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LY3143921

Product Name
LY3143921
CAS No.
1627696-53-0
Chemical Name
LY3143921
Synonyms
LY3143921;LY3143921 hydrate;LY3143921 hydrate ，S9650;LY-3143921 hydrate,LY3143921 hydrate
CBNumber
CB85867383
Molecular Formula
C16H14FN5O2
Formula Weight
327.32
MOL File
1627696-53-0.mol
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LY3143921 Property

storage temp. 
Store at -20°C
solubility 
DMSO: 65 mg/mL (198.59 mM);Ethanol: 32 mg/mL (97.77 mM)
form 
Solid
color 
White to off-white
Water Solubility 
Water: Insoluble
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Hazard and Precautionary Statements (GHS)

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LY3143921 Chemical Properties,Usage,Production

Uses

LY3177833 (Example 4) monhydrate is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 monhydrate is a senescence inducer[1][2].

Biological Activity

LY3143921 hydrate is an orally administered ATP-competitive CDC7 inhibitor.

in vivo

LY3177833 (Example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation[1].

Animal Model:Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells[1]
Dosage:10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg
Administration:Oral gavage; twice a day for 2 weeks
Result:Showed dose dependent antitumor activity in SW620 mouse xenograft tumor model.

IC 50

Cdc7: 3.3 nM (IC50); pMCM2: 290 nM (IC50)

References

[1] Peter F. Gallagher, et al. Journal of Clinical Oncology. Volume 37, Issue 15_suppl.

LY3143921 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY3143921 Suppliers

China 16 United States 3 Global 19
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
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China
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4720
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
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58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
2998
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
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China
ProdList
11973
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58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29995
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58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
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China
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12000
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RD International Technology Co., Limited
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18024082417
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market@ubiochem.com
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China
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9835
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58
Sangon Biotech (Shanghai) Co.,Ltd.
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400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
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58
Biosynth Biological Technology (Suzhou) Co Ltd
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51288865780
Email
sales@biosynth.com
Country
China
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6051
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58
Selleck Chemicals
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400-668-6834
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info@selleck.cn
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China
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6071
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Nantong HI-FUTURE Biology Co., Ltd.
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+undefined18051384581
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sales@chemhifuture.com
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China
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Chongqing Aoyi Biotechnology Co., Ltd.
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13102311730,18585291730
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CHINA
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140
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Guangzhou Kegou Biotechnology Co., Ltd.
Tel
18689410811
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CHINA
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178
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Absin Bioscience Inc.
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Email
chenjw@absin.cn
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CHINA
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Proteintech China
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Email
Proteintech-CN@ptglab.com
Country
CHINA
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6290
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1627696-53-0, LY3143921Related Search:

LY 294002 Hydrochloride 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE LY-404039 LY 2606368 LY 379268 LY-2940094 LY2109761

  • LY3143921
  • LY3143921 hydrate
  • LY-3143921 hydrate,LY3143921 hydrate
  • LY3143921 hydrate ，S9650
  • 1627696-53-0