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L-Leucinamide hydrochloride

Product Name
L-Leucinamide hydrochloride
CAS No.
10466-61-2
Chemical Name
L-Leucinamide hydrochloride
Synonyms
H-Leu-NH2Cl;LEU-NH2 HCL;H-LEU-NH2 HCL;L-Leu-NH2.HCl;LEUCINE-NH2 HCL;H-L-LEU-NH2 HCL;L-Leucinamide HCl;L-LEUCINEAMIDE HCL;H-Leu-NH2·HCl ,≥99%;L-Leucinamide hydroc
CBNumber
CB8754976
Molecular Formula
C6H15ClN2O
Formula Weight
166.65
MOL File
10466-61-2.mol
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L-Leucinamide hydrochloride Property

Melting point:
254256°C
alpha 
9 º (c=1, H2O)
refractive index 
9.8 ° (C=5, H2O)
storage temp. 
Inert atmosphere,Room Temperature
Water Solubility 
very faint turbidity in Water
form 
Powder
color 
White to off-white
optical activity
[α]25/D +10°, c = 5 in H2O
Sensitive 
Hygroscopic
BRN 
4237021
CAS DataBase Reference
10466-61-2(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29241900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
286427
Product name
L-Leucinamide hydrochloride
Purity
99%
Packaging
5g
Price
$128
Updated
2025/07/31
TCI Chemical
Product number
L0094
Product name
L-Leucinamide Hydrochloride
Purity
>98.0%(T)
Packaging
1g
Price
$28
Updated
2025/07/31
TCI Chemical
Product number
L0094
Product name
L-Leucinamide Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$89
Updated
2025/07/31
Usbiological
Product number
281409
Product name
L-Leucine amide hydrochloride
Packaging
10g
Price
$353
Updated
2021/12/16
Usbiological
Product number
164678
Product name
L-Leucinamide Hydrochloride
Packaging
1g
Price
$403
Updated
2021/12/16
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L-Leucinamide hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

L-Leucinamide Hydrochloride, is a derivative of Leucine, which is an essential amino acid, and acts as a nutrient signal to stimulate protein synthesis. L-Leucinamide Hydrochloride, is shown to be the potential elicitors of insulin secretion in rats.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

7517-19-3

10466-61-2

The general procedure for the synthesis of L-leucinamide hydrochloride from L-leucine methyl ester hydrochloride is as follows: the synthesis is an improvement on a previously published method. The raw material L-leucine methyl ester hydrochloride can be purchased from Alfa Aesar. L-Leucine methyl ester hydrochloride (1.0 g, 5.5 mmol) and methanol (10 mL) were added to a glass pressure tube, followed by a methanol solution of 7N ammonia (7.9 mL, 55 mmol). The reaction tube was sealed, heated to 50 °C and kept for 2 days. After completion of the reaction, the mixture was concentrated in vacuum. The crude product was suspended in 1,4-dioxane (10 mL) and converted to hydrochloride by addition of 1,4-dioxane solution (1.7 mL, 6.8 mmol) in 4N HCl. Mixing was facilitated by sonication. The solvent and excess HCl were removed using a rotary evaporator, 1,4-dioxane (10 mL) was added during the process to help remove excess HCl.The product was purified by recrystallization from hot isopropanol, allowing crystals to form slowly at room temperature. The recrystallized solid was placed under high vacuum to remove residual solvent. The final yield was 0.55 g (60%). The product had a melting point of 216-218 °C, a specific spin [α]D24 of +12.0° (c 0.50, methanol), and an HPLC purity (200 nm) greater than 99% and significantly lower than 0.5% of the parent leucine.1H NMR ((CD3)2SO) δ 8.29 (broad single peak, 3H), 7.96 (single peak, 1H), 7.48 (single peak, 1H), and 3.66 (multiple peaks, 1H), 1.67 (multiple peaks, 1H), 1.56 (multiple peaks, 2H), 0.92 (double peaks, J=3Hz, 3H), 0.90 (double peaks, J=3Hz, 3H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 20, p. 5000 - 5006
[2] Journal fur Praktische Chemie - Chemiker - Zeitung, 1996, vol. 338, # 3, p. 251 - 256

L-Leucinamide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Leucinamide hydrochloride Suppliers

Americas 1 Belgium 1 China 144 Europe 3 France 1 Germany 8 India 9 Japan 7 South Korea 1 Spain 1 Switzerland 6 United Kingdom 7 United States 42 Global 231
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View Lastest Price from L-Leucinamide hydrochloride manufacturers

Career Henan Chemical Co
Product
L-Leucinamide hydrochloride 10466-61-2
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-07-27

10466-61-2, L-Leucinamide hydrochlorideRelated Search:

Glycine ALTRENOGEST Transglutaminase Glycinamide hydrochloride Boc-D-Glutamine L-Glutamine Topotecan hydrochloride 6-Aminocaproic acid L-Alanyl-L-Glutamine L-Leucyl-L-Leucine methyl ester (hydrochloride) H-LEU-PHE-OH H-L-Hgn(Trt)-OH H-LEU-LYS (Z) - OH L-Leucine tert-butyl ester hydrochloride L-LEUCYL-L-ALANINE Ethyl L-leucinate hydrochloride Tris(hydroxymethyl)aminomethane H-LEU-LEU-OH

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