ChemicalBook > CAS DataBase List > TETRAETHYL METHYLENEDIPHOSPHONATE

TETRAETHYL METHYLENEDIPHOSPHONATE

Product Name
TETRAETHYL METHYLENEDIPHOSPHONATE
CAS No.
1660-94-2
Chemical Name
TETRAETHYL METHYLENEDIPHOSPHONATE
Synonyms
1-[diethoxyphosphorylmethyl(ethoxy)phosphoryl]oxyethane;1-5kg;NSC 133889;AURORA KA-1506;enediphosphonate;Tenofovir Impurity 183;BIS(DIETHOXYPHOSPHINYL)METHANE;tetraethyl methylenediphosphate;methylenebis(diethylphosphonate);TETRAETHYL METHYLENEDIPHOSPHONATE
CBNumber
CB8435905
Molecular Formula
C9H22O6P2
Formula Weight
288.21
MOL File
1660-94-2.mol
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TETRAETHYL METHYLENEDIPHOSPHONATE Property

Boiling point:
171-174 °C11 mm Hg(lit.)
Density 
1.16 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.442(lit.)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Sparingly), Methanol (Slightly)
form 
Liquid
Specific Gravity
1.160
color 
Clear yellow to yellow-brown
Water Solubility 
Slightly miscible with water.
BRN 
1813241
InChIKey
STJWVOQLJPNAQL-UHFFFAOYSA-N
CAS DataBase Reference
1660-94-2(CAS DataBase Reference)
EPA Substance Registry System
Phosphonic acid, methylenebis-, tetraethyl ester (1660-94-2)
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Safety

Hazard Codes 
Xi,C
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
SZ9150000
Hazard Note 
Corrosive
TSCA 
Yes
HS Code 
29319090
Toxicity
mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03139,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
359181
Product name
Tetraethyl methylenediphosphonate
Purity
97%
Packaging
5ml
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
359181
Product name
Tetraethyl methylenediphosphonate
Purity
97%
Packaging
25ml
Price
$476
Updated
2024/03/01
Alfa Aesar
Product number
A14532
Product name
Tetraethyl methylenediphosphonate, 98+%
Packaging
5g
Price
$83.4
Updated
2024/03/01
Alfa Aesar
Product number
A14532
Product name
Tetraethyl methylenediphosphonate, 98+%
Packaging
25g
Price
$303
Updated
2024/03/01
Alfa Aesar
Product number
A14532
Product name
Tetraethyl methylenediphosphonate, 98+%
Packaging
100g
Price
$911.65
Updated
2024/03/01
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TETRAETHYL METHYLENEDIPHOSPHONATE Chemical Properties,Usage,Production

Chemical Properties

clear yellow to yellow-brown liquid

Uses

Tetraethyl methylidenebisphosphonate, can be used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters as potent anti-inflammatory agents. It is also an intermediate for the synthesis of new bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity.

Uses

Reactant for synthesis of:

  • Dual substrate-site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
  • Unnatural alpha-amino acid derivatives containing gem-biphosphonates
  • Biphenyl sulfonylamino Me bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption
  • Lycopene via Wittig-Horner reaction
  • Alkylaminoethylbisphosphinic acids to target farnesyl diphosphate synthase
  • Aromatic bisphosphonates for use as inhibitors of geranylgeranyl diphosphate synthase

Precursor for synthesis of dendritic polyglycerol anions used toward L-selectin inhibition

Synthesis Reference(s)

Synthetic Communications, 20, p. 1865, 1990 DOI: 10.1080/00397919008053112
Tetrahedron Letters, 34, p. 1515, 1993 DOI: 10.1016/S0040-4039(00)60333-7

TETRAETHYL METHYLENEDIPHOSPHONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TETRAETHYL METHYLENEDIPHOSPHONATE Suppliers

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View Lastest Price from TETRAETHYL METHYLENEDIPHOSPHONATE manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Tetraethyl methylenediphosphonate 1660-94-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-20
Career Henan Chemical Co
Product
TETRAETHYL METHYLENEDIPHOSPHONATE 1660-94-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kgs
Release date
2019-12-18

1660-94-2, TETRAETHYL METHYLENEDIPHOSPHONATERelated Search:

Diethyl iminodiacetate METHYL TETRAHYDROPYRAN-3-CARBOXYLATE TETRAETHYLENE GLYCOL DI-P-TOSYLATE Tetraethylene glycol dimethacrylate Tetrabutylammonium tribromide Tetraethyl orthocarbonate TERT-BUTYL DIAZOACETATE Tetrabutylammonium hexafluorophosphate Titanium tetraisopropanolate Titanium ethoxide Glycidol Tetrabutylammonium Difluorotriphenylsilicate 9-[(2S)-2-(diethoxyphosphorylmethoxy)propyl]purin-6-amine INDEX NAME NOT YET ASSIGNED Ethyl L-alaninate hydrochloride ChloroMethyl Methyl Carbonate Tenofovir Impurity 37 Tenofovir impurity E

  • methylenedi-phosphonicacitetraethylester
  • METHYLENEDIPHOSPHONIC ACID TETRAETHYL ESTER
  • AURORA KA-1506
  • BIS(DIETHOXYPHOSPHINYL)METHANE
  • TETRAETHYL(METHYLENE)BISPHOSPHONATE
  • TETRAETHYL METHYLENEDIPHOSPHONATE
  • Tetraethyl methylenediphosphonate, 98+%
  • methanediyl-bis-phosphonic acid tetraethyl ester
  • Tetraethyl(methylene)bisphosphonate, 98 %
  • Tetraethyl methylidenediphosphonate
  • 1-5kg
  • Tetraethyl methylenediphosphonate,97%
  • Tetraethyl methylenediphosphonatedisc 6/01
  • Tetraethyl methanediylbis(phosphonate)
  • Tetraethyl Methylenediphosphonate, 97% 25ML
  • Tetraethyl Methylenediphosphonate, 97% 5ML
  • tetraethyl methylenediphosphate
  • Bis(diethoxyphosphinyl)methane, Methylenediphosphonic acid tetraethylester
  • [α,β-Methylene]diphosphoric acid tetraethyl
  • Methylenebis(phosphonic acid diethyl)
  • Methylenebisphosphonic acid tetraethyl
  • Methylenedi(phosphonic acid diethyl) ester
  • NSC 133889
  • methylenebis(diethylphosphonate)
  • methylenebis-phosphonicacitetraethylester
  • Tetraethyl methylenediphosphonate 97%
  • Tetraethylemethylenediphosphonate
  • 1-[diethoxyphosphorylmethyl(ethoxy)phosphoryl]oxyethane
  • enediphosphonate
  • Phosphonic acid, P,P'-methylenebis-, P,P,P',P'-tetraethyl ester
  • Tenofovir Impurity 183
  • diethyl [(diethoxyphosphoryl)methyl]phosphonate
  • 1660-94-2
  • CH2POOCH2CH322
  • C9H22O6P2
  • Horner-Wadsworth-Emmons Reagents
  • Synthetic Reagents
  • Olefination
  • C-C Bond Formation
  • Naphthyridine,Quinoline
  • Other
  • OLED