5-BROMO-2-METHYL-3-NITROBENZOIC ACID
- Product Name
- 5-BROMO-2-METHYL-3-NITROBENZOIC ACID
- CAS No.
- 107650-20-4
- Chemical Name
- 5-BROMO-2-METHYL-3-NITROBENZOIC ACID
- Synonyms
- AKOS BB-9545;-3-nitrobenzoic acid;5-Bromo-2-methyl-3-nitrobenzoicAci;5-BROMO-2-METHYL-3-NITROBENZOIC ACID;Benzoic acid, 5-broMo-2-Methyl-3-nitro-;5-BROMO-2-METHYL-3-NITROBENZOIC ACID ISO 9001：2015 REACH
- CBNumber
- CB8460277
- Molecular Formula
- C8H6BrNO4
- Formula Weight
- 260.04
- MOL File
- 107650-20-4.mol
5-BROMO-2-METHYL-3-NITROBENZOIC ACID Property
- Boiling point:
- 377.0±42.0 °C(Predicted)
- Density
- 1.777±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2?+-.0.20(Predicted)
- InChI
- InChI=1S/C8H6BrNO4/c1-4-6(8(11)12)2-5(9)3-7(4)10(13)14/h2-3H,1H3,(H,11,12)
- InChIKey
- DXUUJILVHXQDCV-UHFFFAOYSA-N
- SMILES
- C1(C(C)=C(C(=O)O)C=C(Br)C=1)[N+]([O-])=O
N-Bromosuccinimide Price
- Product number
- B687510
- Product name
- 5-Bromo-2-methyl-3-nitrobenzoicAcid
- Packaging
- 10g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- X8853
- Product name
- 5-Bromo-2-methyl-3-nitrobenzoicacid
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- CS-M2396
- Product name
- Benzoicacid,5-bromo-2-methyl-3-nitro-
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
- Product number
- CS-M2396
- Product name
- Benzoicacid,5-bromo-2-methyl-3-nitro-
- Packaging
- 5g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- FB32995
- Product name
- 5-Bromo-2-methyl-3-nitrobenzoic acid
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
5-BROMO-2-METHYL-3-NITROBENZOIC ACID Chemical Properties,Usage,Production
Uses
5-Bromo-2-methyl-3-nitrobenzoic Acid is a reactant in the preparation of EPZ005687 (E592200), a potent and selective inhibitor of EZH2.
Synthesis
1975-50-4
107650-20-4
General procedure for the synthesis of 2-methyl-3-nitro-5-bromobenzoic acid from 2-methyl-3-nitrobenzoic acid: N-bromosuccinimide (15 g, 84.3 mmol) was added to a concentrated sulfuric acid solution (60 mL) containing 2-methyl-3-nitrobenzoic acid (15 g, 82.8 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction solution was slowly poured into ice water (400 mL). The precipitate was collected by filtration and dried under vacuum to give 21 g of the target product 2-methyl-3-nitro-5-bromobenzoic acid in 98% yield.
References
[1] Patent: US2012/264734, 2012, A1. Location in patent: Page/Page column 100
[2] Patent: WO2012/142513, 2012, A1. Location in patent: Page/Page column 288
[3] Patent: US2014/107122, 2014, A1. Location in patent: Paragraph 0157; 0158
[4] Patent: WO2003/99275, 2003, A1. Location in patent: Page 101
[5] Patent: US2007/219212, 2007, A1. Location in patent: Page/Page column 23
5-BROMO-2-METHYL-3-NITROBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
5-BROMO-2-METHYL-3-NITROBENZOIC ACID Suppliers
- Tel
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- Fax
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
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- kevinbanks@molekula.com
- Country
- United Kingdom
- ProdList
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- Advantage
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View Lastest Price from 5-BROMO-2-METHYL-3-NITROBENZOIC ACID manufacturers
- Product
- 5-Bromo-2-methyl-3-nitrobenzoic acid 107650-20-4
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-13
- Product
- 5-BROMO-2-METHYL-3-NITROBENZOIC ACID 107650-20-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-BROMO-2-METHYL-3-NITROBENZOIC ACID 107650-20-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09