ChemicalBook > CAS DataBase List > Lycorine hydrochloride

Lycorine hydrochloride

Product Name: Lycorine hydrochloride
CAS No.: 2188-68-3
Chemical Name: Lycorine hydrochloride
Synonyms: LYCORIN;LYCORINE;(-)-LYCORINE;NARCISSIN(P);Lycorine chloride;Hydrochloric Lycorine;Licorin hydrochloride;Lycorine hydrochloride;Licorine hydrochloride;Amarylline hydrochloride
CBNumber: CB6415905
Molecular Formula: C16H17NO4
Formula Weight: 287.31
MOL File: 2188-68-3.mol

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Lycorine hydrochloride Property

Melting point:: 206 °C
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Soluble in water (15 mg/ml)
form: powder
color: White to off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L5139
Product name: Lycorine hydrochloride
Purity: ≥98% (TLC), powder
Packaging: 20mg
Price: $371
Updated: 2025/07/31

TRC

Product number: L487550
Product name: Lycorine hydrochloride
Packaging: 20mg
Price: $110
Updated: 2021/12/16

TRC

Product number: L487550
Product name: Lycorine hydrochloride
Packaging: 50mg
Price: $150
Updated: 2021/12/16

Usbiological

Product number: 300599
Product name: Lycorine hydrochloride
Packaging: 20mg
Price: $263
Updated: 2021/12/16

ApexBio Technology

Product number: N1555
Product name: Lycorinechloride
Packaging: 20mg
Price: $50
Updated: 2021/12/16

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Lycorine hydrochloride Chemical Properties,Usage,Production

Description

Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4?A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Lycoris radiata bulbs.

Uses

Lycorine Hydrochloride is the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.

Biochem/physiol Actions

A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.

in vivo

Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry^[1].

Animal Model:	6- to 8-week-old BALB/C nude mice^[1]
Dosage:	0 μg, 7.5 μg, 15 μg
Administration:	Subcutaneous injection; for 14 days
Result:	Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.

References

[1] GIEDRIUS MILIAUSKAS. Identification of Radical Scavenging Compounds in Rhaponticum carthamoides by Means of LC-DAD-SPE-NMR[J]. Journal of Natural Products , 2005, 68 2: 168-172. DOI:10.1021/np0496901
[2] JIANGNING LIU. Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication.[J]. Virology Journal, 2011: 483. DOI:10.1186/1743-422x-8-483
[3] YOSHIAKI ONISHI Y Y Yasuhiro Kawano. Lycorine, a candidate for the control of period length in mammalian cells.[J]. Cellular Physiology and Biochemistry, 2012, 29 3-4: 407-416. DOI:10.1159/000338495
[4] ZHIFEI CAO . Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity[J]. Toxicology letters, 2013, 218 2: Pages 174-185. DOI:10.1016/j.toxlet.2013.01.018
[5] LIANGDE ZHENG. The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy.[J]. Autophagy, 2019. DOI:10.1080/15548627.2019.1668228

Lycorine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Lycorine hydrochloride manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Lycorine hydrochloride 2188-68-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 1000KG
Release date: 2022-09-22

BINBO BIOLOGICAL CO.,LTD

Product: Lycorine hydrochloride 2188-68-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000 kg
Release date: 2024-04-29

Baoji Guokang Healthchem Co., Ltd.

Product: Lycorine hydrochloride 2188-68-3
Price: US $3175.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000kg
Release date: 2021-06-02

2188-68-3, Lycorine hydrochlorideRelated Search:

Cetirizine dihydrochloride Topotecan hydrochloride 1-AdaMantanethylaMine Diphenhydramine Hydrochloride Sultopride hydrochloride Coptisine chloride CUCURBITACIN IIA Evodiamine Isorhamnetin Rhamnetin Sibutramine hydrochloride Tramadol hydrochloride LYCORINE HYDROCHLORIDE,LYCORINE HPLC 98+%,LYCORINE,(-)-LYCORINE,LYCORINE HCL LYCORINE HBR Lycorine hydrochloride Lycorine O1,O2-di-(β-D-glucopyranoside) AKOS 244-36 LYCORINE HYDROBROMIDE

Lycorine Hydrochloride98%

Licorin hydrochloride

Hydrochloric Lycorine

LYCORIN

(-)-LYCORINE

LYCORINE

1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol,2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)-

NARCISSIN(P)

(1S,2S,12BS,12CS)-1,2,4,5,12B,12C-HEXAHYDRO-7H-[1,3]DIOXOLO[4,5-J]PYRROLO[3,2,1-DE]PHENANTHRIDINE-1,2-DIOL

Lycorine hydrochloride

Lycorine chloride

Lycorinehydrochloride 2188-68-3

Lycorine chloride 2188-68-3

Lycorine hydrochloride, 96%(HPLC)

Amarylline hydrochloride

Galanthidine hydrochloride

Licorine hydrochloride

Narcissine hydrochloride

Lycorine hydrochloride USP/EP/BP

(1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride

(1S,2S,12bS,12cS)-2,4,5,7,12b,12c-hexahydro-1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride (1:1)

(1R,17S,18R,19S)-5,7-Dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol

Lycorine hydrochloride 98%

(1S,2S,12bS,12cS)-2,4,5,7,12b,12C-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol HCl

2188-68-3

C16H17NO4HCl

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Gene Regulation and Expression

RNA-Protein Translation Inhibitors

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Peptidyl transferaseCell Signaling and Neuroscience

Enzyme Inhibitors by Enzyme

Gene Regulation and Expression

P to

RNA-Protein Translation Inhibitors