5,7-Dihydrox -4'-methoxyisoflavone

ChemicalBook > CAS DataBase List > 5,7-Dihydrox -4'-methoxyisoflavone

5,7-Dihydrox -4'-methoxyisoflavone

Product Name: 5,7-Dihydrox -4'-methoxyisoflavone
CAS No.: 491-80-5
Chemical Name: 5,7-Dihydrox -4'-methoxyisoflavone
Synonyms: BIOCHANIN A;BIOCHANIN;BIOCHANIN A (AHP);OlMelin;Pratensol;Bilchanin A;Biochani,Olmelin;5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one;5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one;NSC 123538
CBNumber: CB8474490
Molecular Formula: C16H12O5
Formula Weight: 284.26
MOL File: 491-80-5.mol

Less

5,7-Dihydrox -4'-methoxyisoflavone Property

Melting point:: 210-213 °C(lit.)
Boiling point:: 340-355 °C(Press: 0.5 Torr)
Density: 1.420±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: acetone: 10 mg/mL, clear, brown
form: Powder
pka: 6.50±0.20(Predicted)
color: Off-White to Beige
Water Solubility: Soluble in water (<1 mg/ml at 25°C), chloroform, methanol, DMSO (57 mg/ml at 25°C), and ethanol (9 mg/ml at 25°C).
λmax: 263nm(EtOH)(lit.)
BRN: 278107
LogP: 3.341 (est)
CAS DataBase Reference: 491-80-5(CAS DataBase Reference)
EPA Substance Registry System: 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)- (491-80-5)

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: DJ3002500
F: 10
TSCA: Yes
HS Code: 29329990

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL80012
Product name: Biochanin A
Purity: phyproof? Reference Substance
Packaging: 25MG
Price: $259
Updated: 2024/03/01

Sigma-Aldrich

Product number: 92142
Product name: Biochanin A
Purity: analytical standard
Packaging: 50mg
Price: $183
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1071381
Product name: Biochanin A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $344
Updated: 2024/03/01

TCI Chemical

Product number: B4098
Product name: Biochanin A
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $217
Updated: 2024/03/01

TCI Chemical

Product number: B4098
Product name: Biochanin A
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $728
Updated: 2024/03/01

Less

5,7-Dihydrox -4'-methoxyisoflavone Chemical Properties,Usage,Production

Description

Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity. Also known as 4’-methyl genistein, biochanin A can be metabolized in vivo to genistein , another phytoestrogen with diverse effects. Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (EC₅₀ = 19 μM) and has also been shown to activate a PPARα promoter. Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis. Biochanin A also inhibits fatty acid amide hydrolase (IC₅₀ = 2.4 μM) and acts as an agonist of the aryl hydrocarbon receptor (EC₅₀ = 0.25 μM).

Chemical Properties

Off-White Solid

Uses

phytoestrogen

Uses

It has putative benefits in dietary cancer prophylaxis. It has also been found to inhibit fatty acid amide hydrolase and to act as agonist of PPARgamma, nuclear receptor that is current pharmacological target for the treatment of diabetes type 2. It acts as an antineoplastic agent. It is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels. Induction of sulfotransferases for xenobiotic detoxification has been proposed as a mechanism of its cancer preventive effects. It is a nitric oxide synthase inhibitor and apoptosis inducer

Uses

An isoflavone with anticancer proliferation, differentiation and chemopreventitive properties. Inhibits metabolic activation of benzo[a]pyrene

Definition

ChEBI: Biochanin A is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis. It has a role as a phytoestrogen, a plant metabolite, an EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor, a tyrosine kinase inhibitor and an antineoplastic agent. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It is a conjugate acid of a biochanin A(1-).

General Description

Biochanin A (BCA) is synthesized in vitro from phloroglucinol. A series of steps involving Friedel?Crafts reaction results in an intermediate product 1-(2,4,6-trihydroxyphenyl)-2-(4 methoxyphenyl) ethanone, which post cyclization leads to BCA. It is catabolized to isoflavone genistein post ingestion.

Biochem/physiol Actions

Biochanin A is an isoflavone phytoestrogen found in red clover (Trifolium pratense) that is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels. Induction of sulfotransferases for xenobiotic detoxification has been proposed as a mechanism of its cancer preventive effects.

5,7-Dihydrox -4'-methoxyisoflavone Preparation Products And Raw materials

Raw materials

Preparation Products

Less

5,7-Dihydrox -4'-methoxyisoflavone Suppliers

Americas 1 Australia 1 Belgium 1 Canada 1 China 308 Czech Republic 1 Europe 1 France 2 Germany 4 India 8 Japan 3 Switzerland 1 United Kingdom 8 United States 43 Global 383

Hangzhou FST Pharmaceutical Co., Ltd

Tel: 0571-88938521 18667135863
Fax: +86-571-88938660
Email: ps.wu@eyougene.com
Country: China
ProdList: 115
Advantage: 60

Shanxi Yuning Biotechnology Co., Ltd.

Tel: 13623677056
Email: 1639455302@qq.com
Country: China
ProdList: 265
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9413
Advantage: 66

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8843
Advantage: 52

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 021-51613915-820 13611835272
Fax: 021 51613951
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 9734
Advantage: 57

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2871
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

XI'AN KPC-CN BIOLOGICAL TECHNOLOGY CO.,LTD.

Tel: 86-029-85456576
Fax: 86-029-85456576-808
Email: daisy_wang@vip.163.com
Country: China
ProdList: 292
Advantage: 55

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9545
Advantage: 55

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

Cheng Du Pufeide Biotechnology Co., Ltd.

Tel: 028-82610909 13388174823
Fax: 8171-1798
Email: scglp@glp-china.com
Country: China
ProdList: 1064
Advantage: 58

Chengdu Herbpurify Co.Ltd.

Tel: 18302802153 18981717076
Fax: 086-28-85377358
Email: 2355253619@qq.com
Country: China
ProdList: 1104
Advantage: 58

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3921
Advantage: 50

Shanghai Zhanshu Chemical Technology Co., Ltd

Tel: +86-21-58589556
Fax: +86-21-58589557
Country: China
ProdList: 413
Advantage: 55

Vientiane Tianjin Hengyuan Technology Co., Ltd.

Tel: 15722085254
Fax: 022-26358246
Email: phytochemical@126.com
Country: China
ProdList: 813
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Shanghai DiBai Chemicals Co., Ltd.

Tel: 021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3991
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Aspire Biological Technology Co., Ltd.

Tel: 021-61317773
Fax: 021-61486878
Email: sales@aspirebio.com
Country: China
ProdList: 2880
Advantage: 58

Shanghai CanSpecsci Instrument Co., Ltd.

Tel: 400-6087598 15021221957
Fax: 4006087598-8012
Email: order@canspecsci.com
Country: China
ProdList: 2045
Advantage: 56

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 7295
Advantage: 60

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-+86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 11481
Advantage: 59

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb6@aikonchem.com
Country: China
ProdList: 16684
Advantage: 50

Less

View Lastest Price from 5,7-Dihydrox -4'-methoxyisoflavone manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5,7-Dihydrox -4'-methoxyisoflavone 491-80-5
Price: US $1.00-100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 4000KG
Release date: 2024-07-08

PNP Biotech Co. Ltd

Product: 5,7-Dihydrox -4'-methoxyisoflavone 491-80-5
Price: US $0.00/kg
Min. Order: 25kg
Purity: HPLC>99%
Supply Ability: Inquiry
Release date: 2022-09-16

Shanghai Standard Technology Co., Ltd.

Product: Biochanin A 491-80-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-25

491-80-5, 5,7-Dihydrox -4'-methoxyisoflavoneRelated Search:

p-Anisidine Riboflavin Genistein Theaflavin 1-Hydroxyethylidene-1,1-diphosphonic acid Riboflavin 5'-Monophosphate Sodium Salt Anisole Bensulfuron methyl Kresoxim-methyl Methylparaben Aloe emodin p-Anisaldehyde Emodin Triclosan Thiophanate-methyl Methyl acrylate Curcumin (Trifluoromethoxy)benzene

Biochani,Olmelin

5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one

BIOCHANIN A (AHP)

BIOCHANIN

5,7-DIHYDROXY-4''-METHOXYISOFLAVONE, 98% BIOCHANIN A

5,7-Dihydrox -4'-methoxyisoflavone

5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one

Biochanin A, (5,7-Dihydroxy-4’-methoxyisoflavone)

Biochanin A，Genistein 4'-methyl ether，5,7-Dihydrox -4'-methoxyisoflavone

3-(4-Methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one

4'-Methylgenistein

Bilchanin A

NSC 123538

Biochanin A (4-Methylgenistein)

OlMelin

Pratensol

Biochanin A,5,7-Dihydroxy-4′-methoxyisoflavone, Genistein 4′-methyl ether

5,7-Dihydrox -4'-methoxyisoflavone 491-80-5

7-hydroxy-3-(4-methoxyphenyl)-4-oxo-1-benzopyran-5-olate

5,7-dihydroxy-3-(4-methoxyphenyl)-4h-1-benzopyran-4-on

5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-Benzopyran-4-one

APIGENIN 4-METHYL ETHER

BIOCHANIN A

5,7-DIHYDROXY-4'-METHOXYISOFLAVONE

5,7-DIHYDROXY-4-METHOXYISOFLAVONE

Genistein 4′-methyl ether

5,7-dihydroxy-3-p-methoxyphenyl-4H-chromen-4-one

4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)-

5,7-Dihydroxy-4'-methoxyisoflavone Genistein 4'-methyl ether 5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one

Biochanin A &gt

Genistein Methyl Ether

Chickpea bud A

5,7-Dihydroxy-4'-methoxyisoflavone (Biochanin A)

TIANFUCHEM--High purity 491-80-5 5,7-Dihydrox -4'-methoxyisoflavone

Chickpea sproutin A

Chickpea A

5,7- Dihydroxy - 4'- methoxy Isoflovone (or) Biochanin-A

Chickpea sprout extract

Biochanin A 98%min

Chickpea dentin A

5,7-Dihydrox -4'-methoxyisoflavone

4-Methylgenistein|||Olmelin

Biochanin A(P) (AHP Verified)

Biochanin A-RM

491-80-5

Chromatography

Food & Beverage Standards

Food Residue Analysis

Analytical Standards

Analytical Chromatography Product Catalog

BioChemical

Cancer Research

Anti-proliferative Agents

Chemopreventive Agents

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).