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4-Chloropyridine-3-carboxaldehyde

Product Name
4-Chloropyridine-3-carboxaldehyde
CAS No.
114077-82-6
Chemical Name
4-Chloropyridine-3-carboxaldehyde
Synonyms
4-Chloronicotinaldehyde;4-CHLORO-3-FORMYLPYRIDINE;4-chloro-3-pyridylazaldehyde;4-chloropyridin-3-carbaldehyde;4-chloropyridine-3-carbaldehyde;4-chloro-3-pyridinecarbaldehyde;4-chloro-3-pyridincarboxaldehyde;4-Chloro-3-pyridinecarboxaldehyde;4-CHLOROPYRIDINE-3-CARBOXALDEHYDE;4-Chhloropyridine-3-carboxaldehyde
CBNumber
CB8687487
Molecular Formula
C6H4ClNO
Formula Weight
141.56
MOL File
114077-82-6.mol
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4-Chloropyridine-3-carboxaldehyde Property

Boiling point:
228.8±20.0 °C(Predicted)
Density 
1.332±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
1.89±0.10(Predicted)
form 
solid
color 
Pale yellow
InChI
InChI=1S/C6H4ClNO/c7-6-1-2-8-3-5(6)4-9/h1-4H
InChIKey
DYRMBQRXOMOMNW-UHFFFAOYSA-N
SMILES
C1=NC=CC(Cl)=C1C=O
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36-43
Safety Statements 
26-36/37
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C381278
Product name
4-Chloropyridine-3-carboxaldehyde
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
C381278
Product name
4-Chloropyridine-3-carboxaldehyde
Packaging
500mg
Price
$90
Updated
2021/12/16
TRC
Product number
C381278
Product name
4-Chloropyridine-3-carboxaldehyde
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
070118
Product name
4-Chloropyridine-3-carboxaldehyde
Packaging
1g
Price
$49
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC55551
Product name
4-Chloropyridine-3-carboxaldehyde
Packaging
500mg
Price
$60
Updated
2021/12/16
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4-Chloropyridine-3-carboxaldehyde Chemical Properties,Usage,Production

Chemical Properties

White to light yellow powder

Synthesis

626-61-9

68-12-2

114077-82-6

General procedure: a tetrahydrofuran solution (50 ml) of 4-chloropyridine (25.0 g, 0.22 mol) was slowly added dropwise to a solution of diisopropylammonium lithium prepared from a hexane solution of 1.6 M n-butyllithium (179 ml, 0.29 mol) with diisopropylamine (33.4 g, 0.33 mol) in tetrahydrofuran (300 ml) under the protection of argon gas, keeping the reaction temperature at -78°C. After dropwise addition, stirring was continued for 30 min. Subsequently, N,N-dimethylformamide (DMF, 19.3 g, 0.26 mol) was added and the reaction mixture was gradually warmed up to room temperature. After completion of the reaction, extraction was carried out with ethyl acetate (200 ml) and 5% aqueous ammonium chloride solution (300 ml). The organic layer was separated, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent to give the crude product 4-chloro-3-pyridinecarboxaldehyde (27 g, 86% yield) as an oil. The product was characterized by 1H-NMR (200 MHz, CDCl3): δ 7.45 (1H, d, J = 5.0 Hz), 8.69 (1H, d, J = 5.0 Hz), 9.05 (1H, s), 10.51 (1H, s).

References

[1] Patent: EP1348706, 2003, A1. Location in patent: Page/Page column 37
[2] Patent: US2011/53975, 2011, A1. Location in patent: Page/Page column 60
[3] Journal of the American Chemical Society, 2013, vol. 135, # 40, p. 14916 - 14919
[4] Patent: WO2018/152329, 2018, A1. Location in patent: Page/Page column 44
[5] Patent: WO2004/41806, 2004, A2. Location in patent: Page 88-89

4-Chloropyridine-3-carboxaldehyde Preparation Products And Raw materials

Raw materials

Nitrogen Ethyl formate Sodium sulfate Sodium Diisopropylamine Tetrahydrofuran Ethyl acetate Methanol 4-Chloropyridinium chloride n-Butyllithium

Preparation Products

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4-Chloropyridine-3-carboxaldehyde Suppliers

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View Lastest Price from 4-Chloropyridine-3-carboxaldehyde manufacturers

PNP Biotech Co. Ltd
Product
4-Chloropyridine-3-carboxaldehyde 114077-82-6
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2023-07-10
Dideu Industries Group Limited
Product
4-Chloropyridine-3-carboxaldehyde 114077-82-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-03
Career Henan Chemical Co
Product
4-Chloropyridine-3-carboxaldehyde 114077-82-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-14

114077-82-6, 4-Chloropyridine-3-carboxaldehydeRelated Search:

Chlorosulfonyl isocyanate Pentachloropyridine MCPA SODIUM N-Chlorosuccinimide 2-Chloro-5-chloromethylpyridine 3-Aminopyridine Clopidol 2-Chloro-3-cyanopyridine 3-Hydroxypyridine 4-Chloropyridinium chloride 4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID 4-Chloronicotinic acid ETHYL 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE 4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBONYL CHLORIDE 5-CHLORO-2-FORMYLPYRIDINE 5-Chloropyridine-3-carboxaldehyde 3-CHLOROPYRIDINE-4-CARBOXALDEHYDE 2-CHLOROPYRIDINE-3-CARBOXALDEHYDE,2-Chloropyridine-3-carboxaldehyde, 2-Chloro-3-formylpyridine

  • 4-CHLOROPYRIDINE-3-CARBOXALDEHYDE
  • 4-CHLORO-3-FORMYLPYRIDINE
  • 3-Pyridinecarboxaldehyde,4-chloro-(9CI)
  • 4-chloro-3-pyridincarboxaldehyde
  • 4-Chloronicotinaldehyde
  • 4-Chloro-3-pyridinecarboxaldehyde
  • 4-chloropyridin-3-carbaldehyde
  • 4-Chloro-pyridine-3-carbaldehyde/4- Chloronicotinaldehyde
  • 4-chloro-3-pyridinecarbaldehyde
  • 4-chloropyridine-3-carbaldehyde
  • 3-Pyridinecarboxaldehyde, 4-chloro-
  • 4-Chloropyridine-3-carboxaldehyde≥ 98.5% (HPLC)
  • 4-Chloropyridine-3-carboxaldehyde, 4-Chloro-3-formylpyridine
  • 4-Chhloropyridine-3-carboxaldehyde
  • 4-chloro-3-pyridylazaldehyde
  • 4-Chloropyridine-3-carboxaldehyde ISO 9001：2015 REACH
  • 4-Chloropyridine-3-carboxaldehyde CAS NO.114077-82-6
  • 114077-82-6
  • Pyridines
  • pyridine series
  • PYRIDINE
  • Building Blocks
  • Heterocycle-Pyridine series