Difenidol Property

Melting point:

104-105°

Boiling point:

449.71°C (rough estimate)

Density 

1.0350 (rough estimate)

refractive index 

1.5614 (estimate)

NIST Chemistry Reference

Diphenidol(972-02-1)

Safety

Hazardous Substances Data

972-02-1(Hazardous Substances Data)

Toxicity

LD50 s.c. in rats: 50 mg/kg (Goldenthal)

Hazard and Precautionary Statements (GHS)

Difenidol Chemical Properties,Usage,Production

Originator

Vontrol,SKF,US,1967

Uses

Anti-emetic.

Definition

ChEBI: A tertiary alcohol that is butan-1-ol substituted by two phenyl groups at position 1 and a piperidin-1-yl group at position 4.

Manufacturing Process

2.6 grams magnesium, activated by means of iodine, is introduced into 20 cc of absolute ether and is caused to react with 0.6 cc of ethyl
omide. While warming gently, 16.2 grams (0.1 mol) of N-[1-chloropropyl-(3)]-piperidine in 40 cc of absolute ether are added and, after adding a further 0.5 cc of ethyl
omide, 14.5 grams (0.08 mol) of benzophenone in 50 cc of anhydrous ether are added in portions. The magnesium is used up fairly quickly and, after 10 hours, only traces are left. In working up, both with hydrochloric acid and with ammonium chloride, the hydrochloride of diphenyl-3-piperidinopropyl carbinol is precipitated as a dense precipitate. It is purified by recrystallization from chloroform-ethyl acetate. MP 212-214°C.

Therapeutic Function

Antinauseant

Trade name

Vontrol (Smith Kline & French), Cephadol (Nippon Shinyaku).