ChemicalBook > CAS DataBase List > 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

Product Name
4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
CAS No.
2093386-50-4
Chemical Name
4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
Synonyms
Thalidomide-NH-C6-NH2;Thalidomide-4-NH-C6-NH2;4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl;4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione, 4-[(6-aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-;4-[(6-aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CBNumber
CB74796319
Molecular Formula
C19H24N4O4
Formula Weight
372.42
MOL File
2093386-50-4.mol
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4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Property

Boiling point:
648.2±55.0 °C(Predicted)
Density 
1.342±0.06 g/cm3(Predicted)
pka
10.75±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals
Product number
027581
Product name
Thalidomide-NH-C6-NH2
Packaging
001
Price
$400
Updated
2021/12/16
DC Chemicals
Product number
027581
Product name
Thalidomide-NH-C6-NH2
Packaging
002
Price
$700
Updated
2021/12/16
Acrotein
Product number
AS00955
Product name
4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneHCl
Purity
97%
Packaging
0.5g
Price
$825
Updated
2021/12/16
A1 Biochem Labs
Product number
6591785
Product name
4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dionehydrochloride
Purity
95%
Packaging
2.5g
Price
$1200
Updated
2021/12/16
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4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Chemical Properties,Usage,Production

Uses

Thalidomide-NH-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Biological Activity

Thalidomide-NH-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

IC 50

Cereblon

References

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Suppliers

China 23 United States 2 Global 25
Daicel Chiral Technologies (China)CO.,LTD
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2093386-50-4, 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HClRelated Search:

Thalidomide-O-amido-C2-NH2 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione -alkylC5-amine Thalidomide-NH-C6-NH2 TFA E3 ligase Ligand-Linker Conjugates 15 Thalidomide-O-amido-C2-NH2 Thalidomide-NH-PEG2-C2-NH2 hydrochloride Thalidomide-NH-PEG2-C2-NH2 (TFA) 5-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)- 2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]- 1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- 5-[(8-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)- β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- 5-[(5-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 5-[(7-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Thalidomide-O-C10-NH2

  • 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
  • Thalidomide-NH-C6-NH2
  • 1H-Isoindole-1,3(2H)-dione, 4-[(6-aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-
  • 4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
  • Thalidomide-4-NH-C6-NH2
  • 4-[(6-aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
  • 4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
  • 2093386-50-4