ChemicalBook > CAS DataBase List > 2-Methylamino-3-nitro-6-chloropyridine
2-Methylamino-3-nitro-6-chloropyridine
- Product Name
- 2-Methylamino-3-nitro-6-chloropyridine
- CAS No.
- 33742-70-0
- Chemical Name
- 2-Methylamino-3-nitro-6-chloropyridine
- Synonyms
- 2-METHYLAMINO-3-NITRO-6-CHLORO;2-Chloro-5-nitro-6-methylaminopyridine;2-Methylamino-3-nitro-6-chloropyridine;6-Chloro-N-methyl-3-nitro-2-pyridinamine;2-Chloro-6-(methylamino)-5-nitropyridine;6-Chloro-2-(methylamino)-3-nitropyridine;6-Chloro-2-(N-methylamino)-3-nitropyridine;2-PYRIDINAMINE, 6-CHLORO-N-METHYL-3-NITRO-;Pyridine, 6-chloro-2-(methylamino)-3-nitro-;(6-Chloro-3-nitro-pyridin-2-yl)-Methyl-aMine
- CBNumber
- CB8421232
- Molecular Formula
- C6H6ClN3O2
- Formula Weight
- 187.58
- MOL File
- 33742-70-0.mol
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2-Methylamino-3-nitro-6-chloropyridine Property
- Melting point:
- 114 °C
- Boiling point:
- 330 °C
- Density
- 1.489
- Flash point:
- 153 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- -0.67±0.10(Predicted)
- Appearance
- White to yellow Solid
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Safety
- HS Code
- 2933399990
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N-Bromosuccinimide Price
TRC
- Product number
- C349770
- Product name
- 6-Chloro-2-(N-methylamino)-3-nitropyridine
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H55-5-42
- Product name
- 2-Chloro-5-nitro-6-methylaminopyridine
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $122
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 126420
- Product name
- 6-Chloro-N-methyl-3-nitropyridin-2-amine
- Purity
- >95%
- Packaging
- 1g
- Price
- $432
- Updated
- 2021/12/16
AK Scientific
- Product number
- V1853
- Product name
- 2-Methylamino-3-nitro-6-chloropyridine
- Packaging
- 10g
- Price
- $532
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 126420
- Product name
- 6-Chloro-N-methyl-3-nitropyridin-2-amine
- Purity
- >95%
- Packaging
- 5g
- Price
- $1350
- Updated
- 2021/12/16
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2-Methylamino-3-nitro-6-chloropyridine Chemical Properties,Usage,Production
Synthesis
16013-85-7
74-89-5
33742-70-0
General procedure for the synthesis of 2-methylamino-3-nitro-6-chloropyridine (9) from 2,6-dichloro-3-nitropyridine (8) (2.0 g, 10.4 mmol) and monomethylamine: 2,6-dichloro-3-nitropyridine (8) and sodium carbonate (2.75 g, 25.9 mmol) were suspended in ethanol (100 mL). Subsequently, methylamine solution (7.8 mL, 15.6 mmol, 2M) was added to the suspension and the resulting mixture was stirred and reacted for 3 hours at room temperature. Upon completion of the reaction, the yellow reaction solution was concentrated under reduced pressure and the residue was dissolved in ethyl acetate and washed sequentially with sodium bicarbonate solution and saturated brine. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting yellow solid was purified by recrystallization from ethanol to afford the target product 6-chloro-N-methyl-3-nitropyridin-2-amine (9) as a yellow solid (1.6 g, 82% yield). Mass spectrum (MS) m/z (M+H): calculated value=187.6; measured value=187.1. 1H NMR (400MHz, DMSO-d6): δ3.00 (3H, d, J=5.1Hz), 6.77 (1H, d, J=8.1Hz), 8.42 (1H, d, J=8.1Hz), 8.72 (1H, m).
References
[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 16, p. 3052 - 3066
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 4, p. 1260 - 1264
[3] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 3, p. 312 - 317
[4] Patent: US2014/349990, 2014, A1. Location in patent: Paragraph 1013; 1014
[5] Patent: WO2014/191896, 2014, A1. Location in patent: Page/Page column 209
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View Lastest Price from 2-Methylamino-3-nitro-6-chloropyridine manufacturers
Dideu Industries Group Limited
- Product
- 2-Methylamino-3-nitro-6-chloropyridine 33742-70-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 2-Methylamino-3-nitro-6-chloropyridine 33742-70-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
Career Henan Chemical Co
- Product
- 2-Methylamino-3-nitro-6-chloropyridine 33742-70-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kgs
- Release date
- 2020-01-08
33742-70-0, 2-Methylamino-3-nitro-6-chloropyridineRelated Search:
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NITROGEN DIOXIDE
Parathion-methyl
6-chloro-N-ethyl-3-nitropyridin-2-amine