Preparation
ChemicalBook > CAS DataBase List > 6-Chlorooxindole

6-Chlorooxindole

Preparation
Product Name
6-Chlorooxindole
CAS No.
56341-37-8
Chemical Name
6-Chlorooxindole
Synonyms
6-chloroindolin-2-one;6-CHLORO-2-OXINDOLE;6-Chloro-2-oxoindole;AKOS 207-09;6-CHLOROOXINDOLE;6-CHLORO0XINDOLE;Isatin Impurity 18;6-Chlorooxindole 98%;6-Chlorooxindole,98%;6-Chlorooxindole >
CBNumber
CB8681061
Molecular Formula
C8H6ClNO
Formula Weight
167.59
MOL File
56341-37-8.mol
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6-Chlorooxindole Property

Melting point:
195-199 °C (lit.)
Boiling point:
329.0±42.0 °C(Predicted)
Density 
1.362±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Dimethylformamide
form 
powder to crystal
pka
13.39±0.20(Predicted)
color 
Light yellow to Brown
InChI
InChI=1S/C8H6ClNO/c9-6-2-1-5-3-8(11)10-7(5)4-6/h1-2,4H,3H2,(H,10,11)
InChIKey
CENVPIZOTHULGJ-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC(Cl)=C2)CC1=O
CAS DataBase Reference
56341-37-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-43-36/37/38
Safety Statements 
37/39-36-26
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
636215
Product name
6-Chloro-2-oxindole
Purity
97%
Packaging
5g
Price
$23.9
Updated
2024/03/01
Sigma-Aldrich
Product number
636215
Product name
6-Chloro-2-oxindole
Purity
97%
Packaging
25g
Price
$42.7
Updated
2024/03/01
TCI Chemical
Product number
C2024
Product name
6-Chlorooxindole
Purity
>98.0%(GC)
Packaging
5g
Price
$32
Updated
2024/03/01
TCI Chemical
Product number
C2024
Product name
6-Chlorooxindole
Purity
>98.0%(GC)
Packaging
25g
Price
$95
Updated
2024/03/01
Alfa Aesar
Product number
A19674
Product name
6-Chlorooxindole, 98%
Packaging
5g
Price
$40.65
Updated
2024/03/01
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6-Chlorooxindole Chemical Properties,Usage,Production

Preparation

STEP A: 3-(2-nitro-4-chlorophenyl)pyruvic acid To a cooled mixture prepared by adding 13.6 g. of sodium to 300 ml. of ethanol is added a solution of 100 g. of 4-chloro-2-nitrotoluene and 84 g of diethyloxalate in 150 ml of ethanol while maintaining the temperature below 20℃. The resulting mixture is refluxed for one hour, cooled, 400 ml. of water added and the resulting mixture refluxed for 90 minutes. The ethanol is then evaporated to a small volume and the resulting precipi tate containstan and black material and the black mate rial is mechanically separated and discarded and the remainder (filtrate plus tan precipitate) used in the next step. STEP B: 4-chloro-2-nitro-phenylacetic acid The filtrate of Step A, above, is adjusted to pH 8-9 with 2 N sodium hydroxide and is heated at 35-40℃. while adding a 3-6% aqueous hydrogen peroxide solution until samples no longer turn dark on treatment with 2N sodium hydroxide. The tan precipitate is suspended in 1500 ml of water, adjusted to pH 8-9 and similarly treated with aqueous hydrogen peroxide. The combined reaction mixtures are then acidified with concentrated hydrochloride acid to obtain a precipitate which are re covered by filtration, washed 3 times with water and dried in vacuo. The crude product (mp 145-150° C) is recrystallized from ether to obtain 4-chloro-2-nitro phenylacetic acid, m.p. 156-159℃. STEP C: The product of Step B, above, is subjected to reductive cyclization analogously to Step B of Example 1 to obtain 6-chloro-oxindole, m.p. 185-189℃.

Chemical Properties

Off-white to tan crystalline powder

Uses

6-Chlorooxindole is a useful research chemical used in the design of potent non-peptide MDM2 inhibitors.

Definition

ChEBI: 6-Chlorooxindole is a member of indoles.

Application

6-chlorooxyindole, also known as 6-chloro-2-indolone, is an intermediate of Ziprasidone hydrochloride. Ziprasidone is an atypical broad-spectrum antipsychotic developed by Pfizer for the treatment of schizophrenia with a strong affinity for serotonin and dopamine receptor antagonists, particularly the 5-HTA2/DAD2 receptor.

6-Chlorooxindole Preparation Products And Raw materials

Raw materials

Potassium tert-butoxide N,N-Dimethylformamide Dimethyl malonate Acetic acid 2,5-Dichloronitrobenzene Iron Lithium chloride

Preparation Products

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6-Chlorooxindole Suppliers

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View Lastest Price from 6-Chlorooxindole manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
6-Chlorooxindole 56341-37-8
Price
US $999.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-22
Shanghai Yongzeng Technology Co.,Ltd
Product
6-Chlorooxindole 56341-37-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98%min
Supply Ability
1000kgs
Release date
2024-09-03
Shanghai Joiny Pharmaceutical Co.,LTD
Product
6-Chlorooxindole 56341-37-8
Price
US $0.00/kg
Min. Order
1kg
Purity
97%
Supply Ability
500kg
Release date
2022-12-13

56341-37-8, 6-ChlorooxindoleRelated Search:

Indometacin Oxindole Chlorine dioxide Chlortalidone 1-(2,6-Dichlorophenyl)indolin-2-one Trazodone Zirconyl chloride octahydrate 3'-Chloroacetophenone Indole-3-acetic acid Chlormezanone Dihydromyrcenol 6-Chloroindole KETAMINE/ZYLAZINE SOLUTION--SCHEDULE*III ITEM 4,6-DICHLORO-1H-INDOLE-2,3-DIONE Ziprasidone hydrochloride monohydrate 6-Chloroisatin Ziprasidone HCl Difluorochloromethane

  • 6-Chloro-2-oxoindole
  • 6-Chloro-1,3-dihydro-2H-indol-
  • 6-Chlorooxindole 98%
  • 6-Chloro-2-oxindole in stock Factory
  • 6-Chloro-2-oxindole / 6-Chloro-1,3-dihydro-indole 2-one
  • 6-Chloro-1,3-dihydroindole-2-one
  • 6-Chlorooxindole,98%
  • 6-Chloro-1,3-dihvdro-indol-2-one
  • 6-Chloro-2-oxindole 98%
  • 6-chloro indole ketone
  • 6-Chloroindolin-2-one, 6-Chloro-1,3-dihydro-2H-indol-2-one
  • 1H-indol-6-yl hypochlorite
  • 6-chloroindolin-2-one
  • 2H-Indol-2-one,6-chloro-1,3-dihydro-
  • 6-CHLOROINDOL-2(3H)-ONE
  • 6-CHLOROOXINDOLE
  • 6-CHLORO-2-OXOINDOLINE
  • 6-CHLORO-2-OXINDOLE
  • 6-CHLORO-2-INDOLINONE
  • 6-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE
  • 6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
  • AKOS 207-09
  • LABOTEST-BB LT01147821
  • 6-Chloroindole-2(3H)-one
  • 6-Chlorooxindole &gt
  • 6-Chloro-1,3,-dihydro-indol-2-on
  • 6-Chlorooxindole 56341-37-8
  • Ziprasidone Impurity 19
  • Isatin Impurity 18
  • 6-Chloroindole-2-one
  • 6 -chloro oxi indole
  • 6-CHLORO0XINDOLE
  • 56341-37-8
  • 563411-37-8
  • C8H6ClNO
  • C8H86ClNO
  • C8H6NOCI
  • Halogenated Heterocycles
  • Indoles
  • Heterocyclic Building Blocks
  • Building Blocks
  • Indoles and derivatives
  • Indole
  • Indoles
  • Heterocycles
  • Indole and Indoline
  • Starting Raw Materials & Intermediates
  • blocks
  • IndolesOxindoles
  • Indole/indoline/oxindole