N-ACETYLPROCAINAMIDE Property

Melting point:

138-140 °C(lit.)

Boiling point:

500.0±35.0 °C(Predicted)

Density 

1.097±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

soluble1%, clear, colorless to faintly yellow (1N HCl)

form 

Solid

pka

14.54±0.46(Predicted)

color 

White to off-white

Merck 

13,20

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

3249

WGK Germany 

3

RTECS 

AE1974350

HazardClass 

6.1(b)

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

N-ACETYLPROCAINAMIDE Chemical Properties,Usage,Production

Originator

Acecainide ,ZYF Pharm Chemical

Uses

antiprotozoal

Uses

N-acetylprocainamide (NAPA) was used as a model drug in the study of establishing a quantitative approach to predict the renal clearances of basic drugs using N-1-methylnicotinamide (NMN).

Definition

ChEBI: A benzamide obtained via formal condensation of 4-acetamidobenzoic acid and 2-(diethylamino)ethylamine.

Manufacturing Process

1.0 g of p-amino-N-(2-diethylaminoethyl)benzamide is dissolved in chloroform. A few ice cubes are added to the solution. Acetyl chloride is added dropwise with stirring until no more white precipitate forms; the latter is separated by filtering under suction. The precipitate is washed with cold acetone and dried overnight in a vacuum oven at room temperature. The product is dissolved in a minimum amount of hot isopropanol and allowed to precipitate in the cold. The p-acetamido-N-(2-diethylaminoethyl)benzamide hydrochloride, is recrystallized a second time from hot isopropanol, melting point 190°-193°C. The free base is obtained from the hydrochloride by dissolving the latter in water, adjusting the pH to greater than 10 with dilute sodium hydroxide, and adding an equal volume of benzene. After shaking in a separatory funnel, the benzene layer is recovered and evaporated to dryness. So the p-acetamido-N- (2-diethylaminoethyl)benzamide is obtained.

Therapeutic Function

Antiarrhythmic

General Description

The relaxant effects of N-acetylprocainamide on bovine tracheal smooth muscle was studied.