4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

Product Name: 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
CAS No.: 2093386-50-4
Chemical Name: 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
Synonyms: Thalidomide-NH-C6-NH2;Thalidomide-4-NH-C6-NH2;4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl;1H-Isoindole-1,3(2H)-dione, 4-[(6-aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-;4-[(6-aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CBNumber: CB74796319
Molecular Formula: C19H24N4O4
Formula Weight: 372.42
MOL File: 2093386-50-4.mol

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4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Property

Boiling point:: 648.2±55.0 °C(Predicted)
Density: 1.342±0.06 g/cm3(Predicted)
pka: 10.75±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: 027581
Product name: Thalidomide-NH-C6-NH2
Packaging: 001
Price: $400
Updated: 2021/12/16

DC Chemicals

Product number: 027581
Product name: Thalidomide-NH-C6-NH2
Packaging: 002
Price: $700
Updated: 2021/12/16

Acrotein

Product number: AS00955
Product name: 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneHCl
Purity: 97%
Packaging: 0.5g
Price: $825
Updated: 2021/12/16

A1 Biochem Labs

Product number: 6591785
Product name: 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dionehydrochloride
Purity: 95%
Packaging: 2.5g
Price: $1200
Updated: 2021/12/16

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4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Chemical Properties,Usage,Production

Biological Activity

Thalidomide-NH-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Suppliers

China 19 United States 2 Global 21

Daicel Chiral Technologies (China)CO.,LTD

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2093386-50-4, 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HClRelated Search:

Thalidomide-O-amido-C2-NH2 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione -alkylC5-amine Thalidomide-NH-C6-NH2 TFA E3 ligase Ligand-Linker Conjugates 15 Thalidomide-O-amido-C2-NH2 Thalidomide-NH-PEG2-C2-NH2 hydrochloride Thalidomide-NH-PEG2-C2-NH2 (TFA)

4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

Thalidomide-NH-C6-NH2

1H-Isoindole-1,3(2H)-dione, 4-[(6-aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-

4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione

Thalidomide-4-NH-C6-NH2

4-[(6-aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

2093386-50-4