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2-Methylamino-3-nitro-6-chloropyridine

Product Name
2-Methylamino-3-nitro-6-chloropyridine
CAS No.
33742-70-0
Chemical Name
2-Methylamino-3-nitro-6-chloropyridine
Synonyms
2-METHYLAMINO-3-NITRO-6-CHLORO;2-Chloro-5-nitro-6-methylaminopyridine;2-Methylamino-3-nitro-6-chloropyridine;6-Chloro-N-methyl-3-nitro-2-pyridinamine;2-Chloro-6-(methylamino)-5-nitropyridine;6-Chloro-2-(methylamino)-3-nitropyridine;6-Chloro-2-(N-methylamino)-3-nitropyridine;2-PYRIDINAMINE, 6-CHLORO-N-METHYL-3-NITRO-;Pyridine, 6-chloro-2-(methylamino)-3-nitro-;(6-Chloro-3-nitro-pyridin-2-yl)-Methyl-aMine
CBNumber
CB8421232
Molecular Formula
C6H6ClN3O2
Formula Weight
187.58
MOL File
33742-70-0.mol
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2-Methylamino-3-nitro-6-chloropyridine Property

Melting point:
114 °C
Boiling point:
330 °C
Density 
1.489
Flash point:
153 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
-0.67±0.10(Predicted)
Appearance
White to yellow Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C349770
Product name
6-Chloro-2-(N-methylamino)-3-nitropyridine
Packaging
500mg
Price
$165
Updated
2021/12/16
SynQuest Laboratories
Product number
4H55-5-42
Product name
2-Chloro-5-nitro-6-methylaminopyridine
Purity
95.0%
Packaging
1g
Price
$122
Updated
2021/12/16
Matrix Scientific
Product number
126420
Product name
6-Chloro-N-methyl-3-nitropyridin-2-amine
Purity
>95%
Packaging
1g
Price
$432
Updated
2021/12/16
AK Scientific
Product number
V1853
Product name
2-Methylamino-3-nitro-6-chloropyridine
Packaging
10g
Price
$532
Updated
2021/12/16
Matrix Scientific
Product number
126420
Product name
6-Chloro-N-methyl-3-nitropyridin-2-amine
Purity
>95%
Packaging
5g
Price
$1350
Updated
2021/12/16
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2-Methylamino-3-nitro-6-chloropyridine Chemical Properties,Usage,Production

Synthesis

16013-85-7

74-89-5

33742-70-0

General procedure for the synthesis of 2-methylamino-3-nitro-6-chloropyridine (9) from 2,6-dichloro-3-nitropyridine (8) (2.0 g, 10.4 mmol) and monomethylamine: 2,6-dichloro-3-nitropyridine (8) and sodium carbonate (2.75 g, 25.9 mmol) were suspended in ethanol (100 mL). Subsequently, methylamine solution (7.8 mL, 15.6 mmol, 2M) was added to the suspension and the resulting mixture was stirred and reacted for 3 hours at room temperature. Upon completion of the reaction, the yellow reaction solution was concentrated under reduced pressure and the residue was dissolved in ethyl acetate and washed sequentially with sodium bicarbonate solution and saturated brine. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting yellow solid was purified by recrystallization from ethanol to afford the target product 6-chloro-N-methyl-3-nitropyridin-2-amine (9) as a yellow solid (1.6 g, 82% yield). Mass spectrum (MS) m/z (M+H): calculated value=187.6; measured value=187.1. 1H NMR (400MHz, DMSO-d6): δ3.00 (3H, d, J=5.1Hz), 6.77 (1H, d, J=8.1Hz), 8.42 (1H, d, J=8.1Hz), 8.72 (1H, m).

References

[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 16, p. 3052 - 3066
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 4, p. 1260 - 1264
[3] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 3, p. 312 - 317
[4] Patent: US2014/349990, 2014, A1. Location in patent: Paragraph 1013; 1014
[5] Patent: WO2014/191896, 2014, A1. Location in patent: Page/Page column 209

2-Methylamino-3-nitro-6-chloropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methylamino-3-nitro-6-chloropyridine Suppliers

China 67 Germany 1 India 2 Ukraine 1 United Kingdom 1 United States 15 Global 87
UkrOrgSynthesis Ltd.
Tel
--
Fax
--
Email
y.barysheva@ukrorgsynth.com
Country
Ukraine
ProdList
6230
Advantage
38
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View Lastest Price from 2-Methylamino-3-nitro-6-chloropyridine manufacturers

Dideu Industries Group Limited
Product
2-Methylamino-3-nitro-6-chloropyridine 33742-70-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-03
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Methylamino-3-nitro-6-chloropyridine 33742-70-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Career Henan Chemical Co
Product
2-Methylamino-3-nitro-6-chloropyridine 33742-70-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kgs
Release date
2020-01-08

33742-70-0, 2-Methylamino-3-nitro-6-chloropyridineRelated Search:

Methylparaben Bensulfuron methyl Methyl acetate Methyl acrylate Kresoxim-methyl 1-Chloro-3-nitrobenzene 3-Aminopyridine 2-Aminopyridine 4-Dimethylaminopyridine Clopidol Pentachloropyridine Thiophanate-methyl Methyl Difluorochloromethane Methyl bromide NITROGEN DIOXIDE Parathion-methyl 6-chloro-N-ethyl-3-nitropyridin-2-amine

  • 6-Chloro-2-(N-methylamino)-3-nitropyridine
  • (6-Chloro-3-nitro-pyridin-2-yl)-Methyl-aMine
  • Pyridine, 6-chloro-2-(methylamino)-3-nitro-
  • 2-PYRIDINAMINE, 6-CHLORO-N-METHYL-3-NITRO-
  • 2-Methylamino-3-nitro-6-chloropyridine
  • 2-Chloro-6-(methylamino)-5-nitropyridine
  • 6-Chloro-N-methyl-3-nitro-2-pyridinamine
  • 2-METHYLAMINO-3-NITRO-6-CHLORO
  • 6-Chloro-2-(methylamino)-3-nitropyridine
  • 2-Methylamino-3-nitro-6-chloropyridine ISO 9001：2015 REACH
  • 2-Chloro-5-nitro-6-methylaminopyridine
  • 33742-70-0
  • Heterocycle-Pyridine series