ChemicalBook > CAS DataBase List > Picroside II

Picroside II

Uses

Product Name: Picroside II
CAS No.: 39012-20-9
Chemical Name: Picroside II
Synonyms: AMPHICOSIDE;PICROSID II;Picroside-2;Picroside Ⅱ;PICROSIDE II;PICROSIDE ò;Picroside a…;Berberine II;AMPHICOSIDE II;Picroside II-RM
CBNumber: CB8745879
Molecular Formula: C23H28O13
Formula Weight: 512.46
MOL File: 39012-20-9.mol

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Picroside II Property

Melting point:: 145 - 155oC
Boiling point:: 780.8±60.0 °C(Predicted)
Density: 1.66±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: ethanol: soluble1mg/mL, clear, colorless
pka: 8.07±0.20(Predicted)
form: Solid
color: Pale Yellow
InChIKey: AKNILCMFRRDTEY-MRFBWRKESA-N
SMILES: C12(CO)OC1C(C1C=COC(O[C@H]3[C@H](O)[C@H]([C@H](O)[C@@H](CO)O3)O)C21)OC(=O)C1=CC=C(O)C(OC)=C1 |&1:12,13,15,16,18,r|

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G0174
Product name: Picroside II
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $362
Updated: 2023/06/20

Sigma-Aldrich

Product number: G0174
Product name: Picroside II
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $1170
Updated: 2023/06/20

TCI Chemical

Product number: P2594
Product name: Picroside II
Packaging: 100MG
Price: $345
Updated: 2025/07/31

Cayman Chemical

Product number: 30319
Product name: Picroside II
Packaging: 10mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 30319
Product name: Picroside II
Packaging: 250mg
Price: $717
Updated: 2024/03/01

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Picroside II Chemical Properties,Usage,Production

Uses

Picroside II similar to Picroside I (P437635), acts as an oxygen free radical scavenger and thus promotes anti-inflammatory activity and may be used in the treatment of arthritis or ischemic injury.

Chemical Properties

Yellow needle-shaped crystals, soluble in methanol, derived from Picrorhizoma Coptidis.

Uses

Picroside II similar to Picroside I (P437635), acts as an oxygen free radical scavenger and thus promotes anti-inflammatory activity and may be used in the treatment of arthritis or ischemic injury.

Definition

ChEBI: Picroside ii is a tannin.

Biological Activity

Picroside II displaysmany anti-cancer properties such as anti-metastatic, anti-angiogenic, and anti-apoptotic activities in both in vitro and in vivo studies.It also exerts antioxidant, anti-inflammatory, and antidiarrheal effectsagainst acute oxidative injuries such as severe acute pancreatitis-inducedintestinal barrier injury. PII has protective effects onischemia/reperfusion (I/R)-induced injury by interacting with differentmechanisms in various in vitro and in vivo models.', 'Phytochemical found in Traditional Chinese Medicine herbal preparations. Picroside II, a glucoside, is reported to have hepatoprotective, cardioprotective, and neuroprotective properties.

in vivo

Picroside II (0-20 mg/kg, i.g., given in two doses) protects liver cells from damage and prevents apoptosis^[1].
Picroside II (20 mg/kg, intravenous injection, given in four doses) inhibits the activation of NLRP3 inflammasome and NF-κB pathway in mice, reducing the inflammatory response in sepsis and enhancing immune function^[3].
Picroside II (20 mg/kg, intraperitoneal injection, a single dose) protects the blood-brain barrier by inhibiting oxidative signaling pathways in a rat model of ischemia-reperfusion injury^[4].
Picroside II (5-20 mg/kg, i.g., once a day for seven days) has anti-lipid peroxidation effects and protects against mitochondrial damage in mice with liver injury^[5].

Animal Model:	DGalN and LPS(HY-D1056)-induced acute liver injury in mice^[1]
Dosage:	0, 5, 10, 20 mg/kg; administered 10 min before and 4 h after D-GalN and LPS administration
Administration:	i.g.
Result:	Reduced the levels of alanine aminotransferase and aspartate aminotransferase in the serum, decreased MDA content, had a dose-dependent effect on hepatocyte apoptosis, and upregulated the expression of the bcl-2 gene.

Animal Model:	Sepsis mouse model^[3]
Dosage:	20 mg/kg; four times injected (2 h, 14 h, 26 h and 38 h after CLP)
Administration:	Intravenous injection (i.v.)
Result:	Improved survival, reduced sepsis-related infiltration and attenuated lung injury, enhanced bacterial clearance, reduced IL-6, IL-1β, and TNF-α levels, inhibited splenic lymphocyte apoptosis, reduced p-NF-κB (p65) expression, and reduced IL-1β and caspase-1 levels.

Animal Model:	Rats with cerebral ischemia-reperfusion injury^[4]
Dosage:	20 mg/kg; single dose
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced the nervous system score, neuronal injury, BBB damage, ROS content and NADPH oxidase activity, down-regulated the protein levels of Rac-1, Nox2, ROCK, MLCK and MMP-2, and up-regulated the expression of claudin-5.

Animal Model:	Mouse model of liver injury induced by CCl4, D-GalN and AP^[5]
Dosage:	5, 10, 20mg/kg; daily; 7 days
Administration:	i.g.
Result:	Reduced the high levels of ALT and AST in serum caused by CCl4, D-GalN and AP, significantly alleviated liver cell damage, reduced MDA, and increased SOD and GSH-Px content in a dose-dependent manner, inhibited AP-induced liver toxicity in mice, enhanced ATPase activity, and improved mitochondrial swelling.

Picroside II Preparation Products And Raw materials

Raw materials

Preparation Products

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Picroside II Suppliers

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View Lastest Price from Picroside II manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Picroside II 39012-20-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-20

Career Henan Chemical Co

Product: Picroside II 39012-20-9
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

39012-20-9, Picroside IIRelated Search:

Catalpol PICROSIDE I Vanillic acid Propylparaben Ethyl 3,4-dihydroxybenzoate 2-Methyl-2,3-epoxy-1-propanol 4-HYDROXYBENZOIC ACID ISOAMYL ESTER HEPTYL-BETA-D-GLUCOPYRANOSIDE Cyclopentene oxide 1,2-EPOXY-3-METHYLBUTANE Butylparaben 2-Benzyloxyethanol (2-ISOPROPOXYETHYL) ACETATE 1-Methylcyclopentanol ISOBUTYL BENZOATE 1,1,3-TRIMETHOXYBUTANE 1,3-cyclopentanediol Aucubin

6'-VANILLOYL CATALPOL

AMPHICOSIDE

PICROSIDE II

PICROSID II

beta-d-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, [1aS-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha)]-

AMPHICOSIDE II

PICROSIDE ò

(1aS-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha))-1a,1b,2,5a,6,6a-Hexahydro-6-((4-hydroxy-3-methoxybenzoyl)oxy)-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl-beta-D-glucopyranoside

Vanilloyl catalpol

[(1aS)-1a,1bα,2,5aα,6,6aβ-Hexahydro-6α-[(4-hydroxy-3-methoxybenzoyl)oxy]-1aβ-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside

6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl,[1aS-(1aα,1bβ,2β,5aβ,6β,6aα)]-

Picroside-2

(1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-β-D-glucopyranoside

Picroside II, 98%, from Picrorhiza scrophulariiflora Pennell.

Picroside a…

Berberine II

Picroside II, ≥98% (HPLC)

β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl

Picroside II USP/EP/BP

(1aS,1bS,2S,5aR,6S,6aS)-1a-(Hydroxymethyl)-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-6-yl 4-hydroxy-3-methoxybenzoate

Picrorhizae Kurroa Root Extract

Picroside II-RM

Picroside Ⅱ

39012-20-9

C23H28O13

Inhibitors

Miscellaneous Natural Products

Iridoids

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract