VX-745

ChemicalBook > CAS DataBase List > VX-745

Product Name: VX-745
CAS No.: 209410-46-8
Chemical Name: VX-745
Synonyms: CS-1918;VD31745;VX-745, >=96%;VX-745(VX 745);VX-745 (Free base);NEFLAMAPIMOD;VX 745;Naluzotan Hydrochloride;Neflamapimod, 10 mM in DMSO;Neflamapimod (VX745, VRT031745;VX-745, p38 alpha MAPK inhibitor
CBNumber: CB8511364
Molecular Formula: C19H9Cl2F2N3OS
Formula Weight: 436.26
MOL File: 209410-46-8.mol

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VX-745 Property

Melting point:: 261-264 °C
Boiling point:: 578.9±60.0 °C(Predicted)
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: ≥21.8 mg/mL in DMSO; insoluble in H2O; ≥2.1 mg/mL in EtOH with gentle warming and ultrasonic
form: powder
pka: -0.97±0.40(Predicted)
color: white to beige

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1638
Product name: VX-745
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $108
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1638
Product name: VX-745
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $435
Updated: 2024/03/01

Cayman Chemical

Product number: 18075
Product name: VX-745
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18075
Product name: VX-745
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 18075
Product name: VX-745
Purity: ≥98%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

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VX-745 Chemical Properties,Usage,Production

Description

VX-745 is an inhibitor of p38α MAPK (IC₅₀ = 9 nM). It is selective for p38α over p38β MAPK (K_i = 220 nM) as well as ERK, JNK, and a panel of 50 kinases when used at a concentration of 2 μM. VX-745 inhibits LPS-induced production of IL-1β and TNF-α in isolated human peripheral blood mononuclear cells (PBMCs; IC₅₀s = 45 and 51 nM, respectively). It reduces disease severity in a type II collagen-induced mouse model of arthritis when administered at a dose of 10 mg/kg.

Chemical Properties

Pale Yellow Solid

Uses

VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.

Definition

ChEBI: A member of the class of pyrimidopyridazines that is 6H-pyrimido[1,6-b]pyridazin-6-one substituted at positions 2 and 5 by (2,4-difluorophenyl)sulfanyl and 2,6-dichlorophenyl groups respectively

Biochem/physiol Actions

VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα. VX-745 showed 20-fold selectivity for p38α over p38β and a Ki value of 220 nM. VX-745 has been shown to reduce inflammation in an arthritic (AIA) mouse model and to improve performance in aged rats.

storage

-20°C

References

[1]. bagley, m.c., et al., microwave-assisted ullmann c-s bond formation: synthesis of the p38alpha mapk clinical candidate vx-745. j org chem, 2009. 74(21): p. 8336-42.
[2]. dent, p., et al., mapk pathways in radiation responses. oncogene, 2003. 22(37): p. 5885-96.
[3]. dominguez, c., d.a. powers, and n. tamayo, p38 map kinase inhibitors: many are made, but few are chosen. curr opin drug discov devel, 2005. 8(4): p. 421-30.
[4]. duffy, j.p., et al., the discovery of vx-745: a novel and selective p38alpha kinase inhibitor. acs med chem lett, 2011. 2(10): p. 758-63.
[5]. bagley, m.c., et al., gram-scale synthesis of the p38alpha mapk-inhibitor vx-745 for preclinical studies into werner syndrome. future med chem, 2010. 2(9): p. 1417-27.

VX-745 Preparation Products And Raw materials

Raw materials

Preparation Products

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209410-46-8, VX-745Related Search:

Sulfadiazine Dichlorodiphenylsilane Dichloromethylphenylsilane Dichloroethane Sodium dichloroisocyanurate Triphenylphosphine Thionyl chloride Quinclorac Telaprevir Tozasertib Lumacaftor (VX-809) VX 702 Tofacitinib citrate Enzalutamide Quizartinib (AC220) SGX-523 1H-Pyrrole-2-carboxaMide, 4-[2-[(2-chloro-4-fluorophenyl)aMino]-5-Methyl-4-pyriMidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]- Pictilisib

6H-PYRIMIDO[1,6-B]PYRIDAZIN-6-ONE, 5-(2,6-DICHLOROPHENYL)-2-[(2,4-DIFLUOROPHENYL)THIO]- (9CI)

6H-PYRIMIDO[1,6-B]PYRIDAZIN-6-ONE, 5-(2,6-DICHLOROPHENYL)-2-[(2,4-DIFLUOROPHENYL)THIO]-

5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-on

5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one

CS-1918

5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one

5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one

5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylsulfanyl)-6H-pyriMido[3,4-b]pyridazin-6-one

VX-745(VX 745)

5-(2,6-Dichloro-phenyl)-2-(2,4-difluoro-phenylsulfanyl)-1,7,8a-triaza-naphthalen-6-one

5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one VX-745

VX-745 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one

VX-745, >=96%

VX-745 (Free base)

Naluzotan Hydrochloride

NEFLAMAPIMOD;VX 745

Neflamapimod (VX745, VRT031745

VD31745

Neflamapimod VX-745 MAPK inhibitor

Inhibitor,VX745,Neflamapimod,Autophagy,VX 745,inhibit,p38 MAPK

5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one

VX-745, p38 alpha MAPK inhibitor

Neflamapimod, 10 mM in DMSO

209410-46-8

C19H9Cl2F2N3OS

MAPK

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds