ChemicalBook > CAS DataBase List > 5-Methylsalicylamide

5-Methylsalicylamide

Product Name
5-Methylsalicylamide
CAS No.
39506-61-1
Chemical Name
5-Methylsalicylamide
Synonyms
5-METHYLSALICYAMIDE;5-METHYL SALICYLAMIDE;5-Methyl salicylamide ,98%;8023 5-METHYL SALICYLAMIDE;2-HYDROXY-5-METHYLBENZAMIDE;Benzamide, 2-hydroxy-5-methyl-;Benzamide, 2-hydroxy-5-methyl- (9CI)
CBNumber
CB8488002
Molecular Formula
C8H9NO2
Formula Weight
151.16
MOL File
39506-61-1.mol
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5-Methylsalicylamide Property

Melting point:
182 °C
Boiling point:
278.9±33.0 °C(Predicted)
Density 
1.230±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
8.67±0.18(Predicted)
color 
White to Off-White
CAS DataBase Reference
39506-61-1(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CHM0027403
Product name
5-METHYL SALICYLAMIDE
Purity
95.00%
Packaging
25G
Price
$1685.72
Updated
2021/12/16
Ambeed
Product number
A140736
Product name
2-Hydroxy-5-methylbenzamide
Purity
95+%
Packaging
1g
Price
$55
Updated
2021/12/16
Ambeed
Product number
A140736
Product name
2-Hydroxy-5-methylbenzamide
Purity
95+%
Packaging
5g
Price
$160
Updated
2021/12/16
Ambeed
Product number
A140736
Product name
2-Hydroxy-5-methylbenzamide
Purity
95+%
Packaging
10g
Price
$246
Updated
2021/12/16
Crysdot
Product number
CD12075626
Product name
2-Hydroxy-5-methylbenzamide
Purity
95+%
Packaging
10g
Price
$302
Updated
2021/12/16
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5-Methylsalicylamide Chemical Properties,Usage,Production

Synthesis

22717-57-3

39506-61-1

General Steps: 1. 500 mg (3.01 mmol) of methyl 2-hydroxy-5-methylbenzoate was dissolved in 2 mL of dioxane and 2 mL of 28% aqueous ammonium hydroxide was added. The reaction mixture was heated at 80°C for 20 hours and subsequently concentrated to dryness by rotary evaporation. The resulting light brown solid was ground with ether to remove the unreacted ester to give 480 mg (2.89 mmol, 96% yield) of pure 2-hydroxy-5-methylbenzamide. 2. 26 mg (0.083 mmol) of N-[4,8-dimethoxyquinolin-2-yl]carbonyl]-4-piperidinone (prepared as described in Example 44), 12.5 mg (0.083 mmol) of 2-hydroxy-5-methylbenzamide, and 0.020 mL of morpholine were dissolved in 2 mL of methanol and the reaction was carried out at reflux for 20 hours. After completion of the reaction, the mixture was diluted with ethyl acetate, washed sequentially with water and brine, and the organic layer was dried over anhydrous sodium sulfate. After the solvent was removed by rotary evaporation, the crude product was purified by preparative thin layer chromatography (TLC) to afford 20 mg (0.045 mmol, 54% yield) of 1'-[4,8-dimethoxyquinolin-2-yl)carbonyl]-6-methylspiro[2H-1,3-benzoxazin-2,4'-piperidin]-4-(3H)-one (compound 137). Identification data of compound 137: 1H NMR (DMSO-d6): δ 2.28 (s, 3H), 3.95 (s, 3H), 4.06 (s, 3H), 6.98 (d, 1H), 7.19 (s, 1H), 7.23 (d, 1H), 7.33 (d, 1H), 7.52 (d, 1H), 7.56 (d, 1H), 7.68 (d, 1H), 8.77 (s, 1H). MS m/z: 448.1 (M + H)+, 470.0 (M + Na)+.

References

[1] Patent: US2010/9982, 2010, A1. Location in patent: Page/Page column 69-70
[2] Justus Liebigs Annalen der Chemie, 1924, vol. 439, p. 10

5-Methylsalicylamide Preparation Products And Raw materials

Raw materials

Toluene Acetyl chloride Triethylamine Tetrahydrofuran Dichloromethane Thionyl chloride 5-Methylsalicylic acid Ammonia

Preparation Products

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5-Methylsalicylamide Suppliers

China 44 Europe 3 Germany 1 India 1 Switzerland 1 Ukraine 1 United Kingdom 6 United States 10 Global 67
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39506-61-1, 5-MethylsalicylamideRelated Search:

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