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Difenidol

Product Name
Difenidol
CAS No.
972-02-1
Chemical Name
Difenidol
Synonyms
Nometic;Vontrol;SKF 478;SK&F-478;Cephadol;DIFENIDOL;DIPHENIDOL;SK&F No. 478-A;Difenidol USP/EP/BP;1-Piperidinebutanol, α,α-diphenyl-
CBNumber
CB8474607
Molecular Formula
C21H27NO
Formula Weight
309.45
MOL File
972-02-1.mol
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Difenidol Property

Melting point:
104-105°
Boiling point:
449.71°C (rough estimate)
Density 
1.0350 (rough estimate)
refractive index 
1.5614 (estimate)
NIST Chemistry Reference
Diphenidol(972-02-1)
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Safety

Hazardous Substances Data
972-02-1(Hazardous Substances Data)
Toxicity
LD50 s.c. in rats: 50 mg/kg (Goldenthal)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CHM0079965
Product name
DIFENIDOL
Purity
95.00%
Packaging
1G
Price
$921.69
Updated
2021/12/16
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Difenidol Chemical Properties,Usage,Production

Originator

Vontrol,SKF,US,1967

Uses

Anti-emetic.

Definition

ChEBI: A tertiary alcohol that is butan-1-ol substituted by two phenyl groups at position 1 and a piperidin-1-yl group at position 4.

Manufacturing Process

2.6 grams magnesium, activated by means of iodine, is introduced into 20 cc of absolute ether and is caused to react with 0.6 cc of ethyl
omide. While warming gently, 16.2 grams (0.1 mol) of N-[1-chloropropyl-(3)]-piperidine in 40 cc of absolute ether are added and, after adding a further 0.5 cc of ethyl
omide, 14.5 grams (0.08 mol) of benzophenone in 50 cc of anhydrous ether are added in portions. The magnesium is used up fairly quickly and, after 10 hours, only traces are left. In working up, both with hydrochloric acid and with ammonium chloride, the hydrochloride of diphenyl-3-piperidinopropyl carbinol is precipitated as a dense precipitate. It is purified by recrystallization from chloroform-ethyl acetate. MP 212-214°C.

Therapeutic Function

Antinauseant

Trade name

Vontrol (Smith Kline & French), Cephadol (Nippon Shinyaku).

Difenidol Preparation Products And Raw materials

Raw materials

Preparation Products

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Difenidol Suppliers

China 23 Europe 2 United States 11 Global 36
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View Lastest Price from Difenidol manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Difenidol 972-02-1
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-06
Dideu Industries Group Limited
Product
Difenidol 972-02-1
Price
US $1.10/g
Min. Order
1g
Purity
0.999
Supply Ability
100 Tons min
Release date
2021-08-04

972-02-1, DifenidolRelated Search:

1-Butanol 2-Butanol m-Phenylenediamine Bis(2-ethylhexyl) phthalate p-Phenylenediamine Dichlorodiphenylsilane 1,5-Diphenylcarbazide Benzophenone Phthalic acid 3,4'-DIAMINODIPHENYLMETHANE Potassium hydrogen phthalate Chlorodiphenylphosphine tert-Butanol 2-Methyl-1-propanol (+-) 1-BROMO-2-METHYLBUTANE 95 Difenidol hydrochloride (JP14),1,1-Diphenyl-4-piperidino-1-butanol, Difenidol,DIFENIDOL HYDROCHLORIDE Benzhydrol P-FLUORO-HEXAHYDRO-SILA-DIFENIDOL,HEXAHYDRO-SILA-DIFENIDOL HYDROCHLORIDE P -FLUORO ANALOG (P-F-,p-fluorohexahydro-sila-difenidol hydrochloride

  • 1,1-Diphenyl-4-(1-piperidinyl)-1-butanol
  • 1-Piperidinebutanol, alpha,alpha-diphenyl-
  • alpha,alpha-Diphenyl-1-piperidinebutanol
  • Benzhydrol, alpha-(3-piperidinopropyl)-
  • Nometic
  • SK&F No. 478-A
  • SK&F-478
  • SKF 478
  • Vontrol
  • DIFENIDOL
  • DIPHENIDOL
  • 1,1-diphenyl-4-(1-piperidyl)butan-1-ol
  • Diphenidol (base and/or unspecified salts)
  • Cephadol
  • 1,1-Diphenyl-4-piperidinobutan-1-ol
  • α,α-Diphenyl-1-piperidine-(1-butanol)
  • 1,1-diphenyl-4-(piperidin-1-yl)butan-1-ol
  • 1-Piperidinebutanol, α,α-diphenyl-
  • Difenidol USP/EP/BP
  • 972-02-1
  • Piperidines
  • Heterocyclic Building Blocks
  • Building Blocks