Isoflurane

ChemicalBook > CAS DataBase List > Isoflurane

Product Name: Isoflurane
CAS No.: 26675-46-7
Chemical Name: Isoflurane
Synonyms: Forane;Isoflurane266;2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane;1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER;(2R)-2-chloro-2-(difluoroMethoxy)-1,1,1-trifluoroethane;IsofL;Forene;Aerrane;Terrell;Isourane
CBNumber: CB8437691
Molecular Formula: C3H2ClF5O
Formula Weight: 184.49
MOL File: 26675-46-7.mol

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Isoflurane Property

Melting point:: 48.5°C
Boiling point:: 48.5 °C
Density: 1.510 g/mL at 25 °C
vapor pressure: 238 mmHg ( 20 °C)
refractive index: 1.3002
Flash point:: 48-49°C
storage temp.: 2-8°C
solubility: Practically insoluble in water, miscible with ethanol and trichloroethylene.
Specific Gravity: approximate 1.50
color: Colorless to Almost colorless
Water Solubility: Soluble in chloroform and ethyl acetate. Not miscible or difficult to mix in water.
Merck: 14,5175
BRN: 1852087
Stability:: Stable.
InChIKey: PIWKPBJCKXDKJR-UHFFFAOYSA-N
CAS DataBase Reference: 26675-46-7(CAS DataBase Reference)
NIST Chemistry Reference: 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether(26675-46-7)
EPA Substance Registry System: Isoflurane (26675-46-7)

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Safety

Hazard Codes: F,T,Xn
Risk Statements: 36/37/38-67-48/20
Safety Statements: 26-36/37/39-24/25
RIDADR: UN 3334
WGK Germany: 3
RTECS: KN6799000
Hazard Note: Flammable/Toxic
HS Code: 2909191800
Hazardous Substances Data: 26675-46-7(Hazardous Substances Data)
Toxicity: An isomer of enflurane with similar anesthetic properties. Isoflurane has less effect on myocardial function, leaving the cardiovascular system normally responsive to epinephrine or hypercarbia, and it does not cause a marked increase in seizure susceptibility. It was not widely used because of reports that it caused increases in liver neoplasms in mice, but this observation has been challenged and the compound reintroduced.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000858
Product name: Isoflurane
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 2EA
Price: $161
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2874
Product name: Isoflurane
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 1.2ML
Price: $201
Updated: 2024/03/01

Sigma-Aldrich

Product number: 792632
Product name: Isoflurane
Packaging: 1g
Price: $120
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1349003
Product name: Isoflurane
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 1ml
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: C2485
Product name: 1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether
Purity: >98.0%(GC)
Packaging: 5g
Price: $50
Updated: 2024/03/01

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Isoflurane Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Originator

Forane,Ohio Medical,US,1980

Uses

Isoflurane is a volatile anesthetic agent mainly used to study its interaction with the biological system.

Uses

Isoflurane is a halogenated ether used for inhalational anesthesia. Recent studies suggest that there might be a relationship between administration of isoflurane and postoperative cognitive dysfunct ion (POCD).

Uses

Solvent and dispersant for fluorinated materials.

Definition

ChEBI: Isoflurane is an organofluorine compound. It has a role as an inhalation anaesthetic. It is functionally related to a methoxyethane.

Manufacturing Process

A 1-liter 3-necked stainless steel flask was fitted with a copper "Dry Ice" cold finger condenser, a stainless steel stirring shaft and gland and a copper gas inlet tube. To the flask there was then added 50 g (0.23 mol) of CF3CHClOCHCl2 and 1.5 g of SbCl5 · HF gas was then slowly bubbled through the stirred mixture which was maintained at 0°C. The reaction was run until 0.35 mol of HCl was collected, as indicated by the titration of the effluent gas which was dissolved in water. Following the fluorination 26 g of material were recovered and determined to be 90% pure by vapor phase chromatography. Fractional distillation using a 30 x 0.5 cm column packed with glass helices gave the pure product, BP 48°C to 48.5°C.

brand name

Forane (Baxter Healthcare).

Therapeutic Function

Inhalation anesthetic

Biological Functions

Isoflurane (Forane) is a structural isomer of enflurane and produces similar pharmacological properties: some analgesia, some neuromuscular blockade, and depressed respiration. In contrast, however, isoflurane is considered a particularly safe anesthetic in patients with ischemic heart disease, since cardiac output is maintained, the coronary arteries are dilated, and the myocardium does not appear to be sensitized to the effects of catecholamines. Also, blood pressure falls as a result of vasodilation, which preserves tissue blood flow. Isoflurane causes transient and mild tachycardia by direct sympathetic stimulation; this is particularly important in the management of patients with myocardial ischemia.
Unlike enflurane, isoflurane does not produce a seizurelike EEG pattern. Furthermore, the metabolic transformation of isoflurane is only one-tenth that of enflurane, so fluoride production is quite low. Among the halogenated hydrocarbons, isoflurane is one of the most popular, since it preserves cardiovascular stability and causes a low incidence of untoward effects.

General Description

Isoflurane is a volatile liquid (bp＝48.5°C) with an MAC of1.15, a blood:gas partition coefficient of 1.43 and high solubilityin fat. Isoflurane is a structural isomer of enflurane. Itis a known respiratory irritant, but less so than desflurane.Approximately 0.2% of the administered drug undergoesmetabolism, the rest is exhaled unchanged. The metabolismof isoflurane yields low levels of the nephrotoxic fluoride ionas well as a potentially hepatotoxic trifluoroacetylating compound). The relatively low concentrations ofthese compounds have resulted in very low risks of hepatotoxicityand nephrotoxicity. There have been no reports ofseizures caused by isoflurane and only transient increases inheart rate have been reported.

Biochem/physiol Actions

Isoflurane is a tandem pore potassium channel activator. It is also a very widely used anesthetic for animal research and for in vitro studies on anesthesia mechanisms.

Clinical Use

Isoflurane was introduced in the United States in 1981 and is a potent anesthetic agent with many similarities to its isomer enflurane (potent, nonflammable, and intermediate blood solubility). It does produce significantly fewer cardiovascular effects than enflurane, however, and it can be used safely with epinephrine without as great a concern for arrhythmia production. Isoflurane has a more pungent odor than halothane and, thus, can cause irritation to the throat and respiratory tract, triggering coughing and laryngospasm. To overcome this problem, it often is supplemented with intravenous agents. Less than 0.2% of an administered dose is metabolized, mostly to fluoride and trifluoroacetic acid. Some minimal potential for hepatotoxicity is associated with a trifluoroacetyl halide metabolite.

Synthesis

Isoflurane is prepared by chlorination of 2,2,2-trifluoroethoxydifluoromethane, itself obtained by alkylation of trifluoroethanol with difluorochloromethane , :

Veterinary Drugs and Treatments

Isoflurane is an inhalant anesthetic that has some distinct advantages over either halothane or methoxyflurane due to its lessened myocardial depressant and catecholamine sensitizing effects, and the ability to use it safely in patients with either hepatic or renal disease. Isoflurane’s higher cost than either methoxyflurane or halothane is a disadvantage.
Horses may recover more rapidly than with halothane, but be more susceptible to anesthetic associated- myopathy.

Isoflurane Preparation Products And Raw materials

Raw materials

2,2,2-TRIFLUOROETHYL METHYL ETHER HYDROGEN FLUORIDE GAS 2,2,2-Trifluoroethanol BIS(CHLOROMETHYL)ETHER ANTIMONY(V) CHLORIDE

Preparation Products

Desflurane

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View Lastest Price from Isoflurane manufacturers

Wuhan Boyuan Import & Export Co., LTD

Product: Isoflurane 26675-46-7
Price: US $20.00-10.00/kg
Min. Order: 1kg
Purity: 99.60%
Supply Ability: 50tons
Release date: 2023-12-11

Hebei Ningnan Trade Co. LTD

Product: Isoflurane 26675-46-7
Price: US $10.00/G
Min. Order: 1G
Purity: 99.99%
Supply Ability: 20MT
Release date: 2022-10-24

Jinan Shengqi pharmaceutical Co,Ltd

Product: Isoflurane 26675-46-7
Price: US $0.00/KG
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Purity: 99
Supply Ability: 10MT
Release date: 2019-03-21

26675-46-7, IsofluraneRelated Search:

Epichlorohydrin 1,1,2,2-Tetrachloroethane 4-(Trifluoromethoxy)aniline 5-METHYLHEXANOIC ACID Dichloromethyl 2,2,2-trifluoroethyl ether TRIS(2,2,2-TRIFLUOROETHYL)ORTHOFORMATE C8E3 CHLOROETHANE Ethylbenzene (Trifluoromethoxy)benzene 4-Methoxybenzylchloride compound 485 (2,2,2-Trifluoroethoxy)difluoroacetic Acid 1-Chloro-2,2,2-trifluoroethyl chlorodifluoroMethyl ether Ethane, 2-(chlorofluoromethoxy)-1,1,1-trifluoro- Butanoic acid, 4-(2,2,2-trifluoroethoxy)- DIFLUOROMETHYL 2,2,2-TRIFLUOROETHYL ETHER Isoquinoline

Isoflurane266

ether,1-chloro-2,2,2-trifluoroethyldifluoromethyl

Forane

Forene

r-e235dal

1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether 99%

1-Chloro-2,2,2-trifluoroethyldifluoromethylether99%

2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethan

2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane

Aerrane

chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane

chloro-2,2,2-trifluorodifluoromethylether

Compd 469

Compound 469

Ethane, 1-chloro-1-(difluoromethoxy)-2,2,2-trifluoro-

Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-

Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl

Difluoromethyl 1-chloro-2,2,2-trifluoroethyl ether (Isoflurane)

Isourane

IsofL

Difluoromethyl 1-chloro-2,2,2-trifluoroethyl ether

Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro- (9CI)

HCFE 235da2

R-E 235da1

ISOFLUORENE

1-CHLORO-2，2，2-trifiuoroethyl dinuoromethyl ether

Isourane (1 mL)

Isoflurane (1 mL)

(2R)-2-chloro-2-(difluoroMethoxy)-1,1,1-trifluoroethane

2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane Isoflurane

1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER

ISOFLURANE

1-Chloro-2,2,2-trifluoroethyl ether

1-Chloro-2,2,2-trifluoroethyldrfluoromethylether

Isoflurane CRS

Isoflurane RS

lsoflurane

HSDB 8057

HSDB8057

HSDB-8057

Terrell

Isoflurane (1349003)

1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether, 98+%

26675-46-7

C3H2CIF5O

CF3CHClOCHF2