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SOPHORIDINE

Product Name
SOPHORIDINE
CAS No.
6882-68-4
Chemical Name
SOPHORIDINE
Synonyms
OPHORIDINE;Sophoridin;Sordidness;Sophoridine;l-sophoridine;I-SOPHORIDINE;(-)-Sophoridine;Sophoridine Powder;(5β)-Matridin-15-one;Matridin-15-one,(5β)-
CBNumber
CB8495448
Molecular Formula
C15H24N2O
Formula Weight
248.36
MOL File
6882-68-4.mol
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SOPHORIDINE Property

Melting point:
109-110 °C
Boiling point:
396.7±31.0 °C(Predicted)
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in ethanol, methanol and water
form 
powder to crystal
pka
9.47±0.20(Predicted)
color 
White to Light yellow
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Safety

Safety Statements 
24/25
HS Code 
29399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL80540
Product name
Sophoridine
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$342
Updated
2024/03/01
TCI Chemical
Product number
M3093
Product name
Sophoridine
Packaging
50MG
Price
$73
Updated
2024/03/01
TCI Chemical
Product number
M3093
Product name
Sophoridine
Packaging
250MG
Price
$219
Updated
2024/03/01
TRC
Product number
S676840
Product name
(-)Sophoridine
Packaging
100mg
Price
$120
Updated
2021/12/16
ApexBio Technology
Product number
N2782
Product name
Sophoridine
Packaging
20mg
Price
$50
Updated
2021/12/16
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SOPHORIDINE Chemical Properties,Usage,Production

Description

Sophoridine is a quinolizidine alkaloid isolated from traditional Chinese herbs, which exists in the stems and leafs of Leguminous plant Sophora alopecuroides L., Euchresta japonica Benth., and the roots of Sophora alopecuroides Ait. Sophoridine-induced synchronous oscillations in the hippocampus could elicit the generation and development of seizure. Accumulating evidence demonstrates remarkable pharmacological effects of Sophoridine, including anti-inflammatory, anti-virus and anti-cancer effects.

Uses

(-)Sophoridine is an anticancer agent, with a promising anti-rumor effect and lower toxicity. Anti-inflammatory.

Definition

Sophoridine is a quinolizidine alkaloid isolated from leafs of Leguminous plant Sophora alopecuroides.L. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor drug candidate for pancreatic cancer with well-tolerated toxicity.

General Description

Sophoridine, a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1.

Biological Activity

Sophoridine is promising to be a novel, potent and selective antitumor drug candidate for pancreatic cancer. It was shown that sophoridine is able to suppress hepatocellular carcinoma in vitro and vivo. Sophoridine dose- and time-dependently blocks the RANKL-induced osteoclasts formation and the activation of ERK and c-Fos as well as the induction and nucleus translocation of NFATc1.

Mechanism of action

Sophoridine is an active quinolizidine alkaloid isolated from leaves of Leguminous plant Sophora alopecuroides. L. Accumulating evidence demonstrated that Sophoridine displays remarkable pharmacological effects in inflammatory diseases , infectious diseases and cancers . In particular, Sophoridine and its derivatives have drawn more and more attention owing to their potent anti-tumor effects in different tumor cell lines and animal models. The underlying anti-tumor mechanisms of Sophoridine including increase of intracellular ROS levels, activation of the phosphorylation of ERK and JNK, induction of S phase arrest in pancreatic cancer cells; inhibition of growth and invasion in human colorectal cancer cells via directly binding to MAPKAPK2 and inactivates its phosphorylation; inhibition of ubiquitin-proteasome pathway in human glioma cells.

in vitro

Sophoridine (0-500 μM; 48 hours) exhibits remarkable inhibition effects to the growth of human pancreatic, gastric, liver, colon, gallbladder, and prostate carcinoma cells with IC50 values of about 20 μM to 200 μM.Sophoridine (0-20 μM; 48 hours) increases S phase cell population from 26.23% (control) to 38.67% in Miapaca-2 cells and from 29.56% (control) to 39.16% in PANC-1 cells, about a 1.5-fold and a 1.3-fold increase, respectively.Sophoridine (0-20 μM; 48 hours) significantly increases bad and bax levels, and decreases bcl-2 and bcl-xl levels in contrast, with a significant increase in Bax/Bcl-2 ratio.

Source

Sophoridine is a bioactive alkaloid found in many Chinese herbs, such as Sophora alopecuroides l, Euchresta japonica Benth and Sophora moocrorftinan. Sophoridine hydrochloride injection has been approved as an anticancer drug in China.

SOPHORIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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SOPHORIDINE Suppliers

Americas 1 China 159 Europe 2 Germany 1 India 2 Japan 1 Ukraine 1 United Kingdom 4 United States 21 Global 192
EMMX Biotechnology LLC
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View Lastest Price from SOPHORIDINE manufacturers

Hebei Kingfiner Technology Development Co.Ltd
Product
SOPHORIDINE 6882-68-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2024-05-28
Shaanxi Haibo Biotechnology Co., Ltd
Product
Sophoridine Powder 6882-68-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
5000kg/Month
Release date
2023-08-28
Shanghai Standard Technology Co., Ltd.
Product
Sophoridine 6882-68-4
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-10

6882-68-4, SOPHORIDINERelated Search:

Sophoridine Atropine Sophocarpine 13,14-Didehydromatridin-15-one Matrine phellodendrine CHELIDONINE Lycorine hydrochloride Sophoricoside 1-Acetylpiperidin-4-amine 1-(PIPERIDIN-3-YLMETHYL)PIPERIDINE 1-ACETYL-3-METHYLPIPERIDINE N,N-DIBUTYL-1,3-PROPANEDIAMINE SOPHORIDINE 1-(3-AMINOPROPYL)-2-PIPECOLINE N,N-DIMETHYL-3-PIPERIDINEMETHANAMINE 1-Acetyl-4-(methylamino)piperidine 3-(2-ethylpiperidin-1-yl)propan-1-amine

  • Sophoridine
  • (5-beta)-Matridin-15-one
  • Matridin-15-one, (5-beta)- (9ci)
  • Sophoridin
  • SOLSTITIALIN A 13-ACETATE(SH)(CALL)
  • OPHORIDINE
  • Sophoridine, 98%, from Sophora alopecuroides L.
  • 5-EPIDIHYDROSOPHOCARPINE
  • (5-beta)-matridin-15-on
  • l-sophoridine
  • DIHYDRO-5-EPISOPHOCARPINE
  • I-SOPHORIDINE
  • Matridin-15-one,(5β)-
  • (5β)-Matridin-15-one
  • 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aR,13aR,13bR,13cS)-
  • (7aR,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
  • SOPHORIDINE USP/EP/BP
  • Sordidness
  • (-)-Sophoridine
  • (41S,7aR,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one
  • Sophoridine Powder
  • (41S,7aR,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-one
  • Docusate Sodium Impurity 10
  • 6882-68-4
  • Alkaloids
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract