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2'-Deoxy-2'-fluorocytidine

Product Name
2'-Deoxy-2'-fluorocytidine
CAS No.
10212-20-1
Chemical Name
2'-Deoxy-2'-fluorocytidine
Synonyms
2'-FC;2'-FdC;RO-8013;2'-F-dC;2'-FANA-C;NSC 529432;2’-F-2’-dC;2'-FLUORO-D-CYTIDINE;2'-Fluoro-d-Cytidine;2'-F-2'-deoxyCytidine
CBNumber
CB8670324
Molecular Formula
C9H12FN3O4
Formula Weight
245.21
MOL File
10212-20-1.mol
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2'-Deoxy-2'-fluorocytidine Property

Melting point:
167 °C
Boiling point:
500.1±60.0 °C(Predicted)
Density 
1.82±0.1 g/cm3(Predicted)
refractive index 
80 ° (C=1, MeOH)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Soluble in DMSO, Methanol.
pka
12.84±0.70(Predicted)
form 
Powder
color 
White to Off-white
Water Solubility 
Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C)
InChI
InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1
InChIKey
NVZFZMCNALTPBY-XVFCMESISA-N
SMILES
OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O
CAS DataBase Reference
10212-20-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D3614
Product name
2'-Deoxy-2'-fluorocytidine Hydrate
Purity
>98.0%(T)
Packaging
1g
Price
$68
Updated
2024/03/01
Alfa Aesar
Product number
J65632
Product name
2'-Fluoro-2'-deoxycytidine, 99%
Packaging
1g
Price
$52.65
Updated
2024/03/01
TRC
Product number
D232945
Product name
2’-Deoxy-2’-fluoroCytidine
Packaging
2g
Price
$145
Updated
2021/12/16
TRC
Product number
D232945
Product name
2’-Deoxy-2’-fluoroCytidine
Packaging
10g
Price
$525
Updated
2021/12/16
AK Scientific
Product number
AMTA037
Product name
2'-Fluoro-2'-deoxycytidine
Packaging
1g
Price
$25
Updated
2021/12/16
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2'-Deoxy-2'-fluorocytidine Chemical Properties,Usage,Production

Description

2'-Deoxy-2'-fluorocytidine is a nucleoside analog. It has antiviral effects and can synergize with T705 to effectively inhibit Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2'-Deoxy-2'-fluorocytidine can also inhibit dihydrofolate reductase, thereby preventing the production of tetrahydrofolate, which is required for the synthesis of purines and pyrimidines. It has a certain inhibitory effect on poliovirus, herpes simplex virus, vesicular stomatitis virus and influenza A virus.

Chemical Properties

White Solid

Uses

2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s pread.

in vitro

2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.

References

[1] Stephen R. Welch. “Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus.” Antiviral research 147 (2017): Pages 91-99.

2'-Deoxy-2'-fluorocytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Deoxy-2'-fluorocytidine Suppliers

Zhejiang Huida Biotech Co., LTD
Tel
0571-0571-89903882 15990081639
Email
sunshixuan@huidabiotech.com
Country
China
ProdList
3705
Advantage
58
Shanghai Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
021-58955996
Email
info@chemexpress.com
Country
China
ProdList
774
Advantage
58
Zhengzhou First biochem technology Co.,Ltd.
Tel
0371-68865717 13213090566
Email
firstbio@126.com
Country
China
ProdList
15
Advantage
58
Xinxiang Yicheng Biotechnology Co.,LTD
Tel
0373-6014999 18937330588
Email
xxycswsale@163.com
Country
China
ProdList
69
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Hongene Biotech Corporation
Tel
021-64757213
Fax
86-21-64700613
Email
info@hongene.com
Country
China
ProdList
672
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
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View Lastest Price from 2'-Deoxy-2'-fluorocytidine manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
2'-Deoxy-2'-fluorocytidine 10212-20-1
Price
US $0.00/g
Min. Order
100g
Purity
≥98%
Supply Ability
20t
Release date
2023-05-11
Zhejiang Hengkang Pharmaceutical Co., Ltd.
Product
2'-FLUORO-D-CYTIDINE 10212-20-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500kg per month
Release date
2022-12-27
SHANGHAI NOVRIBO BIOTECH
Product
2'-F-2'-deoxyCytidine;2‘-F-dC 10212-20-1
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-21

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