ChemicalBook > CAS DataBase List > Pyrimidine-5-carboxaldehyde

Pyrimidine-5-carboxaldehyde

Product Name
Pyrimidine-5-carboxaldehyde
CAS No.
10070-92-5
Chemical Name
Pyrimidine-5-carboxaldehyde
Synonyms
PYRIMIDINE-5-CARBALDEHYDE;5-PYRIMIDINECARBOXALDEHYDE;5-FORMYLPYRIMIDINE;RARECHEM AK ML 0565;PyriMidin-5-carbaldehyde;5-Pyrimidinecarbaldehyde;Pyrimidine-5-formaldehyde;PYRIMIDINE-5-CARBOXALDEHYDE;PYRIMIDINE-5-CARBOXYALDEHYDE;Pyrimidine-5-carboxylaldehyde
CBNumber
CB8412180
Molecular Formula
C5H4N2O
Formula Weight
108.1
MOL File
10070-92-5.mol
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Pyrimidine-5-carboxaldehyde Property

Melting point:
39-43°C
Boiling point:
80-82°C 4mm
Density 
1.23
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka
1.15±0.10(Predicted)
form 
solid
color 
Light yellow to yellow
InChI
InChI=1S/C5H4N2O/c8-3-5-1-6-4-7-2-5/h1-4H
InChIKey
FREJAOSUHFGDBW-UHFFFAOYSA-N
SMILES
C1=NC=C(C=O)C=N1
CAS DataBase Reference
10070-92-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-43-22
Safety Statements 
26-36/37/39-36-36/37
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS004733
Product name
pyrimidine-5-carboxaldehyde
Purity
Aldrich<SUP>CPR</SUP>
Packaging
100 mg
Price
$87.5
Updated
2025/07/31
TRC
Product number
P997265
Product name
5-Pyrimidinecarboxaldehyde
Packaging
5g
Price
$925
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
P1680
Product name
5-Formylpyrimidine
Purity
>97%
Packaging
25g
Price
$373
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0032010
Product name
PYRIMIDINE-5-CARBOXALDEHYDE
Purity
95.00%
Packaging
100MG
Price
$739.2
Updated
2021/12/16
AK Scientific
Product number
G603
Product name
Pyrimidine-5-carbaldehyde
Packaging
100g
Price
$1154
Updated
2021/12/16
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Pyrimidine-5-carboxaldehyde Chemical Properties,Usage,Production

Uses

Pyrimidine-5-carboxaldehyde is used in the preparation of (S)- and (R)-pyrimidyl alkanol by reacting with diisopropylzinc and (n-butyl)ethyl(n-hexyl)(n-propyl)methane.

Synthesis

Under nitrogen, a solution of 5-bromopyrimidine (1 g, 6.3 mmol) in 60 mL anhydrous THF was added BuLi (2.5 M, 2.6 mL, 6.5 mmol) at -78° C. The resulting yellow solution was stirred for 20 min, after which ethyl formate (0.55 mL, 6.7 mmol) was added dropwise over 5 min. After 20 min, the reaction was quenched with 1.5 M THF/HCl solution (4.5 mL, 6.7 mmol). The cold bath was removed, and the reaction mixture was stirred for 1 h. THF was removed in vacco, 10 mL of water was then added. The mixture was extracted with CHCl3 (2*10 mL), and the combined organics were dried (MgSO4) and concentrated. The crude product was purified via flash column chromatography (5 per cent MeOH/CHCl3) to give 0.35 g (51 per cent) of the titled Pyrimidine-5-carboxaldehyde.

References

[1] Journal of medicinal chemistry, 2004, vol. 47, # 20, p. 4829 - 4837
[2] Patent: US2005/70712, 2005, A1. Location in patent: Page/Page column 42
[3] Patent: US2005/171131, 2005, A1. Location in patent: Page/Page column 41
[4] Patent: US9212138, 2015, B2. Location in patent: Page/Page column 42
[5] ChemMedChem, 2017, vol. 12, # 3, p. 257 - 270

Pyrimidine-5-carboxaldehyde Preparation Products And Raw materials

Raw materials

Nitrogen Ethyl formate Tetrahydrofuran Diethyl ether Ethyl acetate Hydrochloric acid 5-Bromopyrimidine Magnesium sulfate PETROLEUM ETHER n-Butyllithium

Preparation Products

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View Lastest Price from Pyrimidine-5-carboxaldehyde manufacturers

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
Pyrimidine-5-carboxaldehyde 10070-92-5
Price
US $0.00/kg
Min. Order
1kg
Purity
95%
Supply Ability
5-10 MTs
Release date
2024-05-10
Dideu Industries Group Limited
Product
Pyrimidine-5-carboxaldehyde 10070-92-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons
Release date
2022-02-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
Pyrimidine-5-carbaldehyde 10070-92-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

10070-92-5, Pyrimidine-5-carboxaldehydeRelated Search:

Formaldehyde Sulfadiazine Fluorocytosine Pyrimidine Uracil Silver sulfadiazine 5-METHYLCYTOSINE PYRIMIDINE-4-CARBOXALDEHYDE Pyrimidine-5-boronic acid pinacol ester 2-Pyrimidinecarboxamide (6CI,7CI,9CI) Pyrimidine-2-carboxylic acid 5-Pyrimidinecarboxylic acid Pyrrole-2-carboxaldehyde PYRROLE-2-CARBONITRILE Pyrrole-2-carboxylic acid 5-PYRIMIDINECARBOXAMIDE PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER 4,6-PYRIMIDINE DICARBOXYLIC ACID

  • 5-FORMYLPYRIMIDINE
  • RARECHEM AK ML 0565
  • PYRIMIDINE-5-CARBOXYALDEHYDE
  • PYRIMIDINE-5-CARBALDEHYDE
  • PYRIMIDINE-5-CARBOXALDEHYDE
  • 5-PYRIMIDINECARBOXALDEHYDE
  • 5-Pyrimidinecarboxaldehyde (7CI,8CI,9CI)
  • 5-Pyrimidinecarbaldehyde
  • Pyrimidine-5-carboxylaldehyde
  • PyriMidin-5-carbaldehyde
  • 5-Formylpyrimidine, 5-Formyl-1,3-diazine
  • PyriMidine-5-carbaldehyde 5-ForMylpyriMidine
  • Pyrimidine-5-carboxaldehyde ISO 9001：2015 REACH
  • Pyrimidine-5-formaldehyde
  • 10070-92-5
  • Heterocycle-Pyrimidine series
  • Aromatics
  • Heterocycles
  • PYRIMIDINE
  • Aldehyde
  • Building Blocks
  • Pyrimidines
  • Boronic Acid
  • Heterocyclic Compounds