Lycorine hydrochloride
- Product Name
- Lycorine hydrochloride
- CAS No.
- 2188-68-3
- Chemical Name
- Lycorine hydrochloride
- Synonyms
- LYCORIN;LYCORINE;(-)-LYCORINE;NARCISSIN(P);Lycorine chloride;Hydrochloric Lycorine;Licorin hydrochloride;Lycorine hydrochloride;Licorine hydrochloride;Amarylline hydrochloride
- CBNumber
- CB6415905
- Molecular Formula
- C16H17NO4
- Formula Weight
- 287.31
- MOL File
- 2188-68-3.mol
Lycorine hydrochloride Property
- Melting point:
- 206 °C
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Soluble in water (15 mg/ml)
- form
- powder
- color
- White to off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- L5139
- Product name
- Lycorine hydrochloride
- Purity
- ≥98% (TLC), powder
- Packaging
- 20mg
- Price
- $371
- Updated
- 2025/07/31
- Product number
- L487550
- Product name
- Lycorine hydrochloride
- Packaging
- 20mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- L487550
- Product name
- Lycorine hydrochloride
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 300599
- Product name
- Lycorine hydrochloride
- Packaging
- 20mg
- Price
- $263
- Updated
- 2021/12/16
- Product number
- CS-5954
- Product name
- Lycorine hydrochloride
- Purity
- 99.89%
- Packaging
- 100mg
- Price
- $264
- Updated
- 2021/12/16
Lycorine hydrochloride Chemical Properties,Usage,Production
Description
Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4?A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Lycoris radiata bulbs.
Uses
Lycorine Hydrochloride is the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.
Biochem/physiol Actions
A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.
in vivo
Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry[1].
| Animal Model: | 6- to 8-week-old BALB/C nude mice[1] |
| Dosage: | 0 μg, 7.5 μg, 15 μg |
| Administration: | Subcutaneous injection; for 14 days |
| Result: | Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry. |
References
[1] GIEDRIUS MILIAUSKAS. Identification of Radical Scavenging Compounds in Rhaponticum carthamoides by Means of LC-DAD-SPE-NMR[J]. Journal of Natural Products , 2005, 68 2: 168-172. DOI:10.1021/np0496901
[2] JIANGNING LIU. Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication.[J]. Virology Journal, 2011: 483. DOI:10.1186/1743-422x-8-483
[3] YOSHIAKI ONISHI Y Y Yasuhiro Kawano. Lycorine, a candidate for the control of period length in mammalian cells.[J]. Cellular Physiology and Biochemistry, 2012, 29 3-4: 407-416. DOI:10.1159/000338495
[4] ZHIFEI CAO . Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity[J]. Toxicology letters, 2013, 218 2: Pages 174-185. DOI:10.1016/j.toxlet.2013.01.018
[5] LIANGDE ZHENG. The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy.[J]. Autophagy, 2019. DOI:10.1080/15548627.2019.1668228
Lycorine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Lycorine hydrochloride Suppliers
- Tel
- --
- Fax
- --
- latoxan@latoxan.com
- Country
- France
- ProdList
- 336
- Advantage
- 68
View Lastest Price from Lycorine hydrochloride manufacturers
- Product
- Lycorine hydrochloride 2188-68-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-09-22
- Product
- Lycorine hydrochloride 2188-68-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-29
- Product
- Lycorine hydrochloride 2188-68-3
- Price
- US $3175.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2021-06-02