ALPHA-ZEARALENOL
- Product Name
- ALPHA-ZEARALENOL
- CAS No.
- 36455-72-8
- Chemical Name
- ALPHA-ZEARALENOL
- Synonyms
- ZEARALENOL;Α-ZEARALENOL;A-ZEARALENOL;(3S,7R,11E)-;α-Zearalenol;alfa-Zearalenol;ALPHA-ZEARALENOL;Zearalenol, alpha-;trans-α-Zearalenol;α-Zearalenol solution
- CBNumber
- CB8491950
- Molecular Formula
- C18H24O5
- Formula Weight
- 320.38
- MOL File
- 36455-72-8.mol
ALPHA-ZEARALENOL Property
- Melting point:
- 158-161°C
- Boiling point:
- 599.0±50.0 °C(Predicted)
- Density
- 1.174±0.06 g/cm3(Predicted)
- Flash point:
- 2℃
- storage temp.
- -20°C
- solubility
- ≤20mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 7.61±0.60(Predicted)
- color
- White to off-white
- Stability:
- Hygroscopic
Safety
- Hazard Codes
- Xn,T,F
- Risk Statements
- 20/21/22-40-52/53-68/20/21/22-36-11-62-48/20-63-46-45
- Safety Statements
- 36/37-61-16-45-53
- RIDADR
- UN 1648 3 / PGII
- WGK Germany
- 3
- F
- 8
- HS Code
- 29322090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H351Suspected of causing cancer
H371May cause damage to organs
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Z0166
- Product name
- α-Zearalenol
- Packaging
- 5mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- 35406
- Product name
- α-Zearalenol solution
- Purity
- 10 μg/mL in acetonitrile, analytical standard
- Packaging
- 1ml
- Price
- $835
- Updated
- 2024/03/01
- Product number
- 16549
- Product name
- α-Zearalenol
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 16549
- Product name
- α-Zearalenol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $286
- Updated
- 2024/03/01
- Product number
- Z0166
- Product name
- α-Zearalenol
- Packaging
- 10mg
- Price
- $424.2
- Updated
- 2024/03/01
ALPHA-ZEARALENOL Chemical Properties,Usage,Production
Description
α-Zearalenol is a major hepatic metabolite of zearalenone , a mycotoxin produced by fungi in food and animal feeds. It is a less potent agonist of estrogen receptors than the parent compound. However, α-zearalenol has pronounced effects on uterotropic activity, sperm motility, and preimplantation embryonic development.
Chemical Properties
Off-White Solid
Uses
α-Zearalenol is a mycotoxin produced by several species of Fusarium. α-Zearalenol exhibits pronounced estrogenic activity, being 3-fold more active than zearalenone. Contamination of grains, notably maize, by Fusarium species gives rise to high levels of zearalenol and is regarded as an important food quality issue for both humans and animal health.
Uses
α- Zearalenol may be used as an analytical reference standard for the determination of the analyte in traditional medicinal herbs, human and animal urine by various chromatography techniques.
Uses
The major metabolites of Zearalenone
Definition
ChEBI: Alpha-Zearalenol is a macrolide.
Biochem/physiol Actions
α-Zearalenol (α-ZOL) is a catabolite of zearalenone, synthesized majorly in granulosa cells, intestine and liver in pigs. It has estrogenic functionality. α-ZOL inhibits sperm motility in horse possibly by eliciting genotoxic effect. α-ZOL displays higher affinity towards estrogenic receptors.
in vitro
the binding characteristic of α-zea was less potent with estrogen receptors than the parent compound [2]. α-zearalenol showed pronounced effects on uterotropic activity [3]. α-zea inhibited normal sperm motility, but stimulated hyperactive motility in the remaining motile cells and simultaneously induced the acrosome reaction [4].
References
[1]. zinedine a, soriano j m, molto j c, et al. review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin[j]. food and chemical toxicology, 2007, 45(1): 1-18.
[2]. kiang d t, kennedy b j, pathre s v, et al. binding characteristics of zearalenone analogs to estrogen receptors[j]. cancer research, 1978, 38(11 part 1): 3611-3615.
[3]. mirocha c j, pathre s v, behrens j, et al. uterotropic activity of cis and trans isomers of zearalenone and zearalenol[j]. applied and environmental microbiology, 1978, 35(5): 986-987.
[4]. filannino a, stout t a e, gadella b m, et al. dose-response effects of estrogenic mycotoxins (zearalenone, alpha-and beta-zearalenol) on motility, hyperactivation and the acrosome reaction of stallion sperm[j]. reproductive biology and endocrinology, 2011, 9(1): 134.
ALPHA-ZEARALENOL Preparation Products And Raw materials
Raw materials
Preparation Products
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