TETRAETHYL METHYLENEDIPHOSPHONATE

Product Name: TETRAETHYL METHYLENEDIPHOSPHONATE
CAS No.: 1660-94-2
Chemical Name: TETRAETHYL METHYLENEDIPHOSPHONATE
Synonyms: 1-[diethoxyphosphorylmethyl(ethoxy)phosphoryl]oxyethane;1-5kg;NSC 133889;AURORA KA-1506;enediphosphonate;Tenofovir Impurity 183;BIS(DIETHOXYPHOSPHINYL)METHANE;tetraethyl methylenediphosphate;methylenebis(diethylphosphonate);TETRAETHYL METHYLENEDIPHOSPHONATE
CBNumber: CB8435905
Molecular Formula: C9H22O6P2
Formula Weight: 288.21
MOL File: 1660-94-2.mol

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TETRAETHYL METHYLENEDIPHOSPHONATE Property

Boiling point:: 171-174 °C11 mm Hg(lit.)
Density: 1.16 g/mL at 25 °C(lit.)
refractive index: n20/D 1.442(lit.)
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Liquid
Specific Gravity: 1.160
color: Clear yellow to yellow-brown
Water Solubility: Slightly miscible with water.
BRN: 1813241
InChIKey: STJWVOQLJPNAQL-UHFFFAOYSA-N
CAS DataBase Reference: 1660-94-2(CAS DataBase Reference)
EPA Substance Registry System: Phosphonic acid, methylenebis-, tetraethyl ester (1660-94-2)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: SZ9150000
Hazard Note: Corrosive
TSCA: Yes
HS Code: 29319090
Toxicity: mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03139,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 359181
Product name: Tetraethyl methylenediphosphonate
Purity: 97%
Packaging: 5ml
Price: $113
Updated: 2024/03/01

Sigma-Aldrich

Product number: 359181
Product name: Tetraethyl methylenediphosphonate
Purity: 97%
Packaging: 25ml
Price: $476
Updated: 2024/03/01

Alfa Aesar

Product number: A14532
Product name: Tetraethyl methylenediphosphonate, 98+%
Packaging: 5g
Price: $83.4
Updated: 2024/03/01

Alfa Aesar

Product number: A14532
Product name: Tetraethyl methylenediphosphonate, 98+%
Packaging: 25g
Price: $303
Updated: 2024/03/01

Alfa Aesar

Product number: A14532
Product name: Tetraethyl methylenediphosphonate, 98+%
Packaging: 100g
Price: $911.65
Updated: 2024/03/01

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TETRAETHYL METHYLENEDIPHOSPHONATE Chemical Properties,Usage,Production

Chemical Properties

clear yellow to yellow-brown liquid

Uses

Tetraethyl methylidenebisphosphonate, can be used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters as potent anti-inflammatory agents. It is also an intermediate for the synthesis of new bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity.

Uses

Reactant for synthesis of:

Dual substrate-site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
Unnatural alpha-amino acid derivatives containing gem-biphosphonates
Biphenyl sulfonylamino Me bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption
Lycopene via Wittig-Horner reaction
Alkylaminoethylbisphosphinic acids to target farnesyl diphosphate synthase
Aromatic bisphosphonates for use as inhibitors of geranylgeranyl diphosphate synthase

Precursor for synthesis of dendritic polyglycerol anions used toward L-selectin inhibition

Synthesis Reference(s)

Synthetic Communications, 20, p. 1865, 1990 DOI: 10.1080/00397919008053112
Tetrahedron Letters, 34, p. 1515, 1993 DOI: 10.1016/S0040-4039(00)60333-7

TETRAETHYL METHYLENEDIPHOSPHONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TETRAETHYL METHYLENEDIPHOSPHONATE Suppliers

Austria 1 Belgium 3 Canada 1 CHINA 128 France 3 Germany 5 India 9 Japan 4 South Korea 1 Switzerland 3 United Kingdom 13 United States 26 Global 197

Alfa Aesar

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Advantage: 58

ALTAIR ALCHEMY Laboratories

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Clarity Research Laboratory

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Reax Chemicals

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M/S CLARITY RESEARCH LABORATORY

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A.J Chemicals

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View Lastest Price from TETRAETHYL METHYLENEDIPHOSPHONATE manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: Tetraethyl methylenediphosphonate 1660-94-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-20

Career Henan Chemical Co

Product: TETRAETHYL METHYLENEDIPHOSPHONATE 1660-94-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kgs
Release date: 2019-12-18

1660-94-2, TETRAETHYL METHYLENEDIPHOSPHONATERelated Search:

Diethyl iminodiacetate METHYL TETRAHYDROPYRAN-3-CARBOXYLATE TETRAETHYLENE GLYCOL DI-P-TOSYLATE Tetraethylene glycol dimethacrylate Tetrabutylammonium tribromide Tetraethyl orthocarbonate TERT-BUTYL DIAZOACETATE Tetrabutylammonium hexafluorophosphate Titanium tetraisopropanolate Titanium ethoxide Glycidol Tetrabutylammonium Difluorotriphenylsilicate 9-[(2S)-2-(diethoxyphosphorylmethoxy)propyl]purin-6-amine INDEX NAME NOT YET ASSIGNED Ethyl L-alaninate hydrochloride ChloroMethyl Methyl Carbonate Tenofovir Impurity 37 Tenofovir impurity E

methylenedi-phosphonicacitetraethylester

METHYLENEDIPHOSPHONIC ACID TETRAETHYL ESTER

AURORA KA-1506

BIS(DIETHOXYPHOSPHINYL)METHANE

TETRAETHYL(METHYLENE)BISPHOSPHONATE

TETRAETHYL METHYLENEDIPHOSPHONATE

Tetraethyl methylenediphosphonate, 98+%

methanediyl-bis-phosphonic acid tetraethyl ester

Tetraethyl(methylene)bisphosphonate, 98 %

Tetraethyl methylidenediphosphonate

1-5kg

Tetraethyl methylenediphosphonate,97%

Tetraethyl methylenediphosphonatedisc 6/01

Tetraethyl methanediylbis(phosphonate)

Tetraethyl Methylenediphosphonate, 97% 25ML

Tetraethyl Methylenediphosphonate, 97% 5ML

tetraethyl methylenediphosphate

Bis(diethoxyphosphinyl)methane, Methylenediphosphonic acid tetraethylester

[α,β-Methylene]diphosphoric acid tetraethyl

Methylenebis(phosphonic acid diethyl)

Methylenebisphosphonic acid tetraethyl

Methylenedi(phosphonic acid diethyl) ester

NSC 133889

methylenebis(diethylphosphonate)

methylenebis-phosphonicacitetraethylester

Tetraethyl methylenediphosphonate 97%

Tetraethylemethylenediphosphonate

1-[diethoxyphosphorylmethyl(ethoxy)phosphoryl]oxyethane

enediphosphonate

Phosphonic acid, P,P'-methylenebis-, P,P,P',P'-tetraethyl ester

Tenofovir Impurity 183

diethyl [(diethoxyphosphoryl)methyl]phosphonate

1660-94-2

CH2POOCH2CH322

C9H22O6P2

Horner-Wadsworth-Emmons Reagents

Synthetic Reagents

Olefination

C-C Bond Formation

Naphthyridine,Quinoline

Other

OLED