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Lycorine hydrochloride

Product Name
Lycorine hydrochloride
CAS No.
2188-68-3
Chemical Name
Lycorine hydrochloride
Synonyms
LYCORIN;LYCORINE;(-)-LYCORINE;NARCISSIN(P);Lycorine chloride;Hydrochloric Lycorine;Licorin hydrochloride;Lycorine hydrochloride;Licorine hydrochloride;Amarylline hydrochloride
CBNumber
CB6415905
Molecular Formula
C16H17NO4
Formula Weight
287.31
MOL File
2188-68-3.mol
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Lycorine hydrochloride Property

Melting point:
206 °C
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in water (15 mg/ml)
form 
powder
color 
White to off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L5139
Product name
Lycorine hydrochloride
Purity
≥98% (TLC), powder
Packaging
20mg
Price
$360
Updated
2024/03/01
TRC
Product number
L487550
Product name
Lycorine hydrochloride
Packaging
20mg
Price
$110
Updated
2021/12/16
TRC
Product number
L487550
Product name
Lycorine hydrochloride
Packaging
50mg
Price
$150
Updated
2021/12/16
Usbiological
Product number
300599
Product name
Lycorine hydrochloride
Packaging
20mg
Price
$263
Updated
2021/12/16
ChemScene
Product number
CS-5954
Product name
Lycorine hydrochloride
Purity
99.89%
Packaging
100mg
Price
$264
Updated
2021/12/16
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Lycorine hydrochloride Chemical Properties,Usage,Production

Description

Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4?A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5

Uses

Lycorine Hydrochloride is the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.

Biochem/physiol Actions

A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.

References

Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; Nat. Prod., 68 168 Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483 Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407 Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174 Zheng et al. (2020), The Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1

Lycorine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Lycorine hydrochloride Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
Advantage
61
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777;
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17840
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8850
Advantage
52
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18736
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4531
Advantage
62
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4648
Advantage
58
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View Lastest Price from Lycorine hydrochloride manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.
Product
Lycorine hydrochloride 2188-68-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
1000KG
Release date
2022-09-22
Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
Lycorine hydrochloride 2188-68-3
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
≥98%
Supply Ability
20tons
Release date
2024-01-04
Baoji Guokang Bio-Technology Co., Ltd.
Product
Lycorine hydrochloride 2188-68-3
Price
US $3175.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1000kg
Release date
2021-06-02

2188-68-3, Lycorine hydrochlorideRelated Search:


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