2'-Deoxy-2'-fluorocytidine

ChemicalBook > CAS DataBase List > 2'-Deoxy-2'-fluorocytidine

2'-Deoxy-2'-fluorocytidine

Product Name: 2'-Deoxy-2'-fluorocytidine
CAS No.: 10212-20-1
Chemical Name: 2'-Deoxy-2'-fluorocytidine
Synonyms: 2'-FC;2'-FdC;RO-8013;2'-F-dC;2'-FANA-C;NSC 529432;2’-F-2’-dC;2'-Fluoro-d-Cytidine;2'-F-2'-deoxycytidine;2'-Deoxy-2"-fuorocytidine
CBNumber: CB8670324
Molecular Formula: C9H12FN3O4
Formula Weight: 245.21
MOL File: 10212-20-1.mol

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2'-Deoxy-2'-fluorocytidine Property

Melting point:: 167 °C
Boiling point:: 500.1±60.0 °C(Predicted)
Density: 1.82±0.1 g/cm3(Predicted)
refractive index: 80 ° (C=1, MeOH)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: Soluble in DMSO, Methanol.
pka: 12.84±0.70(Predicted)
form: Powder
color: White to Off-white
Water Solubility: Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C)
InChI: InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1
InChIKey: NVZFZMCNALTPBY-XVFCMESISA-N
SMILES: OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O
CAS DataBase Reference: 10212-20-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3614
Product name: 2'-Deoxy-2'-fluorocytidine Hydrate
Purity: >98.0%(T)
Packaging: 1g
Price: $68
Updated: 2024/03/01

Alfa Aesar

Product number: J65632
Product name: 2'-Fluoro-2'-deoxycytidine, 99%
Packaging: 1g
Price: $52.65
Updated: 2024/03/01

TRC

Product number: D232945
Product name: 2’-Deoxy-2’-fluoroCytidine
Packaging: 2g
Price: $145
Updated: 2021/12/16

TRC

Product number: D232945
Product name: 2’-Deoxy-2’-fluoroCytidine
Packaging: 10g
Price: $525
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 33485
Product name: 2?-Deoxy-2?-fluorocytidine
Purity: 98%purewithdatedHPLCUVchromatogram
Packaging: 1mg
Price: $685
Updated: 2021/12/16

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2'-Deoxy-2'-fluorocytidine Chemical Properties,Usage,Production

Description

2'-Deoxy-2'-fluorocytidine is a nucleoside analog. It has antiviral effects and can synergize with T705 to effectively inhibit Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2'-Deoxy-2'-fluorocytidine can also inhibit dihydrofolate reductase, thereby preventing the production of tetrahydrofolate, which is required for the synthesis of purines and pyrimidines. It has a certain inhibitory effect on poliovirus, herpes simplex virus, vesicular stomatitis virus and influenza A virus.

Chemical Properties

White Solid

Uses

2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s pread.

in vitro

2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.

References

[1] Stephen R. Welch. “Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus.” Antiviral research 147 (2017): Pages 91-99.

2'-Deoxy-2'-fluorocytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Deoxy-2'-fluorocytidine Suppliers

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View Lastest Price from 2'-Deoxy-2'-fluorocytidine manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.

Product: 2'-Deoxy-2'-fluorocytidine 10212-20-1
Price: US $0.00/g
Min. Order: 100g
Purity: ≥98%
Supply Ability: 20t
Release date: 2023-05-11

Zhejiang Hengkang Pharmaceutical Co., Ltd.

Product: 2'-FLUORO-D-CYTIDINE 10212-20-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg per month
Release date: 2022-12-27

SHANGHAI NOVRIBO BIOTECH

Product: 2'-F-2'-deoxyCytidine；2‘-F-dC 10212-20-1
Price: US $100.00/kg
Min. Order: 0.009999999776482582kg
Purity: 99%
Supply Ability: 5tons
Release date: 2023-03-21

10212-20-1, 2'-Deoxy-2'-fluorocytidineRelated Search:

Cytidine 4-amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine 5'-Deoxy-5-fluorocytidine Dmt-2'-f-dc(ac) amidite 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate Gemcitabine hydrochloride 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 2''-DEOXY-2''-FLUORO-5-IODOCYTIDINE 2'-FLUORO-5'-O-DIMETHOXYTRITYL-N4-ACETYL-D-CYTIDINE 2'-DEOXY-3',5'-DI-O-BENZOYL-2',2'-DIFLUOROCYTIDINE-13C,15N2 DTBS-GEMCITABINE gemcitabine 2'-DEOXY-2'-FLUOROCYTIDINE, [3H]- 2'-FLUORO-2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE LITHIUM SALT GEMCITABINE, [5-3H]- N4-Benzyl-2'-deoxy-2'-fluoro-5'-O-tritylcytidine-3'-O-cyanoethyldiisopropropylphosphoramidite

4-amino-1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

4-AMINO-1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1H-PYRIMIDIN-2-ONE

2'-FC

2'-FdC

1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)cytosine

1-(2-Fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine

RO-8013

2'-DEOXY-2'-FLUOROCYTIDINE(2'-FLUORO-2'- DEOXYCYTIDINE, 2'-FC)

2'-Deoxy-2'-fluoro-D-cytidine

2''-DEOXY-2''-FLUOROCYTIDINE,99+%

2'-Deoxy-2'-fluorocytidine Hydrate

2'-Deoxy-2'-fluorocytidine ,98%

2'-Fluoro-2'-deoxy-β-D-ribofuranosylcytosine

FN-009 2'-Fluoro-2'-deoxy-cytidine

Cytidine, 2'-deoxy-2'-fluoro-

2'-FANA-C

NSC 529432

2'-Deoxy-2'-fluorocytidine&nbsp

2'-Deoxy-2'-fluorocytidine≥ 99% (HPLC)

Fludarabine Phosphate Impurity 18

2'-Fluoro-2'-deoxycytidine, >98.0%(T)

2'-Deoxy-2'-fluorocytidineHydrate&gt

2’-F-2’-dC

4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one USP/EP/BP

4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl...

Crimean-Congo hemorrhagic fever,2' Deoxy 2' fluorocytidine,Inhibitor,nucleoside analog,inhibit,Influenza Virus,2'Deoxy2'fluorocytidine,Antiviral,CCHFV

2'-Fluoro-2'-Deoxycytidine (FdC)

4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

2'-Fluoro-2'-Deoxycytidine

2'-Deoxy-2"-fuorocytidine

2'-F-2'-deoxycytidine

2'-Deoxy-2'-fluorocytidine

2'-F-dC

2'-Fluoro-d-Cytidine

2''-Deoxy-2''-fluorocytidine

10212-20-1

110212-20-1

C9H12FN3O4xH2O

C9H12N3O4F

C9H12FN3O4

Biochemistry

Nucleosides and their analogs

Nucleosides, Nucleotides & Related Reagents

10212-20-1

Nucleosides

Modified（deoxy）nucleoside

Nucleosides-2'-F Nucleosides