(2-Hydroxypropyl)-γ-cyclodextrin

Product Name: (2-Hydroxypropyl)-γ-cyclodextrin
CAS No.: 128446-34-4
Chemical Name: (2-Hydroxypropyl)-γ-cyclodextrin
Synonyms: HPGCD;HP-gamma-CD;CAVASOL(R)W8;Cavasol? W8 HP;Calcium Dobesilate Capsules;2-FLUORO-4-METHYL-1-NITROBENZENE;HydroxypropyI Gamma Cyclodextrin;(2-Hydroxypropyl)-γ-cyclodextrin,HGC;g-Cyclodextrin, 2-hydroxypropylethers;(2-Hydroxyapropyl)-gamma-cyclodextrin
CBNumber: CB8449476
Molecular Formula: C48H80-nO40.(C3H7O)n
Formula Weight: 0
MOL File: 128446-34-4.mol

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(2-Hydroxypropyl)-γ-cyclodextrin Property

Melting point:: 52-55 °C(lit.)
Boiling point:: 97-98 °C3 mm Hg(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: H2O: soluble450mg/mL
form: Solid powder
color: white
PH: 6-9 (2% in H2O)
optical activity: [α]20/D +145°, c = 1 in H2O
InChIKey: WZMOWQCNPFDWPA-UHFFFAOYSA-N
CAS DataBase Reference: 128446-34-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HS Code: 2940000080

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H125
Product name: (2-Hydroxypropyl)-γ-cyclodextrin
Purity: solid
Packaging: 5G
Price: $138
Updated: 2024/03/01

Sigma-Aldrich

Product number: H125
Product name: (2-Hydroxypropyl)-γ-cyclodextrin
Purity: solid
Packaging: 100g
Price: $1050
Updated: 2024/03/01

Sigma-Aldrich

Product number: 390704
Product name: (2-Hydroxypropyl)-γ-cyclodextrin
Purity: extent of labeling: 0.6 molar substitution
Packaging: 5g
Price: $78.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 390704
Product name: (2-Hydroxypropyl)-γ-cyclodextrin
Purity: extent of labeling: 0.6 molar substitution
Packaging: 25g
Price: $168
Updated: 2024/03/01

Sigma-Aldrich

Product number: 779229
Product name: (2-Hydroxypropyl)-γ-cyclodextrin
Purity: Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, ≥98.0% (HPLC)
Packaging: 100g
Price: $490
Updated: 2024/03/01

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(2-Hydroxypropyl)-γ-cyclodextrin Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

For R&D use

General Description

(2-Hydroxypropyl)-γ-cyclodextrin belongs to the class of cyclodextrin derivatives, which exhibit a greater extent of solubility in water compared to their parent compounds. It is widely used in parenteral formulations and solid dosage forms to aid in the improvement of their stability, dissolution, bioavailability, etc.

Biological Activity

(2-Hydroxypropyl)-γ-cyclodextrin (HPγCD) is a water-soluble alkylated cyclodextrin derivative. It has pharmaceutical potential as it may aid in enhancing the solubility of drugs for oral dosage preparations or formulations. It solubilizes macromolecules, such as cholesterol. It is like β cyclodextrin but solubilizes larger molecules. It favors lysosomes distribution across the cytoplasm and can modulate lysosomal dynamics and participates in lysosomal homeostasis. HPγCD treatment promotes a wide distribution of lysosomes across the cytoplasm in NPC1 patient-derived fibroblasts. In contrast, lysosomes are clustered near the cell center in untreated cells, raising the possibility that HPγCD has the potential to modulate lysosomal dynamics and functions[1]. In the Niemann pick disease model, HPγCD reduces cholesterol accumulation. Industrially produced HPγCD, which is used as a complexing agent in new ophthalmic formulations, is not a single compound but a heterogeneous, complex mixture of homologues and isomers substituted by a variable number of 2-hydroxy-propyl groups at different positions of the sugar moieties[2].

References

[1] Ashutosh Singhal. “2-Hydroxypropyl-gamma-cyclodextrin overcomes NPC1 deficiency by enhancing lysosome-ER association and autophagy.” Scientific Reports (2020): 8663.
[2] W Blum . "Determination of 2-hydroxypropyl-γ-cyclodextrin in plasma of cynomolgus monkeys after oral administration by gas chromatography–mass spectrometry.” Journal of Chromatography B: Biomedical Sciences and Applications 720 1 (1998): Pages 171-178.

(2-Hydroxypropyl)-γ-cyclodextrin Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-Hydroxypropyl)-γ-cyclodextrin Suppliers

China 152 Germany 2 India 3 Japan 2 Switzerland 2 United Kingdom 9 United States 19 Global 189

Carbosynth

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Carbosynth Limited

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Fulcrum Scientific Ltd.

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View Lastest Price from (2-Hydroxypropyl)-γ-cyclodextrin manufacturers

Watson Biotechnology Co.,Ltd

Product: (2-Hydroxypropyl)-gamma-cyclodextrin 128446-34-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20MT
Release date: 2024-08-14

Wuhan Fortuna Chemical Co.,Ltd

Product: (2-Hydroxypropyl)-γ-cyclodextrin 128446-34-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-08-10

Shanghai UCHEM Inc.

Product: (2-Hydroxypropyl)-gamma-cyclodextrin 128446-34-4
Price: US $62.00-196.00/g
Min. Order: 25g
Purity: 0.98
Supply Ability: 25kg
Release date: 2023-10-30

128446-34-4, (2-Hydroxypropyl)-γ-cyclodextrinRelated Search:

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(2-Hydroxypropyl)-gamma-cyclodextrin produced by Wacker Chemie AG, Burghausen, Germany

(2-Hydroxypropyl)-gamma-cyclodextrin Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, >=98.0% (HPLC)

(2-Hydroxypropyl)-gaMMa-cyclodextrin extent of labeling: 0.6 Molar substitution

HYDROXYPROPYL-GAMMA-CYCLODEXTRIN (HGC) 4 5% W/V SOLUTION IN H2O

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(2-Hydroxypropyl)-γ-cyclodextrin (Technical Grade)

Hydroxypropyl-Gamma-Cyclodextrin with good quality and stable supply

(2-Hydroxypropyl)-gamma-cyclodextrin,average Mw ~1，589

HydroxypropyI Gamma Cyclodextrin

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