4-HYDROXY-3-NITROPHENYLACETIC ACID
- Product Name
- 4-HYDROXY-3-NITROPHENYLACETIC ACID
- CAS No.
- 10463-20-4
- Chemical Name
- 4-HYDROXY-3-NITROPHENYLACETIC ACID
- Synonyms
- TIMTEC-BB SBB007785;3-NITRO-4-HYDROXYPHENYLACETIC ACID;4-HYDROXY-3-NITROPHENYLACETIC ACID;4-Hydroxy-3-nitrobenzeneacetic acid;4-Hydroxy-3-nitrophenylaceticAcid>Benzeneacetic acid, 4-hydroxy-3-nitro-;2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID;4-Hydroxy-3-nitrophenylacetic acid,99%;4-Hydroxy-3-nitrophenylacetic acid 98%;4-Hydroxy-3-nitrophenylacetic acid, 10 mM in DMSO
- CBNumber
- CB8737517
- Molecular Formula
- C8H7NO5
- Formula Weight
- 197.14
- MOL File
- 10463-20-4.mol
4-HYDROXY-3-NITROPHENYLACETIC ACID Property
- Melting point:
- 146-148 °C (lit.)
- Boiling point:
- 334.23°C (rough estimate)
- Density
- 1.5023 (rough estimate)
- refractive index
- 1.5700 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- ethanol: soluble5%, clear, yellow to orange
- form
- crystalline
- pka
- 4.25±0.10(Predicted)
- color
- yellow
- BRN
- 2696044
- CAS DataBase Reference
- 10463-20-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 219924
- Product name
- 4-Hydroxy-3-nitrophenylacetic acid
- Purity
- 99%
- Packaging
- 1g
- Price
- $50.25
- Updated
- 2025/07/31
- Product number
- H1362
- Product name
- 4-Hydroxy-3-nitrophenylacetic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- H1362
- Product name
- 4-Hydroxy-3-nitrophenylacetic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $151
- Updated
- 2025/07/31
- Product number
- H948685
- Product name
- 4-Hydroxy-3-nitrophenylacetic Acid
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 279309
- Product name
- 4-Hydroxy-3-nitrophenylacetic acid
- Packaging
- 50mg
- Price
- $425
- Updated
- 2021/12/16
4-HYDROXY-3-NITROPHENYLACETIC ACID Chemical Properties,Usage,Production
Chemical Properties
yellow crystalline powder
Uses
4-Hydroxy-3-nitrophenylacetic acid was used in the synthesis of 4-hydroxy-3-nitrophenylacetyl caproic acid.
Uses
A metabolite of Nitrotyrosine (N597000), which is excreted in the urine.
Definition
ChEBI: (4-hydroxy-3-nitrophenyl)acetic acid is a monocarboxylic acid that is acetic acid carrying a 2-hydroxy-3-nitrophenyl substituent at C-2. It has a role as a hapten. It is a conjugate acid of a (4-hydroxy-3-nitrophenyl)acetate.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 30, p. 1166, 1987 DOI: 10.1021/jm00390a009
General Description
4-Hydroxy-3-nitrophenylacetic acid enhances the ice-nucleation activity of Xanthomonas campestris.
Synthesis
156-38-7
10463-20-4
General procedure for the synthesis of 4-hydroxy-3-nitrophenylacetic acid from p-hydroxyphenylacetic acid: (a) Nitration reaction: fuming nitric acid (1.36 mL) was slowly added dropwise to a solution of 4-hydroxyphenylacetic acid (4.00 g, 26.3 mmol) in acetic acid (25 mL) under cooling in an ice bath. After the dropwise addition was completed, the reaction mixture was slowly warmed up to room temperature and reacted for 1 hour, during which time the solution gradually changed from yellow to brown color, accompanied by the formation of a precipitate. After completion of the reaction, the solid product was collected by filtration and recrystallized from ethyl acetate/hexane mixed solvent to obtain yellow needle-like crystals of 4-hydroxy-3-nitrophenylacetic acid (3.61 g, 70% yield). The structure of the product was confirmed by 1H-NMR: δ (CDCl3-d4/DMSO, 4:1) 3.50 (2H, s), 7.04 (1H, d, J = 9 Hz), 7.46 (1H, dd, J = 9, 3 Hz), 7.94 (1H, d, J = 3 Hz).
References
[1] Synthetic Communications, 1985, vol. 15, # 12, p. 1075 - 1080
[2] Patent: US5229510, 1993, A
[3] Journal of Medicinal Chemistry, 1987, vol. 30, # 7, p. 1166 - 1176
[4] Patent: US9995679, 2018, B2. Location in patent: Page/Page column 52
[5] Patent: US5852191, 1998, A
4-HYDROXY-3-NITROPHENYLACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4-HYDROXY-3-NITROPHENYLACETIC ACID Suppliers
- Tel
- --
- Fax
- --
- david.davies@lehvoss.co.uk
- Country
- United Kingdom
- ProdList
- 892
- Advantage
- 58
- Tel
- --
- Fax
- --
- ales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 2598
- Advantage
- 58
- Tel
- --
- Fax
- --
- cms.marketing@cms-chemicals.com
- Country
- United Kingdom
- ProdList
- 3708
- Advantage
- 60
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
- Tel
- --
- Fax
- --
- info@apinchemicals.com
- Country
- United Kingdom
- ProdList
- 6184
- Advantage
- 60
- Tel
- --
- Fax
- --
- enquiries@keyorganics.ltd.uk
- Country
- United Kingdom
- ProdList
- 6663
- Advantage
- 50
- Tel
- --
- Fax
- --
- info@atlantic-chemicals.com
- Country
- United Kingdom
- ProdList
- 5618
- Advantage
- 63
- Tel
- --
- Fax
- --
- kevinbanks@molekula.com
- Country
- United Kingdom
- ProdList
- 6140
- Advantage
- 66
- Tel
- --
- Fax
- --
- sales@carbonesci.com
- Country
- United Kingdom
- ProdList
- 6666
- Advantage
- 30
- Tel
- --
- Fax
- --
- sales@gs-chem.com
- Country
- United Kingdom
- ProdList
- 6098
- Advantage
- 47
- Tel
- --
- Fax
- --
- vernam@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6375
- Advantage
- 65
- Tel
- --
- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
- Tel
- --
- Fax
- --
- info@apinchemicals.com
- Country
- United Kingdom
- ProdList
- 6807
- Advantage
- 42
- Tel
- --
- Fax
- --
- solutions@vwr.com
- Country
- United Kingdom
- ProdList
- 6548
- Advantage
- 82
- Tel
- --
- Fax
- --
- sales@bio-farma.com
- Country
- United Kingdom
- ProdList
- 4236
- Advantage
- 55
View Lastest Price from 4-HYDROXY-3-NITROPHENYLACETIC ACID manufacturers
- Product
- 2-(4-hydroxy-3-nitrophenyl)acetic acid 10463-20-4
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2025-05-12
- Product
- 4-HYDROXY-3-NITROPHENYLACETIC ACID 10463-20-4
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- 4-Hydroxy-3-nitrophenylacetic acid 10463-20-4
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2020-01-10