4-Hydroxy-2-butanone
- Product Name
- 4-Hydroxy-2-butanone
- CAS No.
- 590-90-9
- Chemical Name
- 4-Hydroxy-2-butanone
- Synonyms
- 4-hydroxybutan-2-one;CH3C(O)CH2CH2OH;Methylolacetone;2-Butanone, 4-hydroxy-;3-Oxobutanol;Butanone glycol;3-Ketobutan-1-ol;H**4-HYDROXY-2-BUTANONE;ketobutanol;3-Oxo-1-butanol
- CBNumber
- CB8493505
- Molecular Formula
- C4H8O2
- Formula Weight
- 88.11
- MOL File
- 590-90-9.mol
4-Hydroxy-2-butanone Property
- Melting point:
- 15°C (estimate)
- Boiling point:
- 73-76 °C/12 mmHg (lit.)
- Density
- 1.023 g/mL at 25 °C (lit.)
- refractive index
- 1.430
- Flash point:
- 91°F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform, Methanol (Slightly)
- form
- Oil
- pka
- 14.43±0.10(Predicted)
- color
- Clear Colourless
- Water Solubility
- Miscible with water, alcohol, ethanol and ether.
- BRN
- 1737666
- InChI
- 1S/C4H8O2/c1-4(6)2-3-5/h5H,2-3H2,1H3
- InChIKey
- LVSQXDHWDCMMRJ-UHFFFAOYSA-N
- SMILES
- CC(=O)CCO
- LogP
- -1.209 at 25℃
- CAS DataBase Reference
- 590-90-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Hydroxy-2-butanone(590-90-9)
- EPA Substance Registry System
- 2-Butanone, 4-hydroxy- (590-90-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 252557
- Product name
- 4-Hydroxy-2-butanone
- Purity
- 95%
- Packaging
- 100g
- Price
- $193
- Updated
- 2026/03/19
- Product number
- H0584
- Product name
- 4-Hydroxy-2-butanone
- Purity
- >95.0%(GC)
- Packaging
- 25mL
- Price
- $34
- Updated
- 2026/03/19
- Product number
- H0584
- Product name
- 4-Hydroxy-2-butanone
- Purity
- >95.0%(GC)
- Packaging
- 100mL
- Price
- $100
- Updated
- 2026/03/19
- Product number
- H0584
- Product name
- 4-Hydroxy-2-butanone
- Purity
- >95.0%(GC)
- Packaging
- 500mL
- Price
- $353
- Updated
- 2026/03/19
- Product number
- H819000
- Product name
- 4-Hydroxy-2-butanone
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
4-Hydroxy-2-butanone Chemical Properties,Usage,Production
Chemical Properties
Colourless to pale yellow liquid
Uses
4-Hydroxy-2-butanone is used in the preparation of fused benzazepine molecules as selective D3 receptor antagonists with pharmaceutical activity. It is also used in the preparation of verrucarin and mevalonic acid lactone. Further, it is used to prepare 3-buten-2-one through dehydration over an anatase titanium dioxide catalyst. It is also employed in the preparation of 4-methyl-5-hydroxymethylthiazole, (±)-lineatin and beta-hydroxylactones.
Application
4-Hydroxy-2-butanone has been used in the synthesis of:
- 3-buten-2-one via dehydration over anatase-TiO2 catalyst
- 4-methyl-5-hydroxymethylthiazole
- (±)-lineatin
- mevalonic acid lactone
- verrucarin
- β-hydroxylactones
Definition
ChEBI: A beta-hydroxy ketone that is butan-2-one substituted by a hydroxy group at position 4.
General Description
4-Hydroxy-2-butanone is an important pharmaceutical intermediate. Gas phase reaction of the OH radicals with 4-hydroxy-2-butanone has been investigated by absolute rate method.
Synthesis
A method for synthesizing 4-hydroxy-2-butanone, comprising the steps of:
(1) adding a certain amount of 1.3 butanediol, catalyst, water and water-carrying agent to a reaction vessel, stirring well to form a mixed solution, and raising temperature to 60-75C;
(2) continue stirring, add hydrogen peroxide with a mass concentration of 25-35% dropwise to the mixed solution, and distill and dehydrate while dropping and adding;
(3) When the content of 1.3 butanediol in the reaction vessel is detected to be less than 5% of the initial content, stop adding hydrogen peroxide dropwise, and continue stirring for 0.5-1.5h;
(4) control the temperature in the reaction vessel, and vaporize the water-carrying agent;
(5) lowering the temperature in the reaction vessel to 60-65C and distilling to obtain the target product 4-hydroxy-2-butanone.
4-Hydroxy-2-butanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Hydroxy-2-butanone manufacturers
- Product
- 4-Hydroxy-2-butanone 590-90-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-20
- Product
- 4-Hydroxy-2-butanone 590-90-9
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- 4-Hydroxy-2-butanone 590-90-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 95%+
- Supply Ability
- 30MT/Month
- Release date
- 2023-01-30