4-Chloropyridine-3-carboxaldehyde
- Product Name
- 4-Chloropyridine-3-carboxaldehyde
- CAS No.
- 114077-82-6
- Chemical Name
- 4-Chloropyridine-3-carboxaldehyde
- Synonyms
- 4-Chloronicotinaldehyde;4-CHLORO-3-FORMYLPYRIDINE;4-chloro-3-pyridylazaldehyde;4-chloropyridin-3-carbaldehyde;4-chloropyridine-3-carbaldehyde;4-chloro-3-pyridinecarbaldehyde;4-chloro-3-pyridincarboxaldehyde;4-Chloro-3-pyridinecarboxaldehyde;4-CHLOROPYRIDINE-3-CARBOXALDEHYDE;4-Chhloropyridine-3-carboxaldehyde
- CBNumber
- CB8687487
- Molecular Formula
- C6H4ClNO
- Formula Weight
- 141.56
- MOL File
- 114077-82-6.mol
4-Chloropyridine-3-carboxaldehyde Property
- Boiling point:
- 228.8±20.0 °C(Predicted)
- Density
- 1.332±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 1.89±0.10(Predicted)
- form
- solid
- color
- Pale yellow
- InChI
- InChI=1S/C6H4ClNO/c7-6-1-2-8-3-5(6)4-9/h1-4H
- InChIKey
- DYRMBQRXOMOMNW-UHFFFAOYSA-N
- SMILES
- C1=NC=CC(Cl)=C1C=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C381278
- Product name
- 4-Chloropyridine-3-carboxaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C381278
- Product name
- 4-Chloropyridine-3-carboxaldehyde
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- C381278
- Product name
- 4-Chloropyridine-3-carboxaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 070118
- Product name
- 4-Chloropyridine-3-carboxaldehyde
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- FC55551
- Product name
- 4-Chloropyridine-3-carboxaldehyde
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
4-Chloropyridine-3-carboxaldehyde Chemical Properties,Usage,Production
Chemical Properties
White to light yellow powder
Synthesis
626-61-9
68-12-2
114077-82-6
General procedure: a tetrahydrofuran solution (50 ml) of 4-chloropyridine (25.0 g, 0.22 mol) was slowly added dropwise to a solution of diisopropylammonium lithium prepared from a hexane solution of 1.6 M n-butyllithium (179 ml, 0.29 mol) with diisopropylamine (33.4 g, 0.33 mol) in tetrahydrofuran (300 ml) under the protection of argon gas, keeping the reaction temperature at -78°C. After dropwise addition, stirring was continued for 30 min. Subsequently, N,N-dimethylformamide (DMF, 19.3 g, 0.26 mol) was added and the reaction mixture was gradually warmed up to room temperature. After completion of the reaction, extraction was carried out with ethyl acetate (200 ml) and 5% aqueous ammonium chloride solution (300 ml). The organic layer was separated, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent to give the crude product 4-chloro-3-pyridinecarboxaldehyde (27 g, 86% yield) as an oil. The product was characterized by 1H-NMR (200 MHz, CDCl3): δ 7.45 (1H, d, J = 5.0 Hz), 8.69 (1H, d, J = 5.0 Hz), 9.05 (1H, s), 10.51 (1H, s).
References
[1] Patent: EP1348706, 2003, A1. Location in patent: Page/Page column 37
[2] Patent: US2011/53975, 2011, A1. Location in patent: Page/Page column 60
[3] Journal of the American Chemical Society, 2013, vol. 135, # 40, p. 14916 - 14919
[4] Patent: WO2018/152329, 2018, A1. Location in patent: Page/Page column 44
[5] Patent: WO2004/41806, 2004, A2. Location in patent: Page 88-89
4-Chloropyridine-3-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloropyridine-3-carboxaldehyde manufacturers
- Product
- 4-Chloropyridine-3-carboxaldehyde 114077-82-6
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-10
- Product
- 4-Chloropyridine-3-carboxaldehyde 114077-82-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03
- Product
- 4-Chloropyridine-3-carboxaldehyde 114077-82-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-14