2-Methyl-6-nitroaniline
Uses- Product Name
- 2-Methyl-6-nitroaniline
- CAS No.
- 570-24-1
- Chemical Name
- 2-Methyl-6-nitroaniline
- Synonyms
- 2-AMINO-3-NITROTOLUENE;6-NITRO-O-TOLUIDINE;2-Amino-3-nitro toulene;NSC 286;NSC 52218;-6-nitroaniL;6-Nitro-o-tol;LABOTEST-BB LTBB000621;3-NITRO-2-AMINOTOLUENE;2-NITRO-6-METHYLANILINE
- CBNumber
- CB8457596
- Molecular Formula
- C7H8N2O2
- Formula Weight
- 152.15
- MOL File
- 570-24-1.mol
2-Methyl-6-nitroaniline Property
- Melting point:
- 93-96 °C (lit.)
- Boiling point:
- 124 °C / 1mmHg
- Density
- 1.19 g/cm3
- refractive index
- 1.6276 (estimate)
- Flash point:
- 110 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- <1mg/l
- pka
- -0.44±0.25(Predicted)
- form
- Crystalline Powder
- color
- Brownish
- Water Solubility
- <0.1 g/100 mL at 23 ºC
- BRN
- 1868029
- CAS DataBase Reference
- 570-24-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Methyl-6-nitroaniline(570-24-1)
- EPA Substance Registry System
- 2-Methyl-6-nitroaniline (570-24-1)
Safety
- Hazard Codes
- T,N,Xi
- Risk Statements
- 23/24/25-33-51/53
- Safety Statements
- 28-36/37-45-61-28A
- RIDADR
- UN 2660 6.1/PG 3
- WGK Germany
- 3
- F
- 10
- Hazard Note
- Toxic
- HazardClass
- 6.1
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 29214300
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P314Get medical advice/attention if you feel unwell.
N-Bromosuccinimide Price
- Product number
- M59408
- Product name
- 2-Methyl-6-nitroaniline
- Purity
- 99%
- Packaging
- 10g
- Price
- $77.9
- Updated
- 2025/07/31
- Product number
- M59408
- Product name
- 2-Methyl-6-nitroaniline
- Purity
- 99%
- Packaging
- 100g
- Price
- $674
- Updated
- 2023/06/20
- Product number
- N0467
- Product name
- 2-Methyl-6-nitroaniline
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $129
- Updated
- 2025/07/31
- Product number
- N0467
- Product name
- 2-Methyl-6-nitroaniline
- Purity
- >99.0%(GC)
- Packaging
- 250g
- Price
- $455
- Updated
- 2025/07/31
- Product number
- M323560
- Product name
- 2-Methyl-6-nitroaniline
- Packaging
- 250g
- Price
- $525
- Updated
- 2021/12/16
2-Methyl-6-nitroaniline Chemical Properties,Usage,Production
Uses
2-Methyl-6-nitroaniline is a compound useful in organic synthesis. Dyes and metabolites, Environmental Testing.
Chemical Properties
Redish-Brown Solid
Uses
2-Methyl-6-nitroaniline (cas# 570-24-1) is a compound useful in organic synthesis. Dyes and metabolites, Environmental Testing
General Description
Orange-yellow prisms or brown granular powder.
Air & Water Reactions
2-Methyl-6-nitroaniline is sensitive to prolonged exposure to air. Insoluble in water.
Reactivity Profile
2-Methyl-6-nitroaniline is incompatible with acids, acid chlorides, acid anhydrides, chloroformates, and strong oxidizers.
Fire Hazard
Flash point data for 2-Methyl-6-nitroaniline are not available, but 2-Methyl-6-nitroaniline is probably combustible.
Synthesis
120-66-1
570-24-1
The general procedure for the synthesis of 2-methyl-6-nitroaniline from 2-methylacetanilide was carried out as follows: the modified Howard method [27] was used. Toluidine (1a or 1b; 53.5 mL, 0.5 mol) was slowly added to acetic anhydride (325 mL) in batches while maintaining constant stirring. The reaction solution was cooled to 12-13 °C in an ice-salt bath. Subsequently, 70% nitric acid (63 mL) was slowly added dropwise to the reaction mixture at a rate that maintained the temperature at 10-12 °C with constant stirring. The dropwise addition process took 2.5 h to complete, after which the solution was poured into 1.5 L of ice water. The resulting acetamide (3a, or a mixture of 3b and 3c) precipitate (as a cream-colored solid) was collected on a Brinell's funnel, washed with four 250 mL portions of ice water, and partially dried by suction. The wetted acetamide (3a, or a mixture of 3b and 3c) was mixed with 70% sulfuric acid (100 mL) and stirred at reflux for 3 hours. The acetamide 3b was separated from the reaction mixture by steam distillation to give the hydrolysis product of 2-methyl-6-nitroaniline (4b). After the distiller was cooled, the isolated bright orange needle-like crystals 4b were collected on a Brinell funnel and dried in a vacuum desiccator. If acetamide 3a was hydrolyzed, the warm reaction mixture was diluted with 350 mL of water and alkalized with 10% aqueous sodium hydroxide. After cooling to room temperature, 4-methyl-2-nitroaniline (4a) precipitated as a brown powder, which was separated by vacuum filtration, washed with three parts of 200 mL of water, and dried in a vacuum desiccator. The yields of compounds 4a and 4b were 53.6% (40.73 g) and 52.3% (39.78 g), respectively.
References
[1] Bulletin des Societes Chimiques Belges, 1969, vol. 78, p. 571 - 582
[2] Chemistry Letters, 1989, p. 1849 - 1852
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 13, p. 6047 - 6060
[4] Polyhedron, 2016, vol. 105, p. 137 - 149
2-Methyl-6-nitroaniline Preparation Products And Raw materials
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View Lastest Price from 2-Methyl-6-nitroaniline manufacturers
- Product
- 2-Methyl-6-nitroaniline 570-24-1
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-17
- Product
- 2-Methyl-6-nitroaniline 570-24-1
- Price
- US $83.72/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 99.0%HPLC
- Supply Ability
- 10tons/month
- Release date
- 2021-09-23
- Product
- 2-Methyl-6-nitroaniline 570-24-1
- Price
- US $10.70/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-23