ChemicalBook > CAS DataBase List > 2,6-DIMETHYL-PYRIDIN-4-YLAMINE

2,6-DIMETHYL-PYRIDIN-4-YLAMINE

Product Name: 2,6-DIMETHYL-PYRIDIN-4-YLAMINE
CAS No.: 3512-80-9
Chemical Name: 2,6-DIMETHYL-PYRIDIN-4-YLAMINE
Synonyms: -pyridin-4-yL;4-Amino-2,6-lutidine;2,6-dimethylpyridin-4-amine;2,6-dimethyl-4-aminopyridin;2,6-diMethyl-4-PyridinaMine;4-Amino-2,6-dimethylpyridine;6-DIMETHYL-PYRIDIN-4-YLAMINE;4-PyridinaMine, 2,6-diMethyl-;(2,6-dimethyl-4-pyridyl)amine;2,6-DIMETHYL-PYRIDIN-4-YLAMINE
CBNumber: CB8492861
Molecular Formula: C7H10N2
Formula Weight: 122.17
MOL File: 3512-80-9.mol

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2,6-DIMETHYL-PYRIDIN-4-YLAMINE Property

Melting point:: 191.0 to 195.0 °C
Boiling point:: 246°C(lit.)
Density: 1.0289 (estimate)
refractive index: 1.5663 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 10.30±0.50(Predicted)
form: Solid
color: White to Light yellow
Water Solubility: Slightly soluble in water.
λmax: 262nm(MeOH)(lit.)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37/39
RIDADR: UN2811
HazardClass: 6.1
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS019979
Product name: 4-Amino-2,6-dimethylpyridine
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 100 mg
Price: $73.1
Updated: 2025/07/31

TCI Chemical

Product number: A2749
Product name: 4-Amino-2,6-dimethylpyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $105
Updated: 2025/07/31

TCI Chemical

Product number: A2749
Product name: 4-Amino-2,6-dimethylpyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $417
Updated: 2025/07/31

TRC

Product number: D495720
Product name: 2,6-Dimethylpyridin-4-amine
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA64759
Product name: 4-Amino-2,6-dimethylpyridine
Packaging: 1g
Price: $50
Updated: 2021/12/16

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2,6-DIMETHYL-PYRIDIN-4-YLAMINE Chemical Properties,Usage,Production

Chemical Properties

White to off-white solid

Uses

4-Amino-2,6-dimethylpyridine, is an important raw material and intermediate used in pharmaceuticals, agrochemicals, dyestuff, field.

Synthesis

4808-64-4

3512-80-9

The general procedure for the synthesis of 2,6-dimethyl-4-aminopyridine from 2,6-dimethyl-4-nitropyridine 1-oxide was as follows: 4-nitro-2,6-dimethylpyridine-N-oxide (11.0 g, 65.4 mmol) was dissolved in 50 mL of acetic acid, and powdered iron (21.8 g, 390 mmol) was added in batches, while stirring rapidly and heating gradually to 50 °C (note: the reaction becomes exothermic at this temperature). After the exotherm ceased, heating was continued at 80 °C for 1 hour. Upon completion of the reaction, 50 mL of water was added to treat the cured mixture and the suspension was filtered through diatomaceous earth. The filtrate was adjusted to pH > 12 with about 200 mL of 6N sodium hydroxide solution to form a green suspension. The suspension was extracted with chloroform (3 x 300 mL), the organic phases were combined, dried with magnesium sulfate, filtered and concentrated under reduced pressure to give pale yellow crystals (5.70 g, 71% yield). Subsequently, 2,6-dimethylpyridin-4-ylamine (2.00 g, 16.4 mmol) was dissolved in 5 mL of acetic acid, and a 2N acetic acid solution of bromine (0.84 mL, 16.3 mmol) was added dropwise, and the reaction was carried out in a room-temperature water bath for 10 min. after 1 hr, the reaction mixture was treated with 40 mL of a 20% sodium hydroxide solution, and was extracted with dichloromethane (3 × 100 mL) Extraction. The organic phases were combined, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The resulting solid (containing starting material, target product and dibromo by-product in the ratio of 1:3:1) was dissolved in 100 mL of hot hexane and the insoluble material was removed by hot filtration. The filtrate was cooled to room temperature and the title product was precipitated as fine white needle-like crystals (1.30 g, 40% yield).

References

[1] Journal of Heterocyclic Chemistry, 1997, vol. 34, # 3, p. 717 - 727
[2] Patent: WO2005/30213, 2005, A1. Location in patent: Page/Page column 166-167
[3] Organometallics, 2014, vol. 33, # 24, p. 7209 - 7214
[4] Acta Poloniae Pharmaceutica, 1955, vol. 12, p. 105,109
[5] Chem.Abstr., 1956, p. 3427

2,6-DIMETHYL-PYRIDIN-4-YLAMINE Preparation Products And Raw materials

Raw materials

4-Hydroxy-2,6-dimethylpyridine Ethanol Hydrogen peroxide 3-Chloroperoxybenzoic acid Potassium carbonate Palladium 2,6-Lutidine Kieserite Hydrochloric acid Nitric acid Dichloromethane Acetic acid Iron Sulfuric acid

Preparation Products

4-BROMO-PYRIDINE-2,6-DICARBOXYLIC ACID DIAMIDE Chelidamic acid 4-Hydroxy-2,6-dimethylpyridine DIETHYL 4-BROMOPYRIDINE-2,6-DICARBOXYLATE 4-Bromo-2,6-diaminopyridine 4-BROMO-2,6-DIAMINOPYRIDINE

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View Lastest Price from 2,6-DIMETHYL-PYRIDIN-4-YLAMINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,6-DIMETHYL-PYRIDIN-4-YLAMINE 3512-80-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-07

Shaanxi Dideu Medichem Co. Ltd

Product: 2,6-Dimethyl-pyridin-4-ylamine 3512-80-9
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-12

Career Henan Chemical Co

Product: 2,6-DIMETHYL-PYRIDIN-4-YLAMINE 3512-80-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-21

3512-80-9, 2,6-DIMETHYL-PYRIDIN-4-YLAMINERelated Search:

2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-amine hydrochloride hydrate (1:1:1) 2,6-DIMETHYL-PYRIDIN-4-YLAMINE Elbanizine 3-Amino-4,6-dimethylpyridine NIXYLIC ACID 2-BROMO-4,6-DIMETHYL-PYRIDIN-3-YLAMINE 5,6-Dimethylpyridin-2-amine 3,5-DIMETHYLPYRIDIN-4-AMINE 3-Amino-2,4-dimethylpyridine 2,6-DIMETHYL-PYRIDIN-3-YLAMINE 3-Amino-2,6-dimethylpyridine 4,6-DIMETHYL-PYRIDIN-2-YLAMINE 2,3,5,6,7,8-HEXAHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINE 2,6-DIMETHYL-4-NITROPYRIDINE-1-OXIDE 4-AMINO-2-METHYL-5,6,7,8-TETRAHYDROQUINOLINE SALOR-INT L211184-1EA 4,6-DIMETHYL-1,2-DIHYDRO-PYRAZOLO[4,3-C]PYRIDIN-3-ONE 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE

2,6-DIMETHYL-PYRIDIN-4-YLAMINE

2,6-dimethylpyridin-4-amine

4-Amino-2,6-dimethylpyridine

2,6-Dimethyl-pyridin-4-ylamine ,98%

4-Amino-2,6-lutidine

(2,6-dimethyl-4-pyridyl)amine

2,6-dimethyl-4-aminopyridin

4-PyridinaMine, 2,6-diMethyl-

2,6-diMethyl-4-PyridinaMine

2,6-Dimethylpyridin-4-amine, 4-Amino-2,6-lutidine

4-Amino-2,6-dimethylpyridine &gt

-pyridin-4-yL

4-Amino-2,6-dimethylpyridine,98%

2,6-DIMETHYL-PYRIDIN-4-YLAMINE ISO 9001：2015 REACH

6-DIMETHYL-PYRIDIN-4-YLAMINE

2,6-DIMETHYLPYRIDIN-4-AMINE (0.15 KGS)

3512-80-9