Boc-1-amino-3,6-dioxa-8-octanediamine
- Product Name
- Boc-1-amino-3,6-dioxa-8-octanediamine
- CAS No.
- 153086-78-3
- Chemical Name
- Boc-1-amino-3,6-dioxa-8-octanediamine
- Synonyms
- BOC-NH-PEG2-NH2;NHBoc-PEG3-NH2;N-BOC-2,2'-(ETHYLENEDIOXY)DIETHYLAMINE;{2-[2-(2-AMino-ethoxy)-ethoxy]-ethyl}-carbaMic acid tert-butyl ester;BOC-DOOA;NH2-PEG2-NHBOC;NHBoc-PEG2-amine;PROTAC Linker 13;BOC-N-AMIDO-PEG2-NH2;Boc-NH-PEG2-CH2CH2NH2
- CBNumber
- CB8456887
- Molecular Formula
- C11H24N2O4
- Formula Weight
- 248.32
- MOL File
- 153086-78-3.mol
Boc-1-amino-3,6-dioxa-8-octanediamine Property
- Boiling point:
- 365.2±27.0 °C(Predicted)
- Density
- 1.046 g/mL at 20 °C
- refractive index
- 1.4570 to 1.4610
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- clear liquid
- pka
- 12.23±0.46(Predicted)
- color
- Colorless to Light yellow to Light orange
- InChI
- InChI=1S/C11H24N2O4/c1-11(2,3)17-10(14)13-5-7-16-9-8-15-6-4-12/h4-9,12H2,1-3H3,(H,13,14)
- InChIKey
- OCUICOFGFQENAS-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NCCOCCOCCN
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 89761
- Product name
- N-Boc- 2,2′-(ethylenedioxy)diethylamine
- Purity
- ≥95.0% (NT)
- Packaging
- 1g
- Price
- $228
- Updated
- 2025/07/31
- Product number
- 89761
- Product name
- N-Boc- 2,2′-(ethylenedioxy)diethylamine
- Purity
- ≥95.0% (NT)
- Packaging
- 5G
- Price
- $611.8
- Updated
- 2025/07/31
- Product number
- B5141
- Product name
- N-(tert-Butoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 200mg
- Price
- $75
- Updated
- 2025/07/31
- Product number
- B5141
- Product name
- N-(tert-Butoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine
- Purity
- >97.0%(HPLC)
- Packaging
- 1g
- Price
- $276
- Updated
- 2025/07/31
- Product number
- 262064
- Product name
- Boc-1-amino-3,6-dioxa-8-octanediamine
- Packaging
- 500mg
- Price
- $340
- Updated
- 2021/12/16
Boc-1-amino-3,6-dioxa-8-octanediamine Chemical Properties,Usage,Production
Description
t-Boc-N-Amido-PEG2-amine is a PEG linker containing an amino group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical Properties
Light yellow oil
Uses
Linker reagent for the prep. of a broad variety of linked tags, monomers for polymerisation, ionophores etc., e.g. biotinylation reagents.
reaction suitability
reagent type: cross-linking reagent
Synthesis
929-59-9
24424-99-5
153086-78-3
General procedure: A dichloromethane solution (10 mL/mmol) of 1,8-diamino-3,6-dioxaoctane (1 eq.) was treated with di-tert-butyl dicarbonate (0.15 eq.) at 0 °C, kept at 0 °C for 5 hours, and then the reaction was continued at room temperature for 18 hours. Upon completion of the reaction, the organic phase was washed with water until all unreacted 1,8-diamino-3,6-dioxaoctane was removed by extraction. The organic phase was dried over anhydrous magnesium sulfate and recovered quantitatively to give the Boc-protected product tert-butyl 2-(2-(2-aminoethoxy)ethoxy)ethylcarbamate, which was concentrated under vacuum. The product characterization data were as follows:11a: 1H NMR (300 MHz, CDCl3): δ 1.45 (s, 9H), 1.80 (br m, 2H, NH2), 3.25 (m, 2H), 3.38 (m, 2H), 3.50-3.70 (m, 8H), 5.10 (br s, 1H, NHCO2).11b: 1H NMR ( 300 MHz, CDCl3): δ 1.42 (s, 9H), 1.75 (br m, 2H, NH2), 2.84 (t, 2H, J = 5.3 Hz), 3.29 (m, 2H), 3.51 (m, 4H), 3.58 (sharp m, 8H), 5.30 (br s, 1H, NHCO2).
IC 50
PEGs
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 15, p. 4208 - 4212
[2] Tetrahedron, 2012, vol. 68, # 52, p. 10818 - 10826
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 17, p. 2678 - 2685
[4] Journal of the American Chemical Society, 2013, vol. 135, # 34, p. 12684 - 12689
[5] Tetrahedron, 2017, vol. 73, # 33, p. 4972 - 4978
Boc-1-amino-3,6-dioxa-8-octanediamine Preparation Products And Raw materials
Raw materials
Preparation Products
Boc-1-amino-3,6-dioxa-8-octanediamine Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6581
- Advantage
- 61
- Tel
- --
- Fax
- --
- cms.marketing@cms-chemicals.com
- Country
- United Kingdom
- ProdList
- 3708
- Advantage
- 60
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
View Lastest Price from Boc-1-amino-3,6-dioxa-8-octanediamine manufacturers
- Product
- BocNH-PEG2-CH2CH2NH2 153086-78-3
- Price
- US $8824.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 300kg
- Release date
- 2025-11-15
- Product
- tert-butyl (2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamate 153086-78-3
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2025-09-12
- Product
- tert-Butyl [2-[2-(2-aminoethoxy)ethoxy]ethyl]carbamate 153086-78-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-27