ChemicalBook > CAS DataBase List > Lactose

Lactose

Product Name
Lactose
CAS No.
63-42-3
Chemical Name
Lactose
Synonyms
D-LACTOSE;MILK SUGAR;BETA-LACTOSE;LACTIN;Lactosum;LACTOBIOSE;D-Lactose Anhydrous;Lactosum , anhydrous;Lactose (anhydrous) CRS;4-O-BETA-GALACTOPYRANOSYL-D-GLUCOSE
CBNumber
CB8710411
Molecular Formula
C12H22O11
Formula Weight
342.3
MOL File
63-42-3.mol
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Lactose Property

Melting point:
222.8°C
Boiling point:
397.76°C (rough estimate)
Density 
1.5300
refractive index 
1.5376 (estimate)
storage temp. 
2-8°C
solubility 
Freely but slowly soluble in water, practically insoluble in ethanol (96 per cent).
form 
Powder
pka
12.39±0.20(Predicted)
color 
White to Off-white
Odor
Mildly sweet taste.
optical activity
Alpha form +85.0 → +52.6 Beta form +34.9 → +55.4
Water Solubility 
5-10 g/100 mL at 20 ºC
BRN 
93796
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
-3.391 (est)
CAS DataBase Reference
63-42-3(CAS DataBase Reference)
NIST Chemistry Reference
D-Glucose, 4-o-«beta»-D-galactopyranosyl-(63-42-3)
EPA Substance Registry System
Lactose (63-42-3)
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Safety

Safety Statements 
24/25
WGK Germany 
2
RTECS 
OD9625000
TSCA 
Yes
HS Code 
17021100
Hazardous Substances Data
63-42-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
17814
Product name
Lactose
Purity
tested according to Ph.Eur.
Packaging
1kg
Price
$206
Updated
2024/03/01
Sigma-Aldrich
Product number
1356676
Product name
Anhydrous lactose
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$519
Updated
2024/03/01
Alfa Aesar
Product number
J66376
Product name
D-Lactose
Packaging
500g
Price
$80.4
Updated
2023/06/20
Alfa Aesar
Product number
J66376
Product name
D-Lactose
Packaging
1kg
Price
$141
Updated
2023/06/20
Sigma-Aldrich
Product number
PHR1025
Product name
Lactose, Anhydrous
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$86.2
Updated
2024/03/01
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Lactose Chemical Properties,Usage,Production

Chemical Properties

white crystals or powder

Chemical Properties

Anhydrous lactose occurs as white to off-white crystalline particles or powder. Several different brands of anhydrous lactose are commercially available which contain anhydrous b-lactose and anhydrous a-lactose. Anhydrous lactose typically contains 70–80% anhydrous b-lactose and 20–30% anhydrous a-lactose.

Uses

A disaccharide sugar present in milk.

Uses

Lactose is a disaccharide carbohydrate that occurs in mammalian milk except that of the whale and the hippopotamus. it is princi- pally obtained as a cows’ milk derivative. it is also termed milk sugar and it is a reducing sugar consisting of glucose and galactose. its most common commercial form is alpha-monohydrate, with the beta-anhydride form available to a lesser extent. all forms in solution will equilibrate to a beta:alpha ratio of 62.25:37.75 at 0°c. it is about one-sixth as sweet as sugar and is less soluble. it functions as a flow agent, humectant, crystallization control agent, and sweetener. it is used in baked goods for flavor, browning, and tenderizing and in dry mixes as an anticaking agent.

Uses

D-Lactose is used for the culture of lactic acid metabolizing bacteria, lactic acid bacteria. D-Lactose is used to identify and characterized galectins.

Definition

A sugar found in milk. It is a disaccharide composed of glucose and galactose units.

Production Methods

There are two anhydrous forms of lactose: a-lactose and b-lactose. The temperature of crystallization influences the ratio of a- and blactose. The anhydrous forms that are commercially available may exhibit hygroscopicity at high relative humidities. Anhydrous lactose is produced by roller drying a solution of lactose above 93.5°C. The resulting product is then milled and sieved. Two anhydrous a-lactoses can be prepared using special drying techniques: one is unstable and hygroscopic; the other exhibits good compaction properties. However, these materials are not commercially available.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Air & Water Reactions

Water soluble.

Reactivity Profile

Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

ACUTE/CHRONIC HAZARDS: Lactose should be considered toxic.

Pharmaceutical Applications

Anhydrous lactose is widely used in direct compression tableting applications, and as a tablet and capsule filler and binder. Anhydrous lactose can be used with moisture-sensitive drugs due to its low moisture content. It may also be used in intravenous injections.

Safety

Lactose is widely used in pharmaceutical formulations as a diluent and filler-binder in oral capsule and tablet formulations. It may also be used in intravenous injections. Adverse reactions to lactose are largely due to lactose intolerance, which occurs in individuals with a deficiency of the intestinal enzyme lactase, and is associated with oral ingestion of amounts well over those found in solid dosage forms.

storage

Mold growth may occur under humid conditions (80% RH and above). Lactose may develop a brown coloration on storage, the reaction being accelerated by warm, damp conditions. At 80°C and 80% RH, tablets containing anhydrous lactose have been shown to expand 1.2 times after one day.
Lactose anhydrous should be stored in a well-closed container in a cool, dry place.

Purification Methods

-Lactose crystallises from water below 93.5o as the hydrate which can be dried at 80o/14mm. [Horst Recl Trav Chim, Pays-Bas 72 878 1953, Beilst 17 III/IV 3066.]

Incompatibilities

Lactose anhydrous is incompatible with strong oxidizers. When mixtures containing a hydrophobic leukotriene antagonist and anhydrous lactose or lactose monohydrate were stored for six weeks at 40°C and 75% RH, the mixture containing anhydrous lactose showed greater moisture uptake and drug degradation.
Studies have also shown that in blends of roxifiban acetate (DMP-754) and lactose anhydrous, the presence of lactose anhydrous accelerated the hydrolysis of the ester and amidine groups.
Lactose anhydrous is a reducing sugar with the potential to interact with primary and secondary amines (Maillard reaction) when stored under conditions of high humidity for extended periods.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (IM, IV: powder for injection solution; IV and sublingual preparations; oral: capsules and tablets; powder for inhalation; vaginal). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Lactose Preparation Products And Raw materials

Raw materials

MILK Α-protein Whey

Preparation Products

Whev’redliced lactose Abamectin Lactulose Pepsin L-carnitine LACTITOL Whey CARAMEL Whey saIts thyroid powder
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Lactose Suppliers

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View Lastest Price from Lactose manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Lactose 63-42-3
Price
US $999.00-666.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-14
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Lactose 63-42-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-08
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Lactose 63-42-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-09

63-42-3, LactoseRelated Search:

D-Glucose monohydrate Glucose oxidase CORN SYRUP D-Lactose monohy 2'-O-METHYLLACTOSE 4-O-BETA-GALACTOPYRANOSYL-D-MANNOPYRANOSE BETA-D-LACTOSE LACTOSE, MONOHYDRATE Lactobionic acid CALCIUM GLUBIONATE 2,3,4,6-Tetra-O-acetyl-alpha-D-galactopyranosyl bromide 3,4,6-Tri-O-acetyl-D-galactal 2,3,4,6-TETRA-O-BENZYL-D-GALACTOPYRANOSE D(+)-Galactosamine hydrochloride 2-Deoxy-D-galactose 1,2:3,4-Di-O-isopropylidene-D-galactopyranose D(+)-Glucose CLARITHROMYCIN LACTOBIONATE Milk Sugar

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