ChemicalBook > CAS DataBase List > 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- Product Name
- 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- CAS No.
- 2093416-32-9
- Chemical Name
- 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- Synonyms
- Thalidomide-PEG2-C2-NH2;Thalidomide-NH-PEG2-C2-NH2;Thalidomide-4-NH-PEG2-C2-NH2;4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
- CBNumber
- CB84849371
- Molecular Formula
- C19H24N4O6
- Formula Weight
- 404.42
- MOL File
- 2093416-32-9.mol
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N-Bromosuccinimide Price
DC Chemicals
- Product number
- 027582
- Product name
- Thalidomide-PEG2-C2-NH2
- Packaging
- 002
- Price
- $850
- Updated
- 2021/12/16
A1 Biochem Labs
- Product number
- A1-26739
- Product name
- 4-((2-(2-(2-Aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- Purity
- 95%
- Packaging
- 1g
- Price
- $1200
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC50056
- Product name
- Thalidomide-PEG2-C2-NH2
- Packaging
- 1g
- Price
- $1700
- Updated
- 2021/12/16
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4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties,Usage,Production
Biological Activity
Thalidomide-PEG2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References
[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.
4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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2093416-32-9, 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneRelated Search:
Thalidomide-O-amido-C2-NH2
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Thalidomide-NH-C6-NH2 TFA
4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
E3 ligase Ligand-Linker Conjugates 15
Thalidomide-O-amido-C2-NH2
Thalidomide-NH-PEG2-C2-NH2 hydrochloride
Thalidomide-NH-PEG2-C2-NH2 (TFA)