Lycorine hydrochloride
- Product Name
- Lycorine hydrochloride
- CAS No.
- 2188-68-3
- Chemical Name
- Lycorine hydrochloride
- Synonyms
- LYCORIN;LYCORINE;(-)-LYCORINE;NARCISSIN(P);Lycorine chloride;Hydrochloric Lycorine;Licorin hydrochloride;Lycorine hydrochloride;Licorine hydrochloride;Amarylline hydrochloride
- CBNumber
- CB6415905
- Molecular Formula
- C16H17NO4
- Formula Weight
- 287.31
- MOL File
- 2188-68-3.mol
Lycorine hydrochloride Property
- Melting point:
- 206 °C
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Soluble in water (15 mg/ml)
- form
- powder
- color
- White to off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- L5139
- Product name
- Lycorine hydrochloride
- Purity
- ≥98% (TLC), powder
- Packaging
- 20mg
- Price
- $360
- Updated
- 2024/03/01
- Product number
- L487550
- Product name
- Lycorine hydrochloride
- Packaging
- 20mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- L487550
- Product name
- Lycorine hydrochloride
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 300599
- Product name
- Lycorine hydrochloride
- Packaging
- 20mg
- Price
- $263
- Updated
- 2021/12/16
- Product number
- CS-5954
- Product name
- Lycorine hydrochloride
- Purity
- 99.89%
- Packaging
- 100mg
- Price
- $264
- Updated
- 2021/12/16
Lycorine hydrochloride Chemical Properties,Usage,Production
Description
Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4?A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5
Uses
Lycorine Hydrochloride is the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.
Biochem/physiol Actions
A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.
References
Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; Nat. Prod., 68 168 Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483 Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407 Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174 Zheng et al. (2020), The Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1
Lycorine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Lycorine hydrochloride Suppliers
View Lastest Price from Lycorine hydrochloride manufacturers
- Product
- Lycorine hydrochloride 2188-68-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-09-22
- Product
- Lycorine hydrochloride 2188-68-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- ≥98%
- Supply Ability
- 20tons
- Release date
- 2024-01-04
- Product
- Lycorine hydrochloride 2188-68-3
- Price
- US $3175.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2021-06-02