Difenidol

Product Name: Difenidol
CAS No.: 972-02-1
Chemical Name: Difenidol
Synonyms: Nometic;Vontrol;SKF 478;SK&F-478;Cephadol;DIFENIDOL;DIPHENIDOL;SK&F No. 478-A;Difenidol USP/EP/BP;1-Piperidinebutanol, α,α-diphenyl-
CBNumber: CB8474607
Molecular Formula: C21H27NO
Formula Weight: 309.45
MOL File: 972-02-1.mol

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Difenidol Property

Melting point:: 104-105°
Boiling point:: 449.71°C (rough estimate)
Density: 1.0350 (rough estimate)
refractive index: 1.5614 (estimate)
NIST Chemistry Reference: Diphenidol(972-02-1)

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Safety

Hazardous Substances Data: 972-02-1(Hazardous Substances Data)
Toxicity: LD50 s.c. in rats: 50 mg/kg (Goldenthal)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0079965
Product name: DIFENIDOL
Purity: 95.00%
Packaging: 1G
Price: $921.69
Updated: 2021/12/16

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Difenidol Chemical Properties,Usage,Production

Originator

Vontrol,SKF,US,1967

Uses

Anti-emetic.

Definition

ChEBI: A tertiary alcohol that is butan-1-ol substituted by two phenyl groups at position 1 and a piperidin-1-yl group at position 4.

Manufacturing Process

2.6 grams magnesium, activated by means of iodine, is introduced into 20 cc of absolute ether and is caused to react with 0.6 cc of ethyl
omide. While warming gently, 16.2 grams (0.1 mol) of N-[1-chloropropyl-(3)]-piperidine in 40 cc of absolute ether are added and, after adding a further 0.5 cc of ethyl
omide, 14.5 grams (0.08 mol) of benzophenone in 50 cc of anhydrous ether are added in portions. The magnesium is used up fairly quickly and, after 10 hours, only traces are left. In working up, both with hydrochloric acid and with ammonium chloride, the hydrochloride of diphenyl-3-piperidinopropyl carbinol is precipitated as a dense precipitate. It is purified by recrystallization from chloroform-ethyl acetate. MP 212-214°C.

Therapeutic Function

Antinauseant

Trade name

Vontrol (Smith Kline & French), Cephadol (Nippon Shinyaku).

Difenidol Preparation Products And Raw materials

Raw materials

Preparation Products

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Difenidol Suppliers

China 21 Europe 2 United States 11 Global 34

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972-02-1, DifenidolRelated Search:

1-Butanol 2-Butanol m-Phenylenediamine Bis(2-ethylhexyl) phthalate p-Phenylenediamine Dichlorodiphenylsilane 1,5-Diphenylcarbazide Benzophenone Phthalic acid 3,4'-DIAMINODIPHENYLMETHANE Potassium hydrogen phthalate Chlorodiphenylphosphine tert-Butanol 2-Methyl-1-propanol (+-) 1-BROMO-2-METHYLBUTANE 95 Difenidol hydrochloride (JP14),1,1-Diphenyl-4-piperidino-1-butanol, Difenidol,DIFENIDOL HYDROCHLORIDE Benzhydrol P-FLUORO-HEXAHYDRO-SILA-DIFENIDOL,HEXAHYDRO-SILA-DIFENIDOL HYDROCHLORIDE P -FLUORO ANALOG (P-F-,p-fluorohexahydro-sila-difenidol hydrochloride

1,1-Diphenyl-4-(1-piperidinyl)-1-butanol

1-Piperidinebutanol, alpha,alpha-diphenyl-

alpha,alpha-Diphenyl-1-piperidinebutanol

Benzhydrol, alpha-(3-piperidinopropyl)-

Nometic

SK&F No. 478-A

SK&F-478

SKF 478

Vontrol

DIFENIDOL

DIPHENIDOL

1,1-diphenyl-4-(1-piperidyl)butan-1-ol

Diphenidol (base and/or unspecified salts)

Cephadol

1,1-Diphenyl-4-piperidinobutan-1-ol

α,α-Diphenyl-1-piperidine-(1-butanol)

1,1-diphenyl-4-(piperidin-1-yl)butan-1-ol

1-Piperidinebutanol, α,α-diphenyl-

Difenidol USP/EP/BP

972-02-1

Piperidines

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