Tocainide hydrochloride
- Product Name
- Tocainide hydrochloride
- CAS No.
- 35891-93-1
- Chemical Name
- Tocainide hydrochloride
- Synonyms
- Xylotocan;TOCAINIDE HCL;Unii-2K7I38ckn5;tonocardhydrochloride;tocainide hydrochloride;TOCAINIDE HYDROCHLORIDE (125 MG);Tocainide hydrochloride USP/EP/BP;Tocainide Hydrochloride (1667552);2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride;2-amino-n-(2,6-dimethylphenyl)-propanamidmonohydrochloride
- CBNumber
- CB8500546
- Molecular Formula
- C11H17ClN2O
- Formula Weight
- 228.71848
- MOL File
- 35891-93-1.mol
Tocainide hydrochloride Property
- Melting point:
- 244-245°C
- storage temp.
- -20°C Freezer
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- Off-White
Safety
- HS Code
- 2924296000
N-Bromosuccinimide Price
- Product number
- T525453
- Product name
- Tocainide hydrochloride
- Packaging
- 1.25mg
- Price
- $45
- Updated
- 2021/12/16
Tocainide hydrochloride Chemical Properties,Usage,Production
Uses
Tonocard(AstraZeneca).
Uses
Tocainide Hydrochloride is used as an anti-arrythmic drug as myocardial depressants.
General Description
Tocainide hydrochloride,2-amino-2＇ ,6 ＇-propionoxyxylidide hydrochloride (Tonocard)(pKa 7.7), is an analog of lidocaine. It is orally active and haselectrophysiological properties like those of lidocaine. Totalbody clearance of tocainide hydrochloride is only166 mL/min, suggesting that hepatic clearance is not large.Because of low hepatic clearance, the hepatic extraction ratiomust be small; therefore, tocainide hydrochloride is unlikelyto be subject to a substantial first-pass effect. The drug differsfrom lidocaine, in that it lacks two ethyl groups, which providestocainide hydrochloride some protection from first-passhepatic elimination after oral ingestion. Tocainide hydrochlorideis hydrolyzed in a manner similar to that of lidocaine.None of its metabolites is active.
Clinical Use
Tocainide hydrochloride is classed as a IB antiarrhythmicagent and used orally to prevent or treat ventricular ectopyand tachycardia. The drug is given in 400- to 600-mgdoses every 8 hours.
Veterinary Drugs and Treatments
Veterinary experience with tocainide is limited. At this time, dogs are the only veterinary species where enough clinical experience has been garnered to recommend its use. It is indicated for the oral therapy of ventricular arrhythmias, principally ventricular tachycardia and ventricular premature complexes. In humans, response to lidocaine can usually predict whether tocainide might be effective.
Tocainide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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