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Aristolochic acid

Product Name
Aristolochic acid
CAS No.
313-67-7
Chemical Name
Aristolochic acid
Synonyms
TR 1736;tardolyt;nsc-50413;NSC 11926;birthwort;Descresept;Aristolochic;aristolochin;aristolochine;Aristolochia A
CBNumber
CB8481548
Molecular Formula
C17H11NO7
Formula Weight
341.27
MOL File
313-67-7.mol
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Aristolochic acid Property

Melting point:
260 °C
Boiling point:
476.92°C (rough estimate)
Density 
1.3162 (rough estimate)
refractive index 
1.4500 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: soluble
form 
powder
pka
2.99±0.20(Predicted)
color 
yellow
InChIKey
LIDQMWRBMLSXLL-UHFFFAOYSA-N
CAS DataBase Reference
313-67-7(CAS DataBase Reference)
IARC
1 (Vol. 82, 100A) 2012, 1 (Vol. 82, 100A) 2012
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Safety

Hazard Codes 
T
Risk Statements 
25-68-36/37/38-23/24/25-45
Safety Statements 
7-35-45-36/37/39-26-53
RIDADR 
UN 1544 6.1/PG 3
WGK Germany 
3
RTECS 
CF3325000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29329990
Toxicity
LD50 in male, female mice, male, female rats (mg/kg): 38.4, 70.1, 82.5, 74.0 i.v.; 55.9, 106.1, 203.4, 183.9 orally (Mengs)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A5512
Product name
Aristolochic acid I
Purity
powder
Packaging
25mg
Price
$77
Updated
2020/08/18
Sigma-Aldrich
Product number
Y0001185
Product name
Aristolochic acid I
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
A5512
Product name
Aristolochic acid I
Purity
powder
Packaging
100mg
Price
$243
Updated
2020/08/18
Cayman Chemical
Product number
21520
Product name
Aristolochic Acid
Purity
≥98%
Packaging
10mg
Price
$25
Updated
2021/03/22
Cayman Chemical
Product number
21520
Product name
Aristolochic Acid
Purity
≥98%
Packaging
25mg
Price
$47
Updated
2021/03/22
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Aristolochic acid Chemical Properties,Usage,Production

Description

Aristolochic acid first appeared in Chinese medicine in the fifth century AD, while it was used to treat kidney and urinary diseases, as well as gout, snakebites, and a variety of other ailments. In many of these cases, aristolochic acid was just one of the main components of the salves. In the first century, aristolochic acid was first described as a composition of ingested medicine to treat symptoms such as asthma, hiccups, pains, and spasms.

Chemical Properties

Shiny brown leaflets or a yellow or white powder.

Physical properties

Appearance: brown sheet crystal or yellow powder. Solubility: practically insoluble in water and soluble in ethanol, chloroform, ethyl ether, acetone, glacial acetic acid, and aniline. Melting point: 260–265?°C (500–509?°F; 533–538?K).

History

At a clinic in Brussels, Belgium, a group of women who had all taken the same weight loss supplement, Aristolochia fangchi, which contained aristolochic acid, was first diagnosed with aristolochic acid poisoning. Balkan endemic nephropathy (BEN) was later found to be also the result of aristolochic acid (AA) consumption. Balkan endemic nephropathy is likely caused by low-level AA exposure, possibly from the contamination of wheat flour seeds by Aristolochia clematitis. BEN falls under the umbrella of what is now known as aristolochic acid nephropathy, the prevalent symptom of AA poisoning .

Uses

PLA2 inhibitor

Uses

Aristolochic acids occur in Aristolochiaceae and in butterflies feeding on these plants. One of a group of fourteen known, substituted 1-phenanthrenecarboxylic acids

Definition

ChEBI: A monocarboxylic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is b th carcinogenic and nephrotoxic.

Indications

Due to the widely associated kidney problems and urothelial cancers, the FDA has issued warnings regarding consumption of AA-containing supplements.

brand name

Acidum aristolchicum;Descresepet;Fago-araxin;Fluocinova;Predno-facilus haemota.

World Health Organization (WHO)

Extracts of aristolochiaceae have traditionally been used as a bitter for which a broad range of therapeutic effects has been claimed. Aristolochic acid is claimed to promote phagocytosis and to have immunostimulant activity. However, in 1981, a three-month toxicity study in rats revealed the carcinogenic potential of aristolochic acid and preparations containing this substance have since been withdrawn in several countries.

Pharmacology

In 1992, some cases of women present with a rapidly progressive renal failure after having a slimming regimen including powdered extracts of Chinese herbal preparations. This outbreak of renal failure eventually resulted in about 100 cases in 1998, 70% of them being in end-stage renal disease (ESRD) . Recent research has confirmed that the main reason leading to renal injury is aristolochic acid found in many Chinese herbs . Aristolochic acid, a potent human carcinogen from Aristolochia plants, is associated with the incidence of urothelial carcinoma in the upper urinary tract (UUC). After the metabolic activation, aristolochic acid reacted with DNA to form aristolactam (AL)-DNA adducts. Mainly pathological changes are in renal cortex, where they serve as a specific biomarker, and are also found in urothelium, where they lead to a unique mutational signature in the TP53 tumorsuppressor gene. The conclusion is that exposure to aristolochic acid gives rise to the incidence of UUC, a finding with significant implications for the global public health .

Clinical Use

Aristolochia species are nephrotoxic and carcinogenic, and FDA has issued warnings regarding consumption of AA-containing supplements.

Safety Profile

Confirmed carcinogen. Poison by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NO,. Potentially Toxic Chemicals: April 1982." Vol. 5 No. 1: The Ministry of Health of the Federal Republic of Germany has withdrawn from the national market drugs containing aristolochic acid. The decision resulted from the demonstration of a carcinogenic potential in a three-month ingestion toxicity study undertaken in rats. Aristolochic acid is claimed to promote phagocytosis and to have immunostimulant activity. A growth-inhibiting effect on experimentally induced tumors has been described, but this effect has not been shown to have any clinical relevance. Extracts of species of Aristolochiacea have tradtionally been used as a bitter, and a broad range of therapeutic effects has been claimed.

Potential Exposure

Aristolochic acids are alkaloids used primarily as a chemical intermediate for pharmaceuticals, lab chemicals, herbal extract, drug.

Shipping

UN1544 Alkaloids, solid, n.o.s. or Alkaloid salts, solid, n.o.s. poisonous, Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required. PG III.

Incompatibilities

Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. All federal, state, and local environmental regulations must be observed.

Aristolochic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Aristolochic acid Suppliers

Vientiane Tianjin Hengyuan Technology Co., Ltd.
Tel
15722085254
Fax
022-26358246
Email
phytochemical@126.com
Country
China
ProdList
813
Advantage
55
Nanjing Dasf Biotechnology Co., Ltd.
Tel
025-85846866-
Fax
025-83144123
Email
eric@dasfbio.com
Country
China
ProdList
1996
Advantage
58
Shanghai Hewu Biotechnology Co., LTD
Tel
021-57886085
Email
shhebio@126.com
Country
CHINA
ProdList
7977
Advantage
58
Nanjing Bencao Yikang Biotechnology Co., Ltd
Tel
025-69790911-
Email
522593521@qq.com
Country
China
ProdList
944
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5948
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100-
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9638
Advantage
66
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
Chengdu XiYa Chemical Technology Co., Ltd.
Tel
;
Fax
0539-6365991
Email
sale@xiyashiji.com;3007716753@qq.com
Country
China
ProdList
10578
Advantage
57
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View Lastest Price from Aristolochic acid manufacturers

career henan chemical co
Product
Aristolochic acid 313-67-7
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1 ton
Release date
2018-08-20

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