tert-Butyl 4-methylenepiperidine-1-carboxylate

Product Name: tert-Butyl 4-methylenepiperidine-1-carboxylate
CAS No.: 159635-49-1
Chemical Name: tert-Butyl 4-methylenepiperidine-1-carboxylate
Synonyms: TERT-BUTYL 4-METHYLENEPIPERIDINE-1-CARBOXYLATE;tert-butyl 4-methylidenepiperidine-1-carboxylate;4-METHY;enepiperidine;N-Boc-4-MethyL;1-Boc-4-Methylenepip;Boc-4-methylenepiperidine;1-Boc-4-methylenepiperidin;N-BOC-4-METHYLENEPIPERIDINE;1-Boc-4-Methylene-piperidine
CBNumber: CB8411855
Molecular Formula: C11H19NO2
Formula Weight: 197.27
MOL File: 159635-49-1.mol

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tert-Butyl 4-methylenepiperidine-1-carboxylate Property

Boiling point:: 80°C/1mmHg(lit.)
Density: 1g/ml
refractive index: 1.4630 to 1.4670
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: liquid
pka: -1.41±0.20(Predicted)
color: Clear, colourless
InChI: InChI=1S/C11H19NO2/c1-9-5-7-12(8-6-9)10(13)14-11(2,3)4/h1,5-8H2,2-4H3
InChIKey: PDTZMULNKGUIEJ-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(=C)CC1
CAS DataBase Reference: 159635-49-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4809
Product name: 1-tert-Butoxycarbonyl-4-methylenepiperidine
Purity: >96.0%(GC)
Packaging: 1g
Price: $90
Updated: 2021/12/16

TCI Chemical

Product number: B4809
Product name: 1-tert-Butoxycarbonyl-4-methylenepiperidine
Purity: >96.0%(GC)
Packaging: 5g
Price: $347
Updated: 2022/04/27

TRC

Product number: B809533
Product name: tert-Butyl4-Methylenepiperidine-1-carboxylate
Packaging: 1g
Price: $55
Updated: 2021/12/16

TRC

Product number: B809533
Product name: tert-Butyl4-Methylenepiperidine-1-carboxylate
Packaging: 5g
Price: $75
Updated: 2021/12/16

TRC

Product number: B809533
Product name: tert-Butyl4-Methylenepiperidine-1-carboxylate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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tert-Butyl 4-methylenepiperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

tert-Butyl 4-Methylenepiperidine-1-carboxylate is a useful reagent for the design of anion exchange membranes (AEMs) and ionomers for use in storage devices such as fuel cells and batteries.

Synthesis

1779-49-3

79099-07-3

159635-49-1

Generalized method: Step 1: Synthesis of tert-butyl 4-methylene piperidine-1-carboxylate To a suspension of methyltriphenylphosphonium bromide (36.3 g, 101.6 mmol, 1.35 eq.) in dry ether (300 mL) was added potassium tert-butoxide (1 g, 98 mmol, 1.3 eq.) in a single addition at 0°C under nitrogen protection. The mixture was heated to reflux and stirred for 2 hours. Subsequently, the reaction mixture was cooled to 0 °C using an external ice bath and a solution of N-tert-butoxycarbonyl-4-piperidone (15 g, 75.3 mmol, 1.0 equiv) in ether (60 mL) was added dropwise. The mixture was slowly warmed to room temperature and stirring was continued at this temperature for 1 hour. After that, the mixture was heated to reflux again and stirred overnight (16 hours). Upon completion of the reaction, the mixture was cooled to room temperature, hexane (300 mL) was added, stirred for 10 minutes, filtered, and eluted with a solvent mixture of hexane/EtOAc (100/100 mL). The organic phases were combined and concentrated to give the crude product, which was finally purified by a CombiFlash system (100 g silica gel column, EtOAc/Hexane gradient elution, 0-30%) to give 14 g (94% yield) of tert-butyl 4-methylene piperidine-1-carboxylate as a colorless oil. 1H NMR (400 MHz, CDCl3): δ 4.74 (s, 2H), 3.42 (t, 4H), 2.18 (t, 4H), 1.47 (s, 9H).

References

[1] Patent: CN103635456, 2016, B. Location in patent: Paragraph 0270-0272; 0381-0383
[2] Patent: CN106674112, 2017, A. Location in patent: Paragraph 0035-0036
[3] Patent: WO2013/13308, 2013, A1. Location in patent: Paragraph 00196-00198
[4] Patent: US2010/222324, 2010, A1. Location in patent: Page/Page column 55
[5] Patent: US2010/234340, 2010, A1. Location in patent: Page/Page column 42

tert-Butyl 4-methylenepiperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 4-methylenepiperidine-1-carboxylate Suppliers

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View Lastest Price from tert-Butyl 4-methylenepiperidine-1-carboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: tert-Butyl 4-methylenepiperidine-1-carboxylate 159635-49-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Career Henan Chemical Co

Product: 1-Boc-4-methylenepiperidine 159635-49-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 500kg
Release date: 2018-08-17

159635-49-1, tert-Butyl 4-methylenepiperidine-1-carboxylateRelated Search:

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TERT-BUTYL 4-METHYLENEPIPERIDINE-1-CARBOXYLATE

N-BOC-4-METHYLENEPIPERIDINE

1-Boc-4-Methylene-piperidine

4-Methylenepiperidine, N-BOC protected 97%

Boc-4-methylenepiperidine

1-N-BOC-4-METHYLENE-PIPERIDINE 98+%

4-METHYLENE-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

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1-N-BOC-4-METHYLENE-PIPERIDINE

1-Piperidinecarboxylic acid, 4-Methylene-, 1,1-diMethylethyl ester

t-butyl 4-Methylenetetrahydropyridine-1(2H)-carboxylate

1-Boc-4-Methylenepip

4-methylenetetrahydropyridine-1(2H)-carboxylate

tert-Butyl 4-methylidenepiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-methylidenepiperidine

tert-butyl 4-methylidenepiperidine-1-carboxylate

1-tert-Butoxycarbonyl-4-methylenepiperidine

1-<i>tert</i>-Butoxycarbonyl-4-methylenepiperidine

4-METHY

1-tert-Butoxycarbonyl-4-methylenepiperidine &gt

N-Boc-4-MethyL

enepiperidine

t-Bu-4-methylenepiperidine-1-carbox

tert-Butyl 4-methylenepiperidin-1-carboxylate

Efinaconazole intermediate -1-Boc-4-methylene piperidine

1-Boc-4-methylenepiperidin

1-N-Boc-4-methylenepiperidine, 96%

N-Boc-4-methylidenepiperidine

Controlled Substance(Efinaconazole Impurity 17)

159635-49-1

C11H19NO2

pharmacetical

Pyrans, Piperidines &Piperazines

Piperidine

Heterocyclic Compounds

Pyrans, Piperidines & Piperazines