'-O-Methyluridine is found in rRNA, snRNA, snoRNA and tRNA of Archaea, Bacteria, and Eukaryota[1].

References

[1] Agota Au?ynait?. “Identification of a 2’-O-Methyluridine Nucleoside Hydrolase Using the Metagenomic Libraries.” Molecules 23 11 (2018).

2'-O-Methyluridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-O-Methyluridine Suppliers

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View Lastest Price from 2'-O-Methyluridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2'-O-Methyluridine 2140-76-3
Price
US $0.00/Kg/Bag
Min. Order
100g
Purity
98%min HPLC
Supply Ability
10KGS
Release date
2021-06-28
Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
2'-O-Methyluridine 2140-76-3
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98
Supply Ability
1000
Release date
2025-01-03
Hefei Huana Biomedical Technology Co.,Ltd.
Product
2'-OME-rU 2140-76-3
Price
US $0.00/g
Min. Order
100g
Purity
≥98%(HPLC)
Supply Ability
20t
Release date
2023-03-23

2140-76-3, 2'-O-MethyluridineRelated Search:

(Trifluoromethoxy)benzene Trifluridine Doxifluridine 2',3',5'-Tri-O-acetyluridine uridine diphosphate glucose {= UDP-glucose} Methyluridine 2',3',5'-TRI-O-BENZOYLURIDINE 2′,3′-O-Isopropylideneuridine 5-METHY-5-METHYLURIDINE,5-METHYL-2'-O-METHYLURIDINE,2'-O-METHYL-5-METHYLURIDINE 2'-O-Methyl-5'-O-DMT-Uridine 2'-OMe-U-CE Phosphoramidite DMT-2'O-Methyl-rU Phosphoramidite 2,2'-ANHYDRO-5-METHYLURIDINE,2,2'β-Oxy-2-deoxo-2,3-didehydro-2'-deoxy-5-methyluridine,O2,2'-Anhydro-5-methyluridine 2'-DEOXY-2'-FLUORO-5-METHYLURIDINE 3-METHYLURIDINE 2'-C-Methyluridine 3',5'-DI-O-BENZOYL-5-FLUORO-2'-O-METHYLURIDINE 5'-O-(DMT)-5-IODO-2'-O-METHYLURIDINE

  • 2'-O-METHYLURIDINE (CHIRAL)
  • 2''-O-METHYLURIDINE CRYSTALLINE
  • 1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone
  • 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidine-2,4-dione
  • 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione
  • 2'-O-METHYLURIDINE
  • 1-[(2R,3R,4R,5R)-4-HYDROXY-5-(HYDROXYMETHYL)-3-METHOXYOXOLAN-2-YL]-3H-PYRIMIDINE-2,4-DIONE
  • 2'-O-Methyluridine 98+%
  • 2'-O-Methyluridine, 98.0 %
  • 2-Methyoxy uridine
  • 1-[(2S,3S,4R,5S)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione
  • 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxyMethyl)-3-Methoxytetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
  • 1-(2-O-Methyl-beta-D-ribofuranosyl)uracil
  • 2'-OMe-Ur
  • 2'-O-Methyluridine&gt
  • Uridine, 2'-O-methyl-
  • 2'-OMe-rU
  • 2'-O-Methyluridine USP/EP/BP
  • 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • 2’-O-Methyl uridine, RNA modified nucleoside Um
  • RNA modified nucleoside Um
  • 1-((2S,3S,4S,5S)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
  • 2 '- Methoxyuridine
  • OMe-rU
  • 2'-O-Methyluridine
  • 2'-OMe Uridine
  • 2'-O-Me-U
  • 2'-OMe-Ur
  • 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxy- tetrahydrofuran-2-yDpyrimidine-2,4(1H,3H)-dione
  • 2’-Methyoxy uridine
  • 2140-76-3
  • 2140-79-3
  • 2104-76-3
  • pyrimidine
  • Heterocycle-Pyrimidine series
  • Bases & Related Reagents
  • Carbohydrates & Derivatives
  • Heterocycles
  • Nucleotides
  • Pharmaceutical
  • 2140-76-3
  • Nucleosides
  • Modified（deoxy）nucleoside
  • Nucleosides-2'-OMe Nucleosides